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Home Tags Birth Defects: Misc.

Tag: Birth Defects: Misc.

Projected increases in maternal heat exposure may result in increased congenital heart defect burden

Rising Temps May Up Burden of Congenital Heart Disease in U.S.

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Large increases in specific congenital heart defect subtypes projected in different regions
Over time

CDC: Slight Hike in Prevalence of Gastroschisis Since 2006-2010

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Prevalence higher in areas with high and medium versus low opioid prescription rates
Maternal use of β-blockers in the first trimester of pregnancy is not associated with a large increase in the risk for overall or cardiac congenital malformations

β-Blockers in 1st Trimester Do Not Up Congenital Malformations

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No large increase in the risk for overall, cardiac malformations in international cohort
For live-born infants with hypoplastic left heart syndrome and d-transposition of the great arteries

Poor Outcomes for Hispanic Infants With Congenital Heart Dz

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Socioeconomic factors account for significant portion of association between race/ethnicity, poor outcome
Use of ondansetron for the treatment of nausea and vomiting in pregnancy does not appear to be associated with birth defects

Ondansetron in Pregnancy Not Linked to Most Birth Defects

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Use for nausea, vomiting of pregnancy tied to modest increase in cleft palate, renal agenesis-dysgenesis
Updated guidelines have been developed for management of adult congenital heart disease

Guidelines Updated for Adult Congenital Heart Disease

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New classification system intended to capture complexity of anatomy and physiology of ACHD
Neonates with congenital heart disease have enlarged kidneys on average

Enlarged Kidneys in Neonates With Congenital Heart Disease

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Kidneys of neonates with left heart obstruction consistently found to be larger than normal
The absence of CHD4 in heart cells results in inappropriate production of non-cardiac muscle proteins

Lack of CHD4 Leads to Abnormal Myofibrils, Heart Defects

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Mutation results in failed repression of non-cardiac muscle protein production in developing heart cells
Many children of mothers with evidence of confirmed or possible Zika virus infection during pregnancy do not undergo all recommended evaluations

Neurodevelopmental Anomalies, Birth Defects Linked to Zika ID’d

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Many children born to mothers with Zika infection don't undergo all recommended assessments
Alcohol consumption early in pregnancy may be a risk factor for development of gastroschisis in neonates

Early Alcohol Use in Pregnancy Tied to Gastroschisis

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No association seen with illicit, prescription, or over-the-counter drug use