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Taking spironolactone alongside the antibiotic trimethoprim-sulfamethoxazole can cause blood potassium to rise to potentially life-threatening levels

Spironolactone + TMP-SMX May Up Risk of Sudden Death

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Doctors urged not to prescribe spironolactone with trimethoprim-sulfamethoxazole
High penicillin G prescribing may lead to an altered level of resistance in the commensal viridans group streptococci population

High Penicillin Prescribing Could Build Reservoirs of Resistance

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Significant difference in minimum inhibitory concentration for high, low prescribers of penicillin G
Utilization patterns indicate that antimicrobial prophylaxis is overused for urological surgeries in the community practice setting

Prophylactic Antimicrobials Overused in Urologic Surgery

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In community practice, overall rate of compliance with AUA Best Practices is less than 60 percent
The overuse of antibiotics to treat travelers' diarrhea may contribute to the spread of drug-resistant superbugs

Overuse of Abx for Travelers’ Diarrhea Creating Superbugs

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Researchers recommend caution when using antibiotics to treat digestive ills while abroad
For children with community-acquired pneumonia

No Negative Consequences of Guidelines for Antibiotic Therapy

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No change in length of stay, total costs, inpatient pharmacy costs among children with pneumonia