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Age, Sex, APOE Genotype Identify Alzheimer’s, Dementia Risk

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Three factors help identify absolute 10-year risk of Alzheimer's disease, all dementia for different groups
The burden of Alzheimer's disease and related dementias is expected to increase to 3.3 percent in the United States by 2060

Prevalence of Alzheimer’s, Related Dementia Set to Double

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Alzheimer's disease and related dementias burden is expected to increase to 3.3 percent in 2060
Retinal microvascular abnormalities are identified in cognitively healthy individuals who have biomarkers positive for Alzheimer's disease

Retinal Abnormalities May Indicate Preclinical Alzheimer’s

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Retinal microvascular abnormalities seen in cognitively normal individuals with biomarkers for AD
Positron emission tomographic imaging can directly measure synaptic loss with Alzheimer's disease

PET Imaging Can Measure Synaptic Loss From Alzheimer’s

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Team found SV2A-specific binding correlated with memory
Subjects with Alzheimer's disease have increased levels of two strains of human herpesvirus

Increased Levels of Human Herpesvirus ID’d in Alzheimer’s

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Disruption of molecular, genetic, clinical networks by human herpesvirus in brains of subjects with AD
An experimental drug appears to slow mental decline by as much as 30 percent in Alzheimer's disease patients

Experimental Drug Slows Mental Decline in Alzheimer’s Patients

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However, the Phase 2 study of BAN2401 did not meet its primary end point
A new approach to getting drugs through the blood-brain barrier in Alzheimer's patients shows early promise

Focused Ultrasound May Briefly Open Blood-Brain Barrier

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Finding could be a game-changer for the treatment of neurological diseases such as Alzheimer's
The lifetime risks of Alzheimer's disease dementia vary considerably by age

Lifetime Risks Temper Biomarker Tests for Alzheimer Dz Dementia

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Those younger than 85 years with MCI, amyloidosis, neurodegeneration have risk >50 percent
The correlation between the apolipoprotein E (APOE) gene allele APOE-ε4 and cerebrospinal fluid tau levels is stronger among women than men

Women Have Stronger Link Between APOE-ε4, CSF Tau Levels

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Sex differences were not seen in the correlation between APOE and neurofibrillary tangle burden
A primary mechanism for APOE gene-mediated plaque formation may result from apoE aggregation

apoE Aggregation May Impact apoE-Mediated Plaque Formation

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Anti-human apoE-4 antibody preferentially binds unlipidated aggregated apoE over lipidated version