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Tag: Alzheimer’s

For older adults on the Alzheimer disease trajectory

Early Tau Deposition Elevated for Women Versus Men

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Clinically normal women exhibit higher entorhinal cortical tau, which is linked to higher Aβ burden
In older adults

High Levels of Activity, Motor Ability Linked to Better Cognition

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Findings seen in older adults; independent correlations remained for those with Alzheimer disease
Older people who have less slow wave sleep have higher levels of the brain protein tau

Less Deep Sleep in Elderly Tied to Alzheimer Disease Markers

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Poor-quality sleep in later life could be a noninvasive marker for deteriorating brain health
Certain molecular biomarkers for Alzheimer's disease differ with race

Racial Differences ID’d in Some Biomarkers of Alzheimer’s Disease

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African-Americans have lower mean CSF concentration of total tau, phosphorylated tau181
Both restrictive and obstructive lung disease are associated with an increased risk for incident dementia and mild cognitive impairment

Restrictive, Obstructive Lung Disease Linked to Dementia Risk

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Associations seen for both Alzheimer's disease-related dementia and cerebrovascular etiologies
Modifying diagnostic criteria to require impairment on at least two memory tests for mild cognitive impairment diagnosis can improve prediction of medial temporal atrophy and conversion to Alzheimer's disease

Modifying Criteria for Amnestic MCI Dx Increases Prognostic Accuracy

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Requiring impairment on two memory tests improves prediction of brain atrophy and progression to AD
Fluorine 18 fluorodeoxyglucose positron emission tomography of the brain can be used to develop a deep learning algorithm for early prediction of Alzheimer's disease that has high specificity and sensitivity

18F-FDG PET Algorithm Allows Early Prediction of Alzheimer’s

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Deep learning model achieved 82 percent specificity, 100 percent sensitivity 75.8 months prediagnosis
Individuals with Alzheimer's disease have abnormalities and reductions in gene expression in the parahippocampal gyri that map to genes associated with the insulin receptor signaling pathway

Abnormalities in Genes Linked to IRSP in Alzheimer’s Disease

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Abnormalities, reductions in gene expression associated with insulin receptor signaling pathway

American Academy of Ophthalmology, Oct. 27-30

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The 122nd Annual Meeting of the American Academy of Ophthalmology The annual meeting of the American Academy of Ophthalmology was held from Oct....
The Alzheimer's Association has released appropriate-use criteria for lumbar puncture and cerebrospinal fluid testing in Alzheimer's disease diagnosis

Guidelines Presented for Lumbar Puncture in Alzheimer’s Dx

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Workgroup ID'd six indications as appropriate for lumbar puncture, cerebrospinal fluid testing