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Tag: Cancer: Breast

Physicians who report a social network member with a poor breast cancer prognosis are more likely to recommend routine breast cancer screening for younger and older age groups

Doctors’ Personal Experience of Breast Cancer May Impact Care

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Physicians with social network member with poor prognosis more likely to recommend screening
Ogivri (trastuzumab-dkst) has been approved by the U.S. Food and Drug Administration as the nation's first biosimilar drug to treat certain breast and stomach cancers

FDA Approves Biosimilar Ogivri for Breast, Stomach Cancers

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Ogivri is approved to treat HER2+ breast and gastric or gastroesophageal junction adenocarcinoma cancers
Urban American Indians and Alaskan Natives with cancer have a significantly higher comorbidity burden

Mortality Up for Some Cancers in Urban-Dwelling Native Americans

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Urban American Indians and Alaskan Natives with cancer have significantly higher comorbidity burden
Body mass index is associated with detection of large breast tumors (>2 cm) among screen-detected and interval cancers

RSNA: BMI Linked to Detection of Larger Breast Tumors

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BMI linked to detection of tumor larger than 2 cm among screen-detected and interval cancers
Non-alcoholic fatty liver disease is associated with development of cancer

NAFLD Linked to Increased Cancer Incidence Rate

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NAFLD strongly tied to development of hepatocellular carcinoma, CRC in males, breast cancer in females
African-American women with type 2 diabetes appear to be at increased risk of developing estrogen receptor-negative (ER-) breast cancer

ER- Breast CA Risk Up for African-Americans With T2DM

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ER- type accounts for increased breast cancer risk in African-American women; highest risk in nonobese
When adjuvant endocrine therapy for estrogen receptor-positive breast cancer is stopped after five years

Breast Cancer Recurrences Steady After Therapy Cessation

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Women with ER-positive BC who stop therapy after 5 years have steady recurrence rate up to 20 years
After adoption of the Affordable Care Act

Incidence of Early-Stage Breast CA, CRC Up With ACA Adoption

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No change in incidence of locally advanced or metastatic-stage cancer after ACA adoption
PARP inhibitors demonstrate activity in triple-negative breast cancer tumors without BRCA1/2 mutations

PARP Inhibitors Promising Beyond BRCA1/2 Altered Tumors

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Talazoparib caused regression in 5 patient-derived xenografts, 4 without germline BRCA1/2 mutations
The combination of elastography and color Doppler ultrasonography with B-mode US in women with dense breasts can increase the positive predictive value of screening and reduce the number of false-positives

Elastography and Color Doppler Improve Breast Ultrasound

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Together, the technologies increase predictive value of screening while decreasing unnecessary biopsies