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American Society of Hematology, Dec. 9-12

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The 59th American Society of Hematology Annual Meeting and Exposition The annual meeting of the American Society of Hematology was held from Dec....
A new approach to gene therapy can restore immune cell types in infants with newly diagnosed X-linked severe combined immunodeficiency

ASH: New Approach to Gene Tx Restores Immune Cells in X-SCID

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Efficient vector marking in bone marrow CD34+ cells, myeloid cells, B cells in newly diagnosed SCID
Plasma N-terminal pro-B-type natriuretic peptide levels are significantly lower for black than white individuals

NTproBNP Levels Are Significantly Lower in Blacks

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Higher NTproBNP levels linked to increased risk of death; this association did not differ by race
Hemlibra (emicizumab-kxwh) has been approved by the U.S. Food and Drug Administration to prevent or reduce the frequency of bleeding episodes among hemophilia A patients with Factor VIII inhibitors.

FDA OKs Drug for Hemophilia A With Factor VIII Inhibitors

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Weekly prophylactic treatment associated with substantial decrease in bleeding episodes
For patients with acute severe bleeding

Delay in Tranexamic Acid Administration Reduces Benefit

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Survival benefit decreases by 10 percent for every 15-minute delay in treatment for severe bleeding
Lenalidomide produces hematologic responses in myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis

Response to Lenalidomide Often Suboptimal in MDS/MPN-RS-T

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Hematological responses seen in three patients with MDS/MPN-RS-T, but the responses not durable
For males

Mortality Up for Male Recipients of Blood From Ever-Pregnant

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Receipt of red blood cell transfusion from ever-pregnant donor tied to increased risk for males
There is no evidence to support excluding patients with hereditary hemochromatosis from serving as blood donors

Hereditary Hemochromatosis Patients Can Safely Donate Blood

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No data to suggest that nonvoluntary nature of donations compromises safety of blood products
Although rare

Diabetes Insipidus Can Occur After Stopping Vasopressin

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Incidence may be underestimated due to a paucity of published reports, authors say
Sepsis is present in 6 percent of adult hospitalizations

EHR Data May Beat Claims Data in Assessing Sepsis Incidence

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Based on clinical data, no change seen in incidence of sepsis, combined outcome of death or discharge