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Tag: Alzheimer’s

Migraines are a significant risk factor for Alzheimer disease and all-cause dementia

Migraines Linked to Higher Risk for Dementia, Alzheimer Disease

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However, no link seen between migraines and vascular dementia
Most cerebrovascular risk factors are associated with an increased risk for subsequent diagnosis of Parkinson disease

Cerebrovascular Risk Factors May Up Risk for Parkinson Disease

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Most cerebrovascular risk factors linked to higher risk for subsequent diagnosis of Parkinson disease
Plasma β-amyloid (Aβ)42/Aβ40 corresponds with amyloid positron emission tomography status

Plasma Assay Promising for Diagnosis of Early Alzheimer Disease

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Aβ42/Aβ40, age, and APOE ε4 status combination corresponds with amyloid PET with AUC of 0.94
A staging system of β-amyloid accumulation may be useful for monitoring patients throughout the course of Alzheimer disease

Novel PET Staging System May Help Monitor Alzheimer Disease

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Positron emission tomography used to track stages of β-amyloid accumulation in vivo
Greater physical activity and lower vascular risk are associated with slower β-amyloid-related cognitive decline in clinically normal older adults

Physical Activity Linked to Slower Aβ-Related Cognitive Decline

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Exercise, lower vascular risk independently attenuate negative link for Aβ burden, cognitive decline
A first-degree family history of dementia is associated with memory deficits decades before the typical onset of Alzheimer disease

Family History of Dementia Tied to Early Memory Deficits

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Reduced paired-associates learning performance observed long before typical onset of Alzheimer disease
Exposure to anticholinergic drugs is associated with an increased dementia risk

Exposure to Anticholinergics May Increase Dementia Risk

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Risk up for exposure to anticholinergics including antidepressants, antiparkinson drugs, antipsychotics
For patients with mild-to-moderate Alzheimer disease

Nilvadipine Increases Cerebral Blood Flow in the Hippocampus

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CBF did not significantly change in posterior cingulate cortex, other regions of interest in Alzheimer disease
An entorhinal cortex-based virtual reality navigation task can differentiate patients with mild cognitive impairment at low and high risk for developing dementia

Virtual Reality IDs Navigation Issues in Early Alzheimer Disease

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Classification accuracy superior to cognitive tests considered highly sensitive to early disease
Low-density lipoprotein cholesterol is associated with the probability of developing early-onset Alzheimer disease

Higher LDL-C Levels Linked to Early-Onset Alzheimer Disease

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Cases with EOAD have higher levels of LDL-C, greater frequency of rare genetic coding variants of APOB