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Imetelstat

Imetelstat Deemed Active in Myelofibrosis, Thrombocythemia

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Responses for patients with myelofibrosis, essential thrombocythemia
An experimental blood test may one day detect the return of early-stage breast cancer months before it is revealed by computed tomography or magnetic resonance imaging

Blood Test Predicts Relapse in Early-Stage Breast Cancer

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Circulating tumor DNA analysis spots stray cells months before scans detect recurrence
Daratumumab monotherapy has a favorable safety profile and encouraging efficacy in patients with heavily pretreated and refractory myeloma in a phase 1-2 trial. The results of the study were published online Aug. 26 in the New England Journal of Medicine.

Daratumumab Monotherapy Promising for Multiple Myeloma

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Findings in a phase 1-2 study of patients with relapsed myeloma or relapsed/refractory myeloma
U.S. Food and Drug Administration approval of the drug Promacta (eltrombopag) has been expanded to include children 1 year and older with chronic immune thrombocytopenic purpura.

Promacta Approval Expanded for Children With Chronic ITP

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Builds on recent approval for ages 6 years and up for chronic immune thrombocytopenic purpura
The International Staging System combined with chromosomal abnormalities detected by interphase fluorescent in situ hybridization after CD138 plasma cell purification and serum lactate dehydrogenase has prognostic value in newly-diagnosed multiple myeloma

Revised Staging System Prognostic for Multiple Myeloma

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ISS plus chromosomal abnormalities, lactate dehydrogenase prognostic in multiple myeloma
The 2006 American Society of Clinical Oncology guidelines on use of hematopoietic colony-stimulating factors have been updated

ASCO Updates Guidelines for Colony-Stimulating Factor Use

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Special article updates 2006 guidelines, including addition of tbo-filgrastim and filgrastim-sndz
Extreme exercise may trigger sepsis in people who haven't trained properly

Extreme Exercising Without Training May Trigger Sepsis

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Exercise over a prolonged period of time allows endotoxins in the gut to leak into the bloodstream
An antibody fragment

Idarucizumab Deemed Effective for Dabigatran Reversal

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Findings among patients with serious bleeding or who require an urgent procedure
The drug elotuzumab reduces the risk of cancer progression and mortality by 30 percent when combined with the standard two-drug therapy for multiple myeloma

ASCO: Elotuzumab Shows Benefit in Multiple Myeloma

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Survival gains when elotuzumab was added to treatment
Articles relating to malignant hematology

High-Value Research of 2014 Presented for Hematology

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Author summarizes 2014 studies that are highly relevant to hematology