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Most emergency visits by children occur at nonpediatric emergency departments

Antibiotics Prescribed for Children More Often at Nonpediatric EDs

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Frequency of guideline-concordant prescribing for respiratory conditions lower at nonpediatric EDs
Patients taking fluoroquinolones may be at higher risk for ruptures or tears in the aorta

FDA: Fluoroquinolones Tied to Heart Vessel Ruptures, Tears

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Patients at risk include those with hypertension or certain genetic disorders and the elderly
Antibiotic use in children <24 months of age is associated with a slightly higher body weight at 5 years of age

Early Antibiotic Use May Be Tied to Higher Childhood Body Weight

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Antibiotics before age 2 associated with very small increase in body weight at 5 years of age
Following the 2007 American Heart Association update of recommendations for antibiotic prophylaxis (AP) to prevent infective endocarditis (IE)

AHA: After 2007 Recs, Increase Seen in Infective Endocarditis

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Twenty percent drop in antibiotic prophylaxis, 177 percent increase in IE incidence for high-risk
Almost half of parents report saving leftover antibiotics

AAP: Parents Frequently Save Leftover Antibiotics

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Almost three-quarters of those saving antibiotics subsequently divert the antibiotics to others
Prescription of antibiotics and acid-suppressing medications in early childhood is associated with an increased risk for obesity

Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk

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Prescription of antibiotics, acid-suppressing meds in first two years of life linked to childhood obesity
For complicated urinary tract infections caused by multidrug-resistant Gram-negative uropathogens

In Complicated UTI, Cefiderocol Noninferior to Imipenem-Cilastin

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Results from phase 2 study in patients with multidrug-resistant Gram-negative uropathogens
For patients with staphylococcal bacteremia

Algorithm-Defined Tx Duration Non-Inferior in Staph Bacteremia

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Non-inferior rate of clinical success for algorithm defining treatment duration versus usual care
There is considerable variability in the geographic availability of antibiotics

Variability in Geographic Availability of New Antibiotics

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Greater geographic availability for antibiotics from and/or marketed by companies in U.S., Europe
For infants with uncomplicated

Low Recurrence With Shortened IV Abx Course in GBS Bacteremia

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Some infants with late-onset GBS bacteremia treated with shortened course of IV antibiotics