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Pioglitazone Use Linked to Reduced Dementia Risk in T2DM

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Reduction in risk was greatest for those with history of ischemic heart disease or stroke

Pioglitazone may not be effective for lowering blood glucose levels

Pioglitazone Has Limited Effect in Lipoatrophic Diabetes

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Slight liver function improvement seen in lipoatrophic diabetes induced by juvenile dermatomyositis
For patients after an ischemic stroke or transient ischemic attack

Greater Benefit for Pioglitazone in High-Risk Patients Post Stroke

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Patients at higher risk for stroke or MI derive greater benefit from pioglitazone versus low-risk patients
For patients with long-standing poorly controlled type 2 diabetes mellitus on metformin plus a sulfonylurea

Exenatide, Pioglitazone Effective for Poorly Controlled T2DM

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Findings in patients with long-standing poorly controlled type 2 diabetes on metformin, sulfonylurea
For adults with metabolic syndrome

Pioglitazone Improves Whole-Body Aerobic Capacity in MetS

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Improvements in intramyocellular lipid content, skeletal muscle high-energy phosphate metabolism
For insulin-resistant patients with recent ischemic stroke or transient ischemic attack

Pioglitazone Cuts Diabetes Risk After Ischemic Stroke, TIA

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Findings for patients with recent ischemic stroke/TIA and insulin resistance, but no history of diabetes
For patients with prediabetes or type 2 diabetes mellitus and nonalcoholic steatohepatitis

Long-Term Pioglitazone Safe, Effective for NASH, T2DM

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Safe and effective for patients with prediabetes or type 2 diabetes and nonalcoholic steatohepatitis
Genetic variants in CYP2C8 and SLCO1B1 impact the therapeutic response to rosiglitazone in patients with type 2 diabetes

CYP2C8, SLCO1B1 Variants Impact Response to Rosiglitazone

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Genetic variants have clinical impact on response to rosiglitazone, but not pioglitazone
For patients with type 2 diabetes newly treated with antidiabetic drugs

Pioglitazone Linked to Increased Risk of Bladder Cancer

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Duration- and dose-response associations for pioglitazone; no correlation for rosiglitazone
For patients with insulin resistance with recent stroke or transient ischemic attack

ASA: Pioglitazone After Stroke, TIA Helpful in Insulin Resistance

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Linked to reduction in risk of stroke, myocardial infarction in patients with insulin resistance