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American Academy of Ophthalmology, Oct. 27-30

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The 122nd Annual Meeting of the American Academy of Ophthalmology The annual meeting of the American Academy of Ophthalmology was held from Oct....
The Alzheimer's Association has released appropriate-use criteria for lumbar puncture and cerebrospinal fluid testing in Alzheimer's disease diagnosis

Guidelines Presented for Lumbar Puncture in Alzheimer’s Dx

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Workgroup ID'd six indications as appropriate for lumbar puncture, cerebrospinal fluid testing
Hospitalization is associated with lower white matter integrity among older adults

Hospitalization Tied to Brain Abnormalities in Older Adults

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Critical illness, major infection linked to smaller brain volumes, especially region implicated in Alzheimer's
Even among individuals at high genetic risk for Alzheimer's disease

Exercise May Delay Symptoms of Alzheimer’s in Those at Risk

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Findings among individuals with a genetic mutation known to cause Alzheimer's
Age

Age, Sex, APOE Genotype Identify Alzheimer’s, Dementia Risk

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Three factors help identify absolute 10-year risk of Alzheimer's disease, all dementia for different groups
The burden of Alzheimer's disease and related dementias is expected to increase to 3.3 percent in the United States by 2060

Prevalence of Alzheimer’s, Related Dementia Set to Double

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Alzheimer's disease and related dementias burden is expected to increase to 3.3 percent in 2060
Retinal microvascular abnormalities are identified in cognitively healthy individuals who have biomarkers positive for Alzheimer's disease

Retinal Abnormalities May Indicate Preclinical Alzheimer’s

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Retinal microvascular abnormalities seen in cognitively normal individuals with biomarkers for AD
Positron emission tomographic imaging can directly measure synaptic loss with Alzheimer's disease

PET Imaging Can Measure Synaptic Loss From Alzheimer’s

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Team found SV2A-specific binding correlated with memory
Subjects with Alzheimer's disease have increased levels of two strains of human herpesvirus

Increased Levels of Human Herpesvirus ID’d in Alzheimer’s

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Disruption of molecular, genetic, clinical networks by human herpesvirus in brains of subjects with AD
An experimental drug appears to slow mental decline by as much as 30 percent in Alzheimer's disease patients

Experimental Drug Slows Mental Decline in Alzheimer’s Patients

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However, the Phase 2 study of BAN2401 did not meet its primary end point