Tag: Alzheimer’s
Gantenerumab Does Not Slow Clinical Decline in Early Alzheimer Disease
Two trials show lower amyloid plaque burden with gantenerumab versus placebo at 116 weeks
Earlier Onset of A-Fib Linked to Risk of Developing All-Cause Dementia
Younger age at a-fib onset linked to increased risks of all-cause and vascular dementia, Alzheimer disease
Stress, Depression Linked to MCI, Alzheimer Disease
Chronic stress and depression are independent risk factors and have an additive effect when combined
Minor Neuropsychological Deficits Indicate Risk for Progression to Alzheimer Disease
For patients with subjective cognitive decline, those with minor neuropsychological deficits have increased cognitive decline, risk for progression to MCI
Shorter Leucocyte Telomere Length Linked to Dementia Risk
Shorter leucocyte telomere length also associated with smaller total brain volume, white matter volume, hippocampus volume
Antipsychotic Use Increased for Seniors With Alzheimer, Related Dementias
Among patients with ADRD receiving care from a home health agency, antipsychotic use was tied to less improvement in activities of daily living
Alzheimer, Parkinson Disease Share Protective Association at HLA Locus
Protective HLA-DRB1*04 subtypes bind strongly to aggregation-prone tau PHF6 sequence when acetylated at K311
Panel of 48 CSF Proteins Complements Existing Alzheimer Biomarkers
CSF 48 panel plus existing biomarkers significantly improved diagnostic performance for outcomes studied
Routine Vaccines Can Cut Risk for Later Alzheimer Disease
Findings seen for tetanus and diphtheria, shingles, and pneumococcus vaccines
Eligibility Limited for Anti-β Amyloid mAbs in Seniors With MCI
Few older adults with MCI or mild dementia were eligible for lecanemab, aducanumab after applying clinical trial criteria
