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Tag: Alzheimer’s

Undetected seizures may contribute to some symptoms associated with Alzheimer's disease

Silent Seizures May Contribute to Alzheimer’s Pathology

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Early occult hippocampal hyperexcitability may contribute to pathogenesis of AD, researchers say
Discontinuation of acetylcholinesterase inhibitors for treatment of Alzheimer's disease is common

Many Patients With Alzheimer’s Disease Discontinue AChEIs

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Adverse effects and cost account for most cases of discontinuation
Having a mental health disorder doesn't translate into a higher risk of Alzheimer's disease later in life

Past Psychiatric Disorders Do Not Raise Risk of Alzheimer’s Disease

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But more recent psychiatric symptoms may be part of the disease
Alzheimer's disease claims nearly twice as many American lives annually as it did just 15 years ago

Five Million American Seniors Now Living With Alzheimer’s

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Price tag hits $259 billion a year; projected to exceed $1 trillion by 2050
A diagnosis of mild cognitive impairment is frequently associated with comorbid neuropathologies

Comorbid Neuropathies Common With MCI Diagnosis

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Mixed Alzheimer's disease neuropathic changes more frequent than pure ADNC among those with MCI
Women who use hormone therapy after menopause may not have a lower risk of developing Alzheimer's disease

Hormone Therapy Doesn’t Appear to Protect Against Alzheimer’s

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Possible benefit for long-term hormone therapy, but results not definitive
Developing hypertension in very old age may provide some protection from dementia

Hypertension Onset After Age 80 May Protect Against Dementia

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Association independent of antihypertensive medication use
Concussions may be associated with accelerated cortical thickness and memory decline in Alzheimer's disease-relevant areas

Concussions May Accelerate Alzheimer’s Disease Progression

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Brain trauma seems to speed up mental decline in patients at genetic risk for Alzheimer's
Effectiveness of statin use in Alzheimer's prevention may depend on the specific statin

Effect of Statins on Alzheimer’s May Depend on Gender, Race

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Type of statin used also makes a difference; no benefit seen for black men
Amyloid beta deposits in Alzheimer's patients might also negatively affect their heart muscle and increase their risk of heart failure

Amyloid Beta Deposits Can Affect Hearts of Alzheimer’s Patients

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Deposits can lead to compromised myocardial function