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Disrupted sleep is associated with increased amyloid-β production in adults

Disrupted Sleep Linked to Increased Amyloid-β Production

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Sleep deprivation tied to increased overnight amyloid-β-38, -40, -42 levels by 25 to 30 percent
Parkinson's disease patients with depression have impaired white matter integrity

Impaired White Matter Integrity for Depression in Parkinson’s

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Reduced fractional anisotropy values in left anterior corona radiata, left cingulum of depressed patients
For patients with unruptured intracranial aneurysms that are 3 mm or smaller

No Treatment or Imaging Follow-Up Most Effective for Tiny UIAs

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Highest health benefit for unruptured intracranial aneurysms with no treatment or preventive follow-up
Nonalcoholic fatty liver disease is associated with smaller total cerebral brain volume

NAFLD Linked to Smaller Total Cerebral Brain Volume

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Significant correlation even after adjustment for all covariates, including age, sex, alcohol consumption
HIV-positive individuals treated with combination antiretroviral therapy have poorer neuropsychological test scores than controls but no significant neuropsychological decline over time

Poorer Neuropsychological Test Scores for HIV-Positive

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No significant neuropsychological decline during two-year period with combination antiretroviral therapy
Among older adults

Cardiac Index Linked to Cerebral Blood Flow Regardless of CVD

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No link for cardiac index with CBF in regions other than temporal lobes, cerebrovascular reactivity
Concentrations of cerebrospinal fluid β42-amyloid 42 derived from new immunoassays may show improved agreement with visual flutemetamol F18-labeled positron emission tomography assessment

Benefits for New Immunoassays for Measuring Aβ42 in CSF

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May show improved correlation with mass spectrometry reference measurement procedure
For patients with chronic valvular heart disease

Brain Measures Tied to Atrial Pressure in Valvular Heart Dz

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Linear link between white matter hyperintensity volume, RA pressure in chronic valvular heart disease
Systemic inflammation in midlife is associated with future neurodegeneration and cognitive aging

Midlife Systemic Inflammation Tied to Late-Life Brain Volume

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Smaller hippocampal, Alzheimer's signature region volumes seen 24 years after inflammation noted
Black men have increased prevalence and frequency of multiple intracranial atherosclerotic plaques

Race a Factor in Intracranial Atherosclerotic Disease

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Prevalence and frequency of multiple plaques were higher for black men