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Tag: Antidepressants

Among older adults

Antidepressant Use in Seniors Linked to Risk for Hip Fracture

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Odds ratio highest 16 to 30 days before Rx filled
The risk for atrial fibrillation is increased among antidepressant users

A-Fib Risk Up for Antidepressant Users, but Higher Before Tx

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Antidepressant treatment linked to threefold increased risk during first month; link decreased over year
Legacy prescribing of certain drugs

Failure of Timely Stop to Certain Prescription Drugs Is Common

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So-called legacy prescribing can contribute to overmedication and adverse drug events
The likelihood of using antidepressants may be increased for women who have abortions

Abortion Not Tied to Significantly Higher Antidepressant Use

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Risk factors associated with antidepressant use include previous antianxiety, antipsychotic meds
Antidepressant prescribing is associated with long-term increased risk of weight gain

Antidepressant Prescribing Linked to Lasting Weight Gain

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Risk of weight gain remained increased during at least six years of follow-up
Children with prenatal exposure to serotonin reuptake inhibitors have better executive function at age 12 years

Executive Function Improved With Prenatal Exposure to SSRIs

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Better EF skills in 12-year-olds exposed to prenatal SSRI, even controlling for maternal depressive sx
Prenatal exposure to a selective serotonin reuptake inhibitor is associated with fetal brain development

Prenatal Exposure to SSRI Tied to Fetal Brain Development

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Significant gray matter volume expansion in right amygdala and right insula in SSRI-exposed infants
A substantial proportion of non-pregnant women of childbearing age have untreated depression

Depression Seen in One in 20 Childbearing-Aged Women

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Yet, antidepressant use is low in those with minor and major depression
A low risk of serotonin syndrome is seen in association with concomitant use of triptans and selective serotonin reuptake inhibitor or selective norepinephrine reuptake inhibitor antidepressants

Low Risk of Serotonin Syndrome for Triptans + SSRI/SNRI

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Researchers question FDA advisory warning on risk of concomitant use
For adults with major depressive disorder

21 Reviewed Antidepressants Top Placebo for Major Depression

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Agomelatine, amitriptyline, escitalopram are among most effective agents in head-to-head trials