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Tag: Anticoagulants

The combination of clopidogrel and aspirin is associated with reduced risk of major ischemic events but increased risk of major hemorrhage among patients with minor ischemic stroke or high-risk transient ischemic attack

Clopidogrel + Aspirin Cuts Ischemic Events in Stroke, TIA

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However, combination is associated with increased risk of major hemorrhage within 90 days
For older patients with concomitant chronic kidney disease and a new diagnosis of atrial fibrillation

Anticoagulants in Seniors With A-Fib, CKD Ups Stroke, ICH Risk

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Anticoagulants linked to increased risk of ischemic stroke and hemorrhage, but lower all-cause mortality
Clinical practice guidelines for anticoagulation therapy for cardiopulmonary bypass have been developed and were published in the February issue of the Annals of Thoracic Surgery.

Anticoagulation Guidance Issued for Cardiopulmonary Bypass

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Recommendations for heparin dosing and monitoring, contraindications and alternatives, reversal
Prasugrel carries no increased ocular risk compared with clopidogrel

Ocular Safety Profile of Novel Oral Antithrombotics Explored

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Prasugrel has no increased ocular risk versus clopidogrel; dabigatran, rivaroxaban may reduce risk
The addition of pharmacomechanical thrombolysis does not reduce the risk of post-thrombotic syndrome among patients with acute proximal deep vein thrombosis

Pharmacomechanical Thrombolysis No Benefit in DVT

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Addition of pharmacomechanical catheter-directed thrombolysis resulted in higher risk of bleeding
The chemical stability of warfarin sodium tablets is not affected by repackaging into dose administration aids

Storage in Dose Administration Aids Doesn’t Affect Warfarin

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Repackaging of warfarin sodium tablets into dose administration aids doesn't affect chemical stability
A decision pathway has been developed to guide management of acute bleeding in patients treated with oral anticoagulants; the decision pathway was published online Dec. 1 in the Journal of the American College of Cardiology.

ACC Guides Treatment of Bleeding With Oral Anticoagulation

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Pathway supports clinician decision making during management of patients with bleeding complications
For patients with atrial fibrillation

NOACs Show Lower Risk of Adverse Renal Outcomes in A-Fib

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Compared with warfarin, dabigatran and rivaroxaban linked to lower risk of adverse renal outcomes
Genotype-guided warfarin dosing is associated with reduced risk of adverse events compared with clinically-guided dosing among patients undergoing elective hip or knee arthroplasty

Genotype-Guided Warfarin Dosing Cuts Adverse Events

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Risk of composite of major bleeding, INR ≥4, VTE, death down for hip, knee arthroplasty patients
For elderly patients treated with vitamin K antagonists for venous thromboembolism

CYP2C9 Variants Linked to Clinical Events in VTE

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Risk of any clinical event, death, non-major bleeding up for seniors treated with vitamin K antagonists