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Three months of azithromycin did not significantly reduce treatment failure among patients hospitalized for an acute exacerbation of chronic obstructive pulmonary disease

Impact of Azithromycin Studied in Acute Exacerbation of COPD

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Azithromycin leads to significant drops in treatment intensification and step-up in hospital care
For women in middle and late adulthood

Longer Duration of Antibiotic Use Tied to Risk for CVD in Women

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Risk for cardiovascular disease increased for women in middle, late adulthood with longer antibiotic use
For children with acute respiratory infections

Telemedicine Leads to More Antibiotic Rx for Pediatric Respiratory Infection

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More antibiotics prescribed with less guideline-concordant antibiotic management versus other settings
Recommendations have been developed for use of polymyxins

Guidelines Developed for Polymyxin Antibiotic Use

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Polymyxin B recommended for routine use in invasive infections; colistin preferred for lower UTI
The U.S. Environmental Protection Agency proposal to allow use of the antibiotic streptomycin to treat citrus disease should be withdrawn because it poses a risk to human health and the environment

EPA Proposal Will Allow Antibiotic Spraying of Citrus Crops

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Consumer Reports warns of '26-fold increase in the use of streptomycin in plant agriculture'
Delaying or withholding antibiotics for older patients with a urinary tract infection is associated with an increase in bloodstream infection and all-cause mortality

Antibiotic Delay Leads to Increased Risks in Seniors With UTI

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No antibiotics, deferred antibiotics tied to increase in bloodstream infection, all-cause mortality
Fluoroquinolone stewardship interventions at hospitals are associated with less fluoroquinolone prescribing during hospitalization but not at discharge

Stewardship Programs Decrease Inpatient Fluoroquinolone Rx

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Interventions tied to less prescribing in hospital but did not impact fluoroquinolone discharge treatment
Plazomicin is noninferior to meropenem for patients with complicated urinary tract infections

Plazomicin Noninferior to Meropenem for Complicated UTI

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In second study, plazomicin may be beneficial for carbapenem-resistant Enterobacteriaceae infections
Although there has been progress in the development of new antibacterial drugs

Progress Made in Developing New Antibacterial Agents

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But most recently approved agents have been modifications of existing chemical classes of antibiotics
Omadacycline is noninferior to moxifloxacin for community-acquired bacterial pneumonia and noninferior to linezolid for acute bacterial skin infections

Omadacycline Noninferior to Moxifloxacin for Pneumonia

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Second study shows noninferiority to linezolid for acute bacterial skin and skin-structure infections