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Tag: Alzheimer’s

Community-dwelling patients with Alzheimer disease experience a lower risk for fractures

Thiazide Use May Lower Fracture Risk in Patients With Alzheimer Disease

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Longer thiazide use tied to decreased risk for low-energy fractures, hip fractures in Alzheimer disease
Naproxen sodium twice daily is not associated with reduced progression of presymptomatic Alzheimer disease among cognitively intact people at risk for the condition

Naproxen Sodium Does Not Slow Presymptomatic Alzheimer Disease

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Study shows increased frequency of adverse events but little impact on rate of change in APS
Low scam awareness is associated with an increased risk for Alzheimer disease and mild cognitive impairment among older adults

Low Scam Awareness May Indicate Alzheimer Risk in Seniors

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Increased risk for Alzheimer dementia, mild cognitive impairment seen with low scam awareness in seniors
Antiepileptic drug use may increase the risk for pneumonia in patients with Alzheimer disease

AEDs Tied to Higher Pneumonia Risk in Alzheimer Patients

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Risk for pneumonia highest within first month of antiepileptic drug use but persists through two years
Use of the orally administered β-site amyloid precursor protein-cleaving enzyme 1 inhibitors

Verubecestat, Atabecestat Not Beneficial for Preventing Alzheimer Disease

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Two trials show lack of effectiveness versus placebo for preclinical Alzheimer disease
For Medicare beneficiaries with mild cognitive impairment or dementia of uncertain etiology

Amyloid PET Linked to Changes in Management for MCI, Dementia

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Change in management between pre-, post-PET visits for 60.2 and 63.5 percent with MCI, dementia
Patients with poor cognitive function have significantly lower levels of Alzheimer disease-related biomarkers in the vitreous humor

Ocular Protein Levels May Be Useful for Alzheimer Testing

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Low levels of protein biomarkers amyloid-β and tau protein in vitreous humor tied to low cognitive scores
A higher number of vascular risk factors is associated with poorer brain health across gray and white matter macrostructure and microstructure

More Vascular Risk Factors Tied to Worse Brain Health

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Most consistent associations across brain measures seen with smoking pack years, hypertension, DM
Having affected first-degree

Having Affected Relatives Linked to Increased Alzheimer Risk

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Increased Alzheimer disease risk seen with having affected first-, second-, or third-degree relatives
Individuals with Alzheimer disease have changes in the retinal microvasculature in the superficial capillary plexus compared with those with mild cognitive impairment and controls

Retinal Microvascular Changes Identified in Alzheimer Disease

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Changes in retinal microvasculature in superficial capillary plexus observed compared with MCI, controls