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Tag: Alzheimer’s

A staging system of β-amyloid accumulation may be useful for monitoring patients throughout the course of Alzheimer disease

Novel PET Staging System May Help Monitor Alzheimer Disease

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Positron emission tomography used to track stages of β-amyloid accumulation in vivo
Greater physical activity and lower vascular risk are associated with slower β-amyloid-related cognitive decline in clinically normal older adults

Physical Activity Linked to Slower Aβ-Related Cognitive Decline

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Exercise, lower vascular risk independently attenuate negative link for Aβ burden, cognitive decline
A first-degree family history of dementia is associated with memory deficits decades before the typical onset of Alzheimer disease

Family History of Dementia Tied to Early Memory Deficits

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Reduced paired-associates learning performance observed long before typical onset of Alzheimer disease
Exposure to anticholinergic drugs is associated with an increased dementia risk

Exposure to Anticholinergics May Increase Dementia Risk

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Risk up for exposure to anticholinergics including antidepressants, antiparkinson drugs, antipsychotics
For patients with mild-to-moderate Alzheimer disease

Nilvadipine Increases Cerebral Blood Flow in the Hippocampus

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CBF did not significantly change in posterior cingulate cortex, other regions of interest in Alzheimer disease
An entorhinal cortex-based virtual reality navigation task can differentiate patients with mild cognitive impairment at low and high risk for developing dementia

Virtual Reality IDs Navigation Issues in Early Alzheimer Disease

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Classification accuracy superior to cognitive tests considered highly sensitive to early disease
Low-density lipoprotein cholesterol is associated with the probability of developing early-onset Alzheimer disease

Higher LDL-C Levels Linked to Early-Onset Alzheimer Disease

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Cases with EOAD have higher levels of LDL-C, greater frequency of rare genetic coding variants of APOB
Community-dwelling patients with Alzheimer disease experience a lower risk for fractures

Thiazide Use May Lower Fracture Risk in Patients With Alzheimer Disease

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Longer thiazide use tied to decreased risk for low-energy fractures, hip fractures in Alzheimer disease
Naproxen sodium twice daily is not associated with reduced progression of presymptomatic Alzheimer disease among cognitively intact people at risk for the condition

Naproxen Sodium Does Not Slow Presymptomatic Alzheimer Disease

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Study shows increased frequency of adverse events but little impact on rate of change in APS
Low scam awareness is associated with an increased risk for Alzheimer disease and mild cognitive impairment among older adults

Low Scam Awareness May Indicate Alzheimer Risk in Seniors

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Increased risk for Alzheimer dementia, mild cognitive impairment seen with low scam awareness in seniors