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First-Generation Antihistamines Increase Risk for Seizures in Children

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Highest risk seen in young children aged 6 to 24 months

Administering antihistamine medication to a child experiencing anaphylaxis is associated with increased odds of a delay in seeking medical care

AAP: Antihistamine Use for Anaphylaxis May Delay Care Seeking

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Odds of delay seeking medical care up with administration of antihistamines to child with anaphylaxis
Patients receiving gastric acid inhibitors have an increase in prescriptions of anti-allergic drugs

Risk for Allergy Development Increased After Gastric Acid Inhibitor Use

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Rates ratios increased with increasing age and were more prominent in women
A contact lens-based drug delivery system is effective for therapeutic delivery of the antihistamine ketotifen

Contact Lens-Based Antihistamine Delivery Effective

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Eyes wearing lenses with etafilcon A, ketotifen have lower mean itching scores than controls
Daily intranasal corticosteroids (INCS) are not superior to on-demand INCS or to antihistamine on demand for the treatment of pollen-related allergies in children

Daily Intranasal Steroid Tx Not Better for Allergy Relief

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Findings based on number of symptom-free days for daily versus as-needed treatment
Histamine may contribute to exercise recovery in skeletal muscle

Do Antihistamines Blunt Exercise Recovery?

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Histamine blockade changes expression of genes that respond to exercise
Clemastine fumarate partially reverses optic neuropathy in patients with multiple sclerosis

AAN: Antihistamine May Help Reverse Optic Neuropathy in MS

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Vision improvement with clemastine fumarate appears modest but results are promising
Anthim (obiltoxaximab) has been approved by the U.S. Food and Drug Administration to treat inhalational anthrax.

FDA Approves Anthim for Treating Inhalation Anthrax

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Anthim, combined with certain antibacterial drugs, designed to neutralize anthrax toxins
U.S. Food and Drug Administration approval for the BioThrax anthrax vaccine has been expanded to include adults aged 18 to 65 with known or suspected exposure

FDA Expands Anthrax Vaccine Approval

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Now sanctioned for adults 18 to 65 with known or suspected exposure
Preliminary lab research suggests the antihistamine chlorcyclizine HCl that costs about 50 cents a pill has the potential to treat hepatitis C

Inexpensive Antihistamine Repurposed to Focus on HCV

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Lab tests suggest over-the-counter antihistamine could offer alternative to pricey new drugs