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Tag: Cancer: Breast

The addition of abemaciclib to fulvestrant provides a statistically significant and clinically meaningful gain in median overall survival

Drug Combo Extends Survival in Advanced Breast Cancer

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Benefit seen for addition of CDK4/6 inhibitor after progression of disease on endocrine therapy
The breast cancer death rate is continuing to decline

Breast Cancer Mortality Rate Continues to Decline in the U.S.

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Pace of decline slowed from 1.9 percent during 1998 to 2011 to 1.3 percent during 2011 to 2017
Male breast cancer patients have higher mortality after cancer diagnosis than female patients

Higher Mortality Seen for Male Breast Cancer Patients

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Clinical characteristics, undertreatment correlated with 63.3 percent excess mortality rate for men
Screening for breast cancer in men has increased over time

Screening for Breast Cancer in Men Has Increased Over Time

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Risk higher for older age, Ashkenazi descent, genetic mutations, and personal, first-degree family hx
Maintaining full doses of chemotherapy

Full Chemo Doses May Improve Survival in Breast Cancer

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Maintaining full doses of chemo especially important early in the treatment course
For older women

Mammos May Not Benefit Elderly Women With Chronic Illness

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Risk for death from other causes much higher than risk for breast cancer death with increasing comorbidity, age
The U.S. Preventive Services Task Force recommends that clinicians offer risk-reducing medications to women at increased breast cancer risk. These recommendations form the basis of a final recommendation statement published in the Sept. 3 issue of the Journal of the American Medical Association.

USPSTF Advises Meds to Reduce Risk for Primary Breast Cancer

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Offer risk-reducing meds to women at higher risk for breast cancer, low risk for adverse medication effects
Use of menopausal hormone therapy is associated with an increased incidence of breast cancer

Type and Timing of Menopausal HRT Affect Risk for Breast Cancer

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Some excess risk persists for >10 years after ceasing therapy; magnitude varies with duration of use
Men should be included in clinical trials of new breast cancer treatments

FDA: Men Should Be Included in Breast Cancer Clinical Trials

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Draft guidance that men be included in breast cancer trials issued by the FDA on Aug. 26
The U.S. Preventive Services Task Force recommends that women who are at increased risk for BRCA1/2 mutations should undergo genetic counseling

USPSTF Recommends Genetic Counseling for High BRCA Risk

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But counseling not recommended for women without personal, family history, ancestry associated with BRCA mutations