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Tag: Anticoagulants

Dabigatran is not superior to aspirin for preventing recurrent stroke in patients with recent history of embolic stroke of undetermined source

Dabigatran Does Not Beat Aspirin for Preventing Recurrent Stroke

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Efficacy similar to aspirin for preventing recurrent stroke after embolic stroke of undetermined source
The reversal agent

ASA: Reversal Agent Cuts Severe Bleeding With Factor Xa Inhibitors

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Bolus plus two-hour infusion of andexanet alfa cuts antifactor Xa activity by 92 percent
Certain lots of Roche Diagnostics test strips should not be used with CoaguChek test meter devices to check levels of the blood thinner warfarin because patients may get inaccurate results and be at risk for serious injury or death

Expanded Recall of Warfarin Level Monitoring Test Strips

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Inaccurate results may put patients at risk for serious injury or death
Endogenous thrombin potential may provide better information than anti-factor Xa in determining the best dosage for blood thinners among obese patients undergoing bariatric surgery

Assay Aids Anticoagulant Dosing of Obese Patients for Bariatric Sx

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Thrombin generation assay may allow more accurate determination of anticoagulation adequacy
For patients initiating oral anticoagulant therapy

Hospitalization for Upper GI Bleed Highest With Rivaroxaban

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Upper gastrointestinal bleeding hospitalization risk lower for anticoagulant tx with PPI cotherapy
Black patients with atrial fibrillation are less likely to receive direct-acting oral anticoagulants compared with white patients

Racial Disparities Seen in Use of Oral Anticoagulants for A-Fib

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When treated for atrial fibrillation, quality of anticoagulant use lower in blacks, Hispanics
There is variation in the net clinical benefit of anticoagulants based on variation in published atrial fibrillation stroke rates

Net Benefit of Anticoagulants for A-Fib Varies With Stroke Rate

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Benefit of warfarin anticoagulation varies with varying published stroke rates
Apixaban seems to be the safest direct oral anticoagulant compared with warfarin

Apixaban Is Safest Direct Oral Anticoagulant Versus Warfarin

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Reduced risks of major, intracranial, and gastrointestinal bleeding compared with warfarin
For an extended duration

Reduced-Dose Anticoagulants Feasible for Extended VTE Tx

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May be as effective as full-dose direct oral anticoagulants for extended-duration treatment
For stable warfarin-treated patients

Extended INR Test Intervals Safe for Warfarin-Treated Patients

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Similar number of out-of-range next INR values for patients with, without extended testing interval