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Tag: Alzheimer’s

Rural Medicare beneficiaries with Alzheimer disease and related dementia spend more time in nursing homes

Rural Patients With Alzheimer Disease Have Shorter Survival

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Rural versus urban patients also spend more time in nursing homes, receive less home health care
More daytime noise exposure may increase the risk for poorer late-life cognition and risk for dementia

Daytime Noise Tied to Higher Dementia Risk

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More daytime noise tied to 30 percent higher risk for mild cognitive impairment, Alzheimer disease
Patients with type 2 diabetes are more likely to develop vascular dementia and nonvascular dementia compared with controls without diabetes

T2DM Links to Risk for Dementia Differ by Type, Glycemic Control

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Dose-response association shows higher risk for dementia with HbA1c >87 versus <52 mmol/mol
Anticholinergic medications are associated with an increased risk for incident mild cognitive impairment and cognitive decline in older adults

Anticholinergic Meds May Raise Risk for Cognitive Decline

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Effects significantly worse among individuals with risk factors for Alzheimer disease
Alzheimer disease (AD) may causally influence sleep patterns

Relationship Between Alzheimer Disease, Sleep Patterns Explored

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No evidence supporting causal role of disturbed sleep patterns on AD or between major depression and AD
Years of education and the ε4 risk allele at APOE influence β-amyloid pathology in asymptomatic individuals with a parental history of sporadic Alzheimer disease (AD)

Education May Affect β-Amyloid Burden in Alzheimer Disease

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Findings seen in two cohorts with parental history of sporadic AD, autosomal dominant AD
Repetitive negative thinking may be associated with increased Alzheimer disease risk

Long-Term Negative Thinking Tied to Alzheimer Risk

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Association seen between negative thinking, cognitive decline, neuroimaging markers
Plasma tau phosphorylated at threonine 217 shows promise as a biomarker for Alzheimer disease

P-tau217 Shows Promise as Biomarker for Alzheimer Disease

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Plasma P-tau217 discriminated AD from other neurodegenerative diseases in three selected cohorts
Patients with Alzheimer disease have increased iron concentration in the deep gray matter and neocortical regions compared with healthy controls

Brain Iron Concentrations Increased in Alzheimer Disease

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Increased iron concentration seen in deep gray matter, neocortical regions versus healthy controls
Cognitively normal women have increased Alzheimer disease endophenotype

Women Have More Brain Changes Related to Alzheimer Disease

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Menopausal status the predictor most consistently and strongly linked to brain differences, after sex