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Tag: Cancer: Cervical

A clinical diagnosis of stress-related disorders or an occurrence of stressful life events around the time of cervical cancer diagnosis is associated with an increased risk for cancer-specific mortality

Psychologic Distress Linked to Cervical Cancer Mortality

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Risk up with diagnosis of stress-related disorders or an occurrence of stressful life events around diagnosis
One dose of prophylactic human papillomavirus vaccine may be as effective as two or three doses in preventing high-grade disease in a high-coverage setting

One Dose of HPV Vaccine May Be Sufficient in Certain Situations

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One dose compared with two or three doses in preventing cervical precancer in high-coverage settings
The Federation of Gynecology and Obstetrics 2018 staging schema improves discriminatory ability for women with stage IB cervical tumors

FIGO 2018 Staging Ups Discrimination of Stage 1B Cervical Cancer

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Classifying all women with positive lymph nodes into single stage yields highly variable survival rates
Surgery at high-volume centers is associated with decreased local recurrence risk and improved survival for women with early-stage cervical cancer

Higher Surgical Volume May Improve Outcomes in Cervical Cancer

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Findings show radical hysterectomy at high-volume centers tied to better survival in early cervical cancer
A cervical cancer screening strategy that involves cytologic testing every three years from ages 21 to 29 years and then continuing cytologic testing or switching to low-cost high-risk human papillomavirus testing every five years is reasonable

Some Cervical Cancer Screening Strategies More Cost-Effective

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Most lifetime QALYs seen with cytologic testing every three years, repeated for ASC-US
Many populations have increasing or stabilized incidence trends in cervical adenocarcinoma

Cervical Adenocarcinoma Rates Increased in Some Populations

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Increasing and stabilizing incidence trends seen for several subpopulations; declines attenuated in SCC
The number of cervical precancers in the United States declined from 2008 to 2016

CDC: Recent Decline Seen in High-Grade Cervical Lesions

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Vast majority of cervical precancer cases attributable to HPV types targeted by 9-valent HPV vaccine
For women with cervical intraepithelial neoplasia grade 2 or 3 associated with high-risk human papillomavirus

Histologic Clearance of CIN2/3 Seen With HPV Therapeutic Vaccine

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In phase II trial, rate of complete resolution of CIN2/3 significantly higher for vaccine versus placebo group
Routine vaccination of young girls aged 12 to 13 years with human papillomavirus vaccine results in a reduction in preinvasive cervical disease

Drop Seen in Preinvasive Cervical Disease With HPV Vaccination

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Vaccine effectiveness increased for immunization at younger age
The current standard of care for advanced cervical cancer -- external beam radiation therapy and chemotherapy in combination with brachytherapy -- provides significantly higher overall survival over chemoradiation alone; however

Brachytherapy Boost Ups Survival in Locally Advanced Cervical Cancer

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Findings observed regardless of treatment duration; disparities for brachytherapy use seen in vulnerable populations