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Prescription of antibiotics and acid-suppressing medications in early childhood is associated with an increased risk for obesity

Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk

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Prescription of antibiotics, acid-suppressing meds in first two years of life linked to childhood obesity
For complicated urinary tract infections caused by multidrug-resistant Gram-negative uropathogens

In Complicated UTI, Cefiderocol Noninferior to Imipenem-Cilastin

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Results from phase 2 study in patients with multidrug-resistant Gram-negative uropathogens
For patients with staphylococcal bacteremia

Algorithm-Defined Tx Duration Non-Inferior in Staph Bacteremia

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Non-inferior rate of clinical success for algorithm defining treatment duration versus usual care
There is considerable variability in the geographic availability of antibiotics

Variability in Geographic Availability of New Antibiotics

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Greater geographic availability for antibiotics from and/or marketed by companies in U.S., Europe
For infants with uncomplicated

Low Recurrence With Shortened IV Abx Course in GBS Bacteremia

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Some infants with late-onset GBS bacteremia treated with shortened course of IV antibiotics
In a direct-to-consumer telemedicine setting

Telemedicine RTI Visits Shorter When Antibiotic Prescribed

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Finding may highlight physician difficulty explaining to patients why antibiotics are not required
The cumulative incidence of appendicitis recurrence within five years is 39.1 percent among patients with uncomplicated acute appendicitis initially treated with antibiotics

Initial Abx Feasible Alternative for Uncomplicated Appendicitis

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At five years, cumulative incidence of appendicitis recurrence 39.1 percent with antibiotic treatment
Antibiotic use rates in neonatal intensive care units are declining

NICU Antibiotic Use Rates Declined From 2013 to 2016

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Variance in rates mostly unexplained by proven infections, other clinical indications
Very young children with urinary tract infections who receive parenteral antibiotics before emergency department discharge do not have lower rates of revisits leading to admission than children receiving oral antibiotics

Pediatric Revisits, Admissions for UTI Similar With Oral or IV Meds

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Findings support ED discharge with oral antibiotics for children with urinary tract infection
Changing from intravenous to oral antibiotic treatment is non-inferior to continued intravenous antibiotic treatment among patients with endocarditis on the left side of the heart

Partial Oral Abx Non-Inferior in Endocarditis on Left Side of Heart

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Changing to oral antibiotics was non-inferior to continued intravenous antibiotic treatment