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Tag: Cancer: Cervical

The Federation of Gynecology and Obstetrics 2018 staging schema improves discriminatory ability for women with stage IB cervical tumors

FIGO 2018 Staging Ups Discrimination of Stage 1B Cervical Cancer

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Classifying all women with positive lymph nodes into single stage yields highly variable survival rates
Surgery at high-volume centers is associated with decreased local recurrence risk and improved survival for women with early-stage cervical cancer

Higher Surgical Volume May Improve Outcomes in Cervical Cancer

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Findings show radical hysterectomy at high-volume centers tied to better survival in early cervical cancer
A cervical cancer screening strategy that involves cytologic testing every three years from ages 21 to 29 years and then continuing cytologic testing or switching to low-cost high-risk human papillomavirus testing every five years is reasonable

Some Cervical Cancer Screening Strategies More Cost-Effective

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Most lifetime QALYs seen with cytologic testing every three years, repeated for ASC-US
Many populations have increasing or stabilized incidence trends in cervical adenocarcinoma

Cervical Adenocarcinoma Rates Increased in Some Populations

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Increasing and stabilizing incidence trends seen for several subpopulations; declines attenuated in SCC
The number of cervical precancers in the United States declined from 2008 to 2016

CDC: Recent Decline Seen in High-Grade Cervical Lesions

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Vast majority of cervical precancer cases attributable to HPV types targeted by 9-valent HPV vaccine
For women with cervical intraepithelial neoplasia grade 2 or 3 associated with high-risk human papillomavirus

Histologic Clearance of CIN2/3 Seen With HPV Therapeutic Vaccine

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In phase II trial, rate of complete resolution of CIN2/3 significantly higher for vaccine versus placebo group
Routine vaccination of young girls aged 12 to 13 years with human papillomavirus vaccine results in a reduction in preinvasive cervical disease

Drop Seen in Preinvasive Cervical Disease With HPV Vaccination

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Vaccine effectiveness increased for immunization at younger age
The current standard of care for advanced cervical cancer -- external beam radiation therapy and chemotherapy in combination with brachytherapy -- provides significantly higher overall survival over chemoradiation alone; however

Brachytherapy Boost Ups Survival in Locally Advanced Cervical Cancer

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Findings observed regardless of treatment duration; disparities for brachytherapy use seen in vulnerable populations
The proportion of human papillomavirus 16/18-positive cervical intraepithelial neoplasia grades 2 to 3 or adenocarcinoma in situ declined from 2008 to 2014

Decline Observed in HPV Type 16/18 Cervical Precancers in U.S.

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Greatest declines seen among vaccinated women; decreases also seen in unvaccinated women
In the absence of further intervention

44.4 Million Estimated to Be Diagnosed With Cervical Cancer by 2069

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From 2020 to 2069, 6.7 to 7.7 million cases could be averted by scaling up HPV vaccination by 2020