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Using the true number of central lines as the denominator improves methods of determining central line-associated bloodstream infection rates

Method to Calculate Central Line Infections Flawed

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Counting multiple concurrent central lines may help account for hospitals with patients with higher acuity of care
About two-thirds of patients who survive hospitalization for sepsis have persistent elevation of inflammation and immunosuppression biomarkers

Persistent Inflammation After Sepsis Linked to Higher Mortality

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Persistent inflammation, immunosuppression linked to increased mortality and readmission after discharge
Blood transfusions received postpartum are associated with an increased risk for transfusion reactions

Transfusion Reactions Up With Postpartum Blood Transfusion

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Preeclampsia the single most important risk factor for transfusion reactions in this patient population
Individuals with low- or intermediate-risk monoclonal gammopathy of undetermined significance can experience progression to multiple myeloma within five years

MGUS Can Progress to Multiple Myeloma Within Five Years

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Risk factors associated with progression include IgA isotype, 15 g/L or more monoclonal spike
Breaches of recommended infection prevention practices have been identified in an outbreak of septic arthritis cases after intra-articular injections performed in a private outpatient facility

Safety Practice Violations ID’d in Septic Arthritis Outbreak

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Multiple breaches included inadequate hygiene, unsafe injection practices, poor cleaning, disinfection
State-mandated protocolized sepsis care is associated with a greater decrease in sepsis mortality compared with that seen in states not implementing sepsis regulations

Protocolized Sepsis Care Lowers Sepsis Mortality in NY State

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Compared with control states, decrease in sepsis mortality greater after implementation of regulations
There is no increased risk for mortality among patients receiving red blood cell transfusions from female

Mortality Not Higher With Transfusions From Female Donors

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Findings seen for red blood cells from female, previously pregnant, or sex-discordant donors
Transfusion dose density is an independent prognostic factor for progression-free survival in patients with myelodysplastic syndromes treated with red blood cell transfusions

Transfusion Dose Density Affects Myelodysplastic Syndrome Survival

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Negative effect of transfusion treatment on PFS occurs at density less than 3 units/16 weeks
For high-risk patients undergoing cardiac surgery with cardiopulmonary bypass

Restricting Blood Transfusions OK in Cardiac Surgery

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Restrictive approach does not increase risk for acute kidney injury in high-risk patients
Data from a blood donor screening program could represent a novel strategy for identifying familial hypercholesterolemia

Blood Donor Screening Data IDs Familial Hypercholesterolemia

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Highest estimated prevalence of FH seen in young versus older donors, and in men versus women