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Tag: Alzheimer’s

Antiepileptic drug use may increase the risk for pneumonia in patients with Alzheimer disease

AEDs Tied to Higher Pneumonia Risk in Alzheimer Patients

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Risk for pneumonia highest within first month of antiepileptic drug use but persists through two years
Use of the orally administered β-site amyloid precursor protein-cleaving enzyme 1 inhibitors

Verubecestat, Atabecestat Not Beneficial for Preventing Alzheimer Disease

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Two trials show lack of effectiveness versus placebo for preclinical Alzheimer disease
For Medicare beneficiaries with mild cognitive impairment or dementia of uncertain etiology

Amyloid PET Linked to Changes in Management for MCI, Dementia

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Change in management between pre-, post-PET visits for 60.2 and 63.5 percent with MCI, dementia
Patients with poor cognitive function have significantly lower levels of Alzheimer disease-related biomarkers in the vitreous humor

Ocular Protein Levels May Be Useful for Alzheimer Testing

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Low levels of protein biomarkers amyloid-β and tau protein in vitreous humor tied to low cognitive scores
A higher number of vascular risk factors is associated with poorer brain health across gray and white matter macrostructure and microstructure

More Vascular Risk Factors Tied to Worse Brain Health

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Most consistent associations across brain measures seen with smoking pack years, hypertension, DM
Having affected first-degree

Having Affected Relatives Linked to Increased Alzheimer Risk

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Increased Alzheimer disease risk seen with having affected first-, second-, or third-degree relatives
Individuals with Alzheimer disease have changes in the retinal microvasculature in the superficial capillary plexus compared with those with mild cognitive impairment and controls

Retinal Microvascular Changes Identified in Alzheimer Disease

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Changes in retinal microvasculature in superficial capillary plexus observed compared with MCI, controls
Long-term use of systemic hormone therapy may be associated with an increased risk for Alzheimer disease

Long-Term Systemic Hormone Therapy May Up Alzheimer Risk

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Risk increases associated with hormone therapy exposure over 10 years in women <60 years at initiation
Only 16 percent of seniors receive regular cognitive assessments

Few Seniors Receive Regular Brief Cognitive Assessments

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Report also reveals number of seniors living with Alzheimer disease projected to increase
A number of warning/advisory letters have been issued to 17 companies for selling illegal products that claim to prevent

FDA Warns 17 Companies About Illegal Alzheimer Disease Products

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The products are often sold on websites and social media and may be ineffective, unsafe