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Patients with thalassemia treated with hematopoietic stem cell transplantation have 30-year survival that is similar to that of conventionally treated patients

Good Survival for HSCT-Treated Thalassemia Patients

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Survival similar among those receiving hematopoietic stem cell transplant, conventional therapy
Addition of previously unconsidered genes from the Pediatric Sepsis Biomarker Risk Model can improve mortality risk stratification for children with septic shock

PERSEVERE-XP Improves Mortality Risk Stratification in Sepsis

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Addition of network of 18 mortality risk assessment genes related to TP53 improves PERSEVERE
Moderate and severe obstructive sleep apnea are associated with elevated blood coagulability markers

Moderate, Severe OSA Linked to Elevated Blood Coagulability

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Increases in prothrombin time in seconds and as international normalized ratio for OSA vs controls
A typical emergency department sees few cases of sepsis among adolescents

Emergency Departments See Few Cases of Sepsis in Adolescents

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Every 100 years, each of 12 emergency departments would treat 2.8 fatal sepsis cases
There is an increased risk of cardiovascular disease following hospital admission for sepsis or pneumonia that persists for at least five years after the infection

Higher Risk of CVD Persists After Hospital Stay for Severe Infection

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Risk persists for at least five years after sepsis, pneumonia with hospitalization
In a report published in the July 28 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report

Outbreak of Septic Arthritis Described in New Jersey

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Forty-one cases of septic arthritis linked to intra-articular injections administered at same practice
Amyloid beta (Aβ)38 has faster turnover kinetics than Aβ40 and Aβ42

AAIC: Turnover Kinetics Vary for Different Amyloid β Isoforms

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Half-life of Aβ isoforms about three hours; Aβ38 has faster turnover kinetics than Aβ40, Aβ42
For antiphospholipid antibody carriers

Low Platelet Count Linked to Thrombosis in aPL Carriers

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Among patients with low a-PL-S, those with low platelet count developed thrombosis more often
For patients with essential thrombocythemia

Review Questions Antithrombotic Tx in Essential Thrombocythemia

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Findings inconsistent, imprecise for benefits/risks of antiplatelet tx; no extractable data on anticoagulants
The presence of clonal hematopoiesis of indeterminate potential is associated with coronary heart disease

Clonal Hematopoiesis Linked to Coronary Heart Disease

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CHIP linked to coronary heart disease, myocardial infarction in humans; atherosclerosis in mice