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Tag: Cancer: Cervical

Continuing regular cytology screening up to age 75 years or performing an exit human papillomavirus (HPV) test to confirm the absence of oncogenic HPV strains past the age of 55 years offers preventive benefit for older women with a cervix

Age to Stop Cervical Cancer Screening Depends on Test Used

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Negative HPV test, HPV-cytology co-test tied to low remaining lifetime cancer risk for unvaccinated
For patients with early-stage cervical cancer

Minimally Invasive Sx May Up Mortality in Early Cervical Cancer

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Two studies show increased mortality and reduced disease-free, overall survival versus open surgery
Women with high-risk human papillomavirus (hrHPV)-positive cervical tumors have a substantially better prognosis than women with hrHPV-negative tumors

Positive HPV Status Tied to Better Cervical Cancer Prognosis

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Five-year relative survival ratio better for hrHPV-positive cases than for hrHPV-negative cases
Catch-up doses of quadrivalent human papillomavirus vaccination are effective for girls and women aged 14 to 20 years at the time of first dose

Catch-Up HPV Doses Effective to Age 21 Against Cervical Neoplasia

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But catch-up doses not effective against CIN for women who initiated vaccination at 21 to 26 years
The U.S. Preventive Services Task Force has updated the recommendations for screening for cervical cancer; the final recommendation statement has been published in the Aug. 21 issue of the Journal of the American Medical Association.

USPSTF Updates Guidance for Cervical Cancer Screening

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Cytology recommended every three years from age 21; different screening options from age 30 to 65
The use of primary human papillomavirus testing versus cytology results in reduced likelihood of cervical intraepithelial neoplasia grade 3 or worse at 48 months

HPV Cervical CA Screening Cuts Odds of Later CIN3+ Diagnosis

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Use of primary HPV testing results in significantly lower odds of CIN3+ compared with cytology testing
Human papillomavirus vaccines protect against cervical precancer in adolescent girls and young women

Good Evidence That HPV Vaccines Protect Against Cervical Precancer

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High-certainty evidence for protection in adolescent girls and young women aged 15 to 26 years
Diethylstilbestrol-related clear-cell adenocarcinoma of the vagina and cervix is associated with increased risk of death

Mortality Risk Persists for Cancer Tied to Prenatal DES Exposure

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Women with DES-related clear-cell adenocarcinoma had 27-fold higher mortality at 10 to 34 years
A considerable proportion of women are diagnosed with cervical cancer after age 65

Cervical Cancer Frequently Diagnosed After Age 65

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Almost 20 percent of cervical cancer cases are diagnosed in women older than 65
Most untreated cervical intraepithelial neoplasia grade 2 lesions regress

Many Untreated CIN2 Lesions Regress Spontaneously

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Regression of cervical intraepithelial neoplasia grade 2 lesions especially likely in younger women