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Initiating donepezil to manage symptoms of Alzheimer disease or other dementias is associated with a higher risk for 30-day admission to the hospital with rhabdomyolysis compared with initiating rivastigmine or galantamine

Donepezil Ups Risk for Hospital Admission for Rhabdomyolysis

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Donepezil linked to increased risk for admission with rhabdomyolysis versus rivastigmine, galantamine
Donepezil should not be prescribed to patients with mild cognitive impairment without first giving them a genetic test

Off-Label Donepezil Rx for MCI Could Be Risky for Some Patients

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Medication has detrimental effect on patients with the K-variant of the butyrylcholinesterase gene