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Tag: Alzheimer’s

A new approach to getting drugs through the blood-brain barrier in Alzheimer's patients shows early promise

Focused Ultrasound May Briefly Open Blood-Brain Barrier

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Finding could be a game-changer for the treatment of neurological diseases such as Alzheimer's
The lifetime risks of Alzheimer's disease dementia vary considerably by age

Lifetime Risks Temper Biomarker Tests for Alzheimer Dz Dementia

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Those younger than 85 years with MCI, amyloidosis, neurodegeneration have risk >50 percent
The correlation between the apolipoprotein E (APOE) gene allele APOE-ε4 and cerebrospinal fluid tau levels is stronger among women than men

Women Have Stronger Link Between APOE-ε4, CSF Tau Levels

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Sex differences were not seen in the correlation between APOE and neurofibrillary tangle burden
A primary mechanism for APOE gene-mediated plaque formation may result from apoE aggregation

apoE Aggregation May Impact apoE-Mediated Plaque Formation

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Anti-human apoE-4 antibody preferentially binds unlipidated aggregated apoE over lipidated version
Having more nurses in the hospital with at least a bachelor of science degree in nursing is tied to lower post-surgical mortality among patients with Alzheimer's disease and related dementias

Nurse Education Improves Post-Op Survival in Dementia Patients

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Findings show lower post-surgical mortality among patients with Alzheimer's disease
U.S. adults express concerns about discrimination by employers and insurance for patients with Alzheimer's disease dementia

Concern for Employer, Insurance Discrimination for Alzheimer’s Patients

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About half of adults surveyed expect a man with mild Alzheimer's dementia to be discriminated against
Short-term proton pump inhibitor use

Short-Term PPIs Tied to Higher Hip Fracture Risk in Alzheimer’s

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No association seen with long-term or cumulative proton pump inhibitor use in Alzheimer's patients
For young adults with autosomal dominant Alzheimer's disease

Molecular Markers May ID Alzheimer’s Before Clinical Onset

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Amyloid-positive PSEN1 E280A mutation carriers have elevated levels of tau deposition before onset
Pimavanserin is efficacious at six weeks for patients with Alzheimer's disease psychosis but not at 12 weeks

Pimavanzserin Cuts Alzheimer’s Psychosis at Six Weeks

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Significantly greater reduction in NPI-NH psychosis score at 6 weeks versus placebo, but not at 12 weeks
Sustained and increasing BACE1 inhibition can reverse amyloid deposition in a mouse model of Alzheimer's disease

In Alzheimer’s, BACE1 Inhibition May Reverse Amyloid Deposition

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Sequential, increased deletion of BACE1 in adult AD mouse model reversed amyloid deposition