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Tag: Antidepressants

For patients undergoing total hip and total knee arthroplasty

AAOS: SSRI Use Linked to Lower Risk of Revision in THA, TKA

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Significantly lower risk of revisions, aseptic revisions; no reduction in risk of prosthetic joint infections
Antidepressant treatment efficacy varies for empirically-defined clusters of symptoms

Antidepressant Efficacy Varies for Depressive Symptom Clusters

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Most drugs more effective for core emotional symptoms than for sleep, atypical symptoms
Up to one-third of antidepressants are prescribed for pain

Off-Label Antidepressant Use Common, but Evidence Lacking

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Trazodone for insomnia most common off-label use for antidepressants
For patients with chronic depression

Panic Disorder May Up Odds of Depression Rx Side Effects

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Comorbid panic disorder tied to increased likelihood of side effects during treatment for depression
For older adults with late-life major depression

Antidepressants + Exercise Beneficial in Late-Life Depression

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Characteristics associated with remission for AD + PE include age 75 years and older, polypharmacy
Pharmacogenetic analysis can help optimize clomipramine doses in patients who do not respond to standard-dose treatment

Pharmacogenetic Analyses Can Optimize Clomipramine Dosing

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Case report of woman with depressive episode who did not respond to standard dose of clomipramine
Treatment for depression and anxiety is nearly twice as common among U.S. cancer survivors as it is for those with no history of cancer

Cancer Survivors Have Higher Rate of Antidepressant Use

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Nearly one in five survivors taking medication for depression or anxiety years later
In pregnant women taking the antidepressant bupropion

Researchers Find Antidepressant Bupropion Crosses Placenta

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Concentrations suggest higher fetal exposure to metabolites than the drug
Children whose mothers used a selective serotonin reuptake inhibitor during pregnancy may be more likely to develop speech and language disorders

SSRI Use During Pregnancy Tied to Speech Issues in Offspring

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No link found between SSRI use in pregnancy and risk of motor disorders, poor academic performance
Treating children and teens suffering from depression with antidepressants may be both ineffective and potentially dangerous

Review Finds Antidepressants Ineffective in Children, Teens

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Medications were seen as mostly ineffective and sometimes risky in these age groups