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Tag: Anticoagulants

Black patients with atrial fibrillation are less likely to receive direct-acting oral anticoagulants compared with white patients

Racial Disparities Seen in Use of Oral Anticoagulants for A-Fib

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When treated for atrial fibrillation, quality of anticoagulant use lower in blacks, Hispanics
There is variation in the net clinical benefit of anticoagulants based on variation in published atrial fibrillation stroke rates

Net Benefit of Anticoagulants for A-Fib Varies With Stroke Rate

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Benefit of warfarin anticoagulation varies with varying published stroke rates
Apixaban seems to be the safest direct oral anticoagulant compared with warfarin

Apixaban Is Safest Direct Oral Anticoagulant Versus Warfarin

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Reduced risks of major, intracranial, and gastrointestinal bleeding compared with warfarin
For an extended duration

Reduced-Dose Anticoagulants Feasible for Extended VTE Tx

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May be as effective as full-dose direct oral anticoagulants for extended-duration treatment
For stable warfarin-treated patients

Extended INR Test Intervals Safe for Warfarin-Treated Patients

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Similar number of out-of-range next INR values for patients with, without extended testing interval
The combination of clopidogrel and aspirin is associated with reduced risk of major ischemic events but increased risk of major hemorrhage among patients with minor ischemic stroke or high-risk transient ischemic attack

Clopidogrel + Aspirin Cuts Ischemic Events in Stroke, TIA

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However, combination is associated with increased risk of major hemorrhage within 90 days
For older patients with concomitant chronic kidney disease and a new diagnosis of atrial fibrillation

Anticoagulants in Seniors With A-Fib, CKD Ups Stroke, ICH Risk

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Anticoagulants linked to increased risk of ischemic stroke and hemorrhage, but lower all-cause mortality
Clinical practice guidelines for anticoagulation therapy for cardiopulmonary bypass have been developed and were published in the February issue of the Annals of Thoracic Surgery.

Anticoagulation Guidance Issued for Cardiopulmonary Bypass

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Recommendations for heparin dosing and monitoring, contraindications and alternatives, reversal
Prasugrel carries no increased ocular risk compared with clopidogrel

Ocular Safety Profile of Novel Oral Antithrombotics Explored

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Prasugrel has no increased ocular risk versus clopidogrel; dabigatran, rivaroxaban may reduce risk
The addition of pharmacomechanical thrombolysis does not reduce the risk of post-thrombotic syndrome among patients with acute proximal deep vein thrombosis

Pharmacomechanical Thrombolysis No Benefit in DVT

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Addition of pharmacomechanical catheter-directed thrombolysis resulted in higher risk of bleeding