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Diagnostic Stewardship Cuts Blood Cultures, Antibiotic Use in PICU

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Relative reductions of 33 percent in rate of blood cultures, 13 percent in rate of broad-spectrum antibiotic use seen postimplementation

FDA Postpones Decision on Pfizer COVID Vaccine for Kids Under 5

Antibiotic Use in Under 2s May Reduce Antibody Response to Vaccines

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Possible negative association of history of antibiotic prescriptions with vaccine-induced immunity seen in young children

Azithromycin Therapy Does Not Reduce Recurrent Wheeze After RSV

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Azithromycin therapy during RSV bronchiolitis does not reduce the risk for post-RSV recurrent wheeze over two to four years

Treatment Strategy Studied for Drug Use-Linked Infective Endocarditis

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Clinical outcomes and cost-effectiveness of simulated treatment strategies for injection drug use-linked IE compared in modeling study

Early-Life Antibiotics Alter Infant Gut Microbiome

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Major shift seen in composition and in antimicrobial resistance gene profile directly after treatment, which normalized over 12 months

Nonantibiotic Prophylaxis Noninferior for Recurrent UTI

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Incidence of antibiotic-treated UTI during 12-month treatment period noninferior for methenamine hippurate versus prophylactic antibiotics

AHA Issues Advisory for Penicillin Reactions in Patients With Severe RHD

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Strongly consider oral prophylaxis for patients at elevated risk for cardiovascular compromise following IM injection of benzathine penicillin G

4.95 Million Deaths Linked to Antimicrobial Resistance in 2019

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Lower respiratory infections accounted for >1.5 million deaths associated with resistance, making it the most burdensome syndrome

Risk for Early-Onset Sepsis Low for Infants With Low-Risk Delivery

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Risk for early-onset sepsis low among infants of all gestational ages born with low-risk delivery characteristics

Prophylactic Antibiotics Not Needed Before Invasive Dental Procedures

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No evidence of temporal association seen between invasive dental procedure and late prosthetic joint infection