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Tag: Cancer: Breast

Multigene testing for hereditary breast and/or ovarian cancer identifies more mutations that are likely to change clinical management

Multigene Test IDs More at Risk for Hereditary Breast/Ovarian CA

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Testing for mutations other than BRCA1/2 in HBOC may change clinical management for women, families
Diastolic dysfunction frequently develops after anthracycline chemotherapy for breast cancer

Diastolic Dysfunction Common After Anthracycline Chemo

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BMI and age independently linked to diastolic dysfunction after anthracycline chemotherapy
For women with breast cancer

Hypofractionated Breast Irradiation = Reduced Toxicity

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Two studies show benefits for hypofractionated vs conventionally fractionated whole-breast irradiation
Single-stage implant breast reconstruction is a less invasive procedure that may offer good aesthetic outcome with no additional oncologic risk in selected patients

No Increased Risk for One-and-Done Breast Reconstruction

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Single-stage implant procedures after mastectomy may be a good option for selected patients
Some performance indicators for mammography test sets are associated with aspects of clinical audit parameters

Test Set Performance Indicators Correlate Well With Clinical Audit

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In mammography, JAFROC and location sensitivity correlate with several clinical audit parameters
There's more evidence that two classes of generic drugs (aromatase inhibitors and bisphosphonates) reduce the risk of death in postmenopausal women with early breast cancer

Generic Meds Boost Survival in Some Early Breast Cancers

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Researchers found benefit from aromatase inhibitors and bisphosphonates
Some women who have surgery for early-stage breast cancer may benefit from additional radiation to nearby lymph nodes

Nodal Radiation Doesn’t Impact Early Breast Cancer Survival

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Researchers find it lowers chances of recurrence, but does not boost overall survival
Biomarkers can be used to guide decisions on systemic therapy for women with metastatic breast cancer

ASCO Guidelines: Biomarker Use in Metastatic Breast CA Treatment

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Hormone receptor status of metastases should be used to guide tx if supported by clinical scenario
Among women with a family history of breast cancer

Breast CA Survivors Gain More Weight Than Cancer-Free Peers

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Survivors, especially those who received chemo, gained more weight versus cancer-free women
Increased numbers of small cancers and precancerous lesions are found in geographical areas where more mammograms take place; however

Regular Mammograms May Lead to Widespread Overdiagnosis

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No significant difference in breast cancer deaths for counties with higher screening, detection rates