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Risk Factors ID’d for Lower-Limb Amputation for PAD in Urban Areas

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In metropolitan areas, lower median household income and higher Distressed Communities Index score tied to increased amputation rate

Toe, Foot Amputations Increasing in Minorities, Rural Residents With Diabetes

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Rates of minor lower-extremity amputations rising among Asian/Pacific Islanders

Rates of Reamputation High in Patients With Diabetes

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Rates of reamputation have not changed for at least two decades

Panel Recommends Against Approval of Experimental Drug for Alzheimer Disease

FDA Approves Implant System for Transfemoral Amputations

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The OPRA Implant System is surgically anchored and integrated into a patient's remaining thigh bone

For patients with type 2 diabetes

Short-Term Risk for Below-Knee Amputation Not Increased With SGLT2i

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Risk for below-knee amputation not increased versus DPP-4 inhibitor use in patients with type 2 diabetes
Since 2009

Diabetes-Related Lower-Limb Amputations Up in Older Adults

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Absolute rates for amputation among Medicare beneficiaries highest in oldest old, blacks, men
Diabetes-related lower-extremity complications are a large and increasing contributor to the global burden of disability

Diabetes-Related Lower-Extremity Complications Increasing

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In 2016, 1.8 percent of global population had DRLECs, which increased from 1990 estimates
For patients with critical limb ischemia

First Surgery for Ischemic Leg Ulcer May Affect Amputation Risk

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But mortality did not differ for initial treatment with open surgical bypass or endovascular intervention
Microvascular disease increases the risk for amputation alone and in combination with peripheral artery disease

Risk for Leg Amputation Higher With Microvascular Disease

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Risk higher regardless of microvascular disease location or other blood vessel conditions
Decreases in nontraumatic lower-extremity amputation have plateaued in recent years among adults with end-stage renal disease and diabetes

Decline in Nontraumatic Lower-Extremity Amputation Slowing

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Decline in NLEA among patients with end-stage renal disease with diabetes stabilized since 2013