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For patients being treated for bone or joint infection

Oral Antibiotics Noninferior to IV for Bone, Joint Infection

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Noninferiority in intention-to-treat analysis; supported by complete-case, per-protocol, sensitivity analysis
Less than half of all outpatient antibiotic prescription fills by privately insured nonelderly adults and children in the United States are appropriate or potentially appropriate

Inappropriate Antibiotic Rx Common in Privately Insured

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Only 12.8 and 35.5 percent of fills were appropriate, potentially appropriate in outpatients
Most children younger than 2 years with bronchiolitis seen in U.S. emergency departments and prescribed antibiotics have no documented bacterial coinfection

Antibiotics Often Inappropriately Prescribed for Bronchiolitis in ED

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In almost 70 percent of bronchiolitis cases, antibiotics prescribed with no concomitant infection
A new review

Review Shares Best Practices for Evaluating Penicillin Allergy

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Verifying reported allergies necessary to improve outcomes, prevent antibiotic resistance
Dermatologists' use of antibiotics to treat inflammatory skin conditions like acne and rosacea is decreasing

Dermatologists’ Rx for Antibiotics Dropped From 2008 to 2016

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However, rising use of antibiotics after dermatologic surgical visits is concerning
Most emergency visits by children occur at nonpediatric emergency departments

Antibiotics Prescribed for Children More Often at Nonpediatric EDs

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Frequency of guideline-concordant prescribing for respiratory conditions lower at nonpediatric EDs
Patients taking fluoroquinolones may be at higher risk for ruptures or tears in the aorta

FDA: Fluoroquinolones Tied to Heart Vessel Ruptures, Tears

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Patients at risk include those with hypertension or certain genetic disorders and the elderly
Antibiotic use in children <24 months of age is associated with a slightly higher body weight at 5 years of age

Early Antibiotic Use May Be Tied to Higher Childhood Body Weight

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Antibiotics before age 2 associated with very small increase in body weight at 5 years of age
Following the 2007 American Heart Association update of recommendations for antibiotic prophylaxis (AP) to prevent infective endocarditis (IE)

AHA: After 2007 Recs, Increase Seen in Infective Endocarditis

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Twenty percent drop in antibiotic prophylaxis, 177 percent increase in IE incidence for high-risk
Almost half of parents report saving leftover antibiotics

AAP: Parents Frequently Save Leftover Antibiotics

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Almost three-quarters of those saving antibiotics subsequently divert the antibiotics to others