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Genetic variants in CYP2C8 and SLCO1B1 impact the therapeutic response to rosiglitazone in patients with type 2 diabetes

CYP2C8, SLCO1B1 Variants Impact Response to Rosiglitazone

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Genetic variants have clinical impact on response to rosiglitazone, but not pioglitazone
Patients with chronic myeloid leukemia who received a glitazone along with imatinib remained disease-free for up to nearly five years in a study published online Sept. 2 in Nature.

Addition of Glitazone to Chemo May Help Treat CML

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Combining glitazones with standard treatment improved survival in small study
Use of glitazones may help protect against Parkinson's disease

Glitazone Usage Tied to Lower Risk for Parkinson’s Disease

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Lower risk of Parkinson's seen only with current use of glitazone