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Tag: Alzheimer’s

The correlation between the apolipoprotein E (APOE) gene allele APOE-ε4 and cerebrospinal fluid tau levels is stronger among women than men

Women Have Stronger Link Between APOE-ε4, CSF Tau Levels

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Sex differences were not seen in the correlation between APOE and neurofibrillary tangle burden
A primary mechanism for APOE gene-mediated plaque formation may result from apoE aggregation

apoE Aggregation May Impact apoE-Mediated Plaque Formation

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Anti-human apoE-4 antibody preferentially binds unlipidated aggregated apoE over lipidated version
Having more nurses in the hospital with at least a bachelor of science degree in nursing is tied to lower post-surgical mortality among patients with Alzheimer's disease and related dementias

Nurse Education Improves Post-Op Survival in Dementia Patients

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Findings show lower post-surgical mortality among patients with Alzheimer's disease
U.S. adults express concerns about discrimination by employers and insurance for patients with Alzheimer's disease dementia

Concern for Employer, Insurance Discrimination for Alzheimer’s Patients

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About half of adults surveyed expect a man with mild Alzheimer's dementia to be discriminated against
Short-term proton pump inhibitor use

Short-Term PPIs Tied to Higher Hip Fracture Risk in Alzheimer’s

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No association seen with long-term or cumulative proton pump inhibitor use in Alzheimer's patients
For young adults with autosomal dominant Alzheimer's disease

Molecular Markers May ID Alzheimer’s Before Clinical Onset

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Amyloid-positive PSEN1 E280A mutation carriers have elevated levels of tau deposition before onset
Pimavanserin is efficacious at six weeks for patients with Alzheimer's disease psychosis but not at 12 weeks

Pimavanzserin Cuts Alzheimer’s Psychosis at Six Weeks

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Significantly greater reduction in NPI-NH psychosis score at 6 weeks versus placebo, but not at 12 weeks
Sustained and increasing BACE1 inhibition can reverse amyloid deposition in a mouse model of Alzheimer's disease

In Alzheimer’s, BACE1 Inhibition May Reverse Amyloid Deposition

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Sequential, increased deletion of BACE1 in adult AD mouse model reversed amyloid deposition
For patients with Alzheimer's disease

Deep Brain Stimulation May Be Promising Alzheimer’s Treatment

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DBS at ventral capsule/ventral striatum linked to less decline on Clinical Dementia Rating-Sum of Boxes
For patients with mild Alzheimer's disease

Solanezumab Doesn’t Affect Cognitive Decline in Alzheimer’s

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No difference between the drug and placebo in change in ADAS cognitive subscale score at week 80