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Tag: Birth Defects: Misc.

Odds of Anxiety, Depression, ADHD Up With Congenital Heart Disease

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Youth with CHD have increased odds of anxiety and/or depression, ADHD, regardless of CHD severity

Birth Defects Tied to Rise in Lifelong Cancer Risk

Cancer Risk Up Into Adulthood for Those With Birth Defects

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Risk for cancer increased for individuals with nonchromosomal birth defects, chromosomal birth anomalies

Most patients with congenital heart disease are not at risk for severe COVID-19 infection

Risk for Severe COVID-19 Low With Congenital Heart Disease

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Higher risk for severe disease seen with genetic syndrome, adults at advanced physiological stage
As they get older

Poorer Exercise Capacity Persists With Ventricular Septal Defects

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Difference between patients with surgically repaired, unrepaired VSDs versus controls increased with age
Modafinil use during early pregnancy is not associated with significantly increased risk for major malformations in exposed infants

Modafinil in Early Pregnancy Not Tied to Congenital Malformations

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Large birth registry study conducted in Norway and Sweden did not show link to major malformations
In 2020 European Society of Cardiology guidelines

ESC Updates Guidelines for Adult Congenital Heart Disease

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Patients with congenital heart disease increasingly present as older adults, including the elderly
Changes have been suggested for the newborn critical congenital heart disease screening algorithm

Changes Proposed for Newborn Congenital Heart Disease Screen

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Oxygen saturation of at least 95 percent in both upper, lower extremities required to pass
For eight cancer types

Tumors of Embryonic Origin More Common in Children With Birth Defects

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Most common childhood cancer, acute lymphoblastic leukemia, seen at lower frequency in children with birth defects
Use of oral fluconazole for treatment of vulvovaginal candidiasis in the first trimester of pregnancy is associated with musculoskeletal malformations

Musculoskeletal Malformations Up With Fluconazole in Pregnancy

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But no increase seen in conotruncal malformations, oral clefts with use of oral fluconazole in first trimester
From 2003 to 2017

2003 to 2017 Saw Drop in Infant Mortality Due to Birth Defects

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Considerable variation found in the decrease, with smallest decline for infants born to black mothers