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Tag: Alzheimer’s

People who work in jobs that task the intellect are better able to withstand the effects of brain lesions commonly associated with Alzheimer's disease

AAIC: Intellectually-Stimulating Jobs May Lower Alzheimer’s Risk

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Activities that highly stimulate the brain might build up 'reserve' to help ward off dementia
Variations in the APOE gene may start to show effects on brain structure and mental acuity as early as preschool

Effects of APOE Gene May Be Apparent in Childhood

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Findings may lead to earlier interventions, preventive measures for future brain injuries, dementia
A genetic test may one day be able to predict the risk for Alzheimer's disease in young adults

Risk Score Could Help ID Alzheimer’s Risk in Young Adults

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Score also associated with worse memory, clinical progression in older adults
Patients in the early stages of Alzheimer's disease may have more leakages in the blood-brain barrier

Blood-Brain Barrier Leaks Seen in Patients With Early Alzheimer’s

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Cognitive abilities decreased significantly with increasing leakage in deep gray matter
Men who experience the loss of chromosome Y from their blood cells as they age may have an increased risk of developing Alzheimer's disease

Loss of Y Chromosome in Blood Tied to Alzheimer’s Risk in Men

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The greater the Y chromosome loss, the higher the risk of developing Alzheimer's, researchers say
Plasma homocysteine and its metabolite homocysteine thiolactone contribute to Alzheimer's disease pathology via the amyloid-β-fibrinogen interaction

Homocysteine Tied to Alzheimer’s Via Aβ-Fibrinogen Interaction

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Elevated levels of plasma HC/HCTL contribute to Alzheimer's pathology via Aβ-fibrinogen interaction
The first case of Alzheimer's disease (AD) diagnosed in a person with HIV suggests progressive dementia in older HIV+ individuals may be due to HIV-associated neurocognitive disorder

Novel Case of Alzheimer’s Reported in HIV+ Patient

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Amyloid PET imaging may help distinguish AD from HIV-associated neurocognitive disorder
Autosomal dominant Alzheimer's disease is associated with increased white matter hyperintensities on magnetic resonance imaging well before expected symptom onset

White Matter Hyperintensities Predate Alzheimer’s Onset

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White matter hyperintensity volume differences seen six years before symptoms
Neuronal heparan sulfates modulate brain amyloid-β clearance and aggregation in a mouse model of Alzheimer's disease

Neuronal Heparan Sulfates Play Role in Amyloid Pathology

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Removal of neuronal HS linked to reduction in Aβ oligomerization and deposition of amyloid plaques
Intellectual enrichment (high education and high midlife cognitive activity) has effects on biomarkers of Alzheimer's disease in older adults

Active Mind May Delay Alzheimer Symptoms, but Not Disease

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High midlife cognitive activity tied to lower amyloid deposition in APOE4 carriers with high education