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Tag: Cancer: Brain

Sex differences have been identified in response to therapy among glioblastoma patients

Sex Differences ID’d in Response to Glioblastoma Treatment

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Standard therapy more effective for female versus male patients with glioblastoma
A liquid biopsy using blood or cerebrospinal fluid can effectively quantify changes in mutation levels among pediatric patients being treated for diffuse midline gliomas

Liquid Biopsy Can Assess Tx Response of Peds Brain Tumors

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Study is the first to document the utility of liquid biopsy in a pediatric brain tumor population
The presence of visible fluorescence can serve as an intraoperative diagnostic surgical biomarker of high-grade glioma within a brain tumor

Fluorescence Can ID High-Grade Glioma During Sx for Brain Tumor

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Visible fluorescence shows presence of high-grade glioma cells within tumor mass during surgery
Checkpoint blockade immunotherapy is associated with significant increases in overall survival in a real-world population of patients undergoing treatment for melanoma brain metastases

Novel Immunotherapy May Up Survival in Melanoma Brain Mets

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Findings in patients receiving checkpoint blockade immunotherapy for melanoma brain metastases
For patients with melanoma and untreated brain metastases

Nivolumab + Ipilimumab Shows Efficacy for Untreated Brain Mets

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Findings from open-label, phase 2 study in patients with melanoma and untreated brain metastases
Intratumoral infusion of recombinant nonpathogenic polio-rhinovirus chimera can be delivered safely and is tied to higher survival rates than those of historical controls

Polio-Rhinovirus Promising for Malignant Glioma Patients

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Intratumoral infusion appears to be safe, improve survival in those with grade IV malignant glioma
For patients with glioblastoma

TTFields Tied to Improved Survival in Glioblastoma Patients

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No negative influence on health-related quality of life apart from more itchy skin, which was expected
There are noticeable differences in hospice utilization among patients with malignant glioma

Variation Seen in Hospice Use for Malignant Glioma

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Differences by race, sex, age, level of education, urban versus rural residence identified
In patients with progressive glioblastoma

Drug Combo Doesn’t Lengthen Glioblastoma Survival

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Lomustine+bevacizumab may increase progression-free, but not overall, survival versus lomustine alone
Overall survival for patients with melanoma brain metastases has improved significantly since 2000

Overall Survival Up for Melanoma Brain Metastases

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Median overall survival from time of diagnosis has increased from 7.5 to 22.7 months