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Since initiation of the iPLEDGE program in 2006 to reduce fetal exposure to isotretinoin

Pregnancies in Women Taking Isotretinoin Dropped Since 2006

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Pregnancies reduced in women taking isotretinoin since iPLEDGE initiation in 2006, but exposure persists
For patients with acne

AAD: Isotretinoin Exposure for Acne Not Linked to Depression Risk

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Acne patients with, without isotretinoin exposure had no significant difference in depression frequency
Acne relapses are significantly associated with impaired quality of life as well as productivity loss and absenteeism

Acne Relapses Linked to Lower Quality of Life, Productivity

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Relapse reported to be a significant determinant of productivity loss and absenteeism
Tretinoin 0.05 percent lotion (ALTRENO Lotion) provides statistically significant improvement in patients with moderate-to-severe acne compared with placebo

Clinical Trials Support Efficacy of Tretinoin Lotion for Tx of Acne

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Phase 3 trials show significant improvement compared with placebo for moderate-to-severe acne vulgaris
Acne is associated with increased probability of developing major depressive disorder

Acne Linked to Increased Risk of Major Depressive Disorder

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Significantly increased risk of developing MDD in first five years after diagnosis; highest risk in first year
Microneedling combined with trichloroacetic acid peeling is more effective than microneedling by dermaroller plus platelet-rich plasma or microneedling alone for treatment of acne scarring

Microneedling Plus TCA Peel Performs Well in Acne Scarring

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Combo of microneedling + trichloroacetic acid more effective than microneedling +/- platelet-rich plasma
Long-term oral macrolide administration may increase macrolide-resistant Propionibacterium acnes

Long-Term Macrolide Use Linked to Resistant P. Acnes

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Long-term oral macrolides for treatment of acne may increase macrolide resistance
Acne patients have higher levels of serum homocysteine

Serum Homocysteine Higher in Acne Patients

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Authors say measurement of serum homocysteine may be important for patient management
The combination of sequential 70 percent glycolic acid peel and microneedling results in better acne scar improvement than microneedling alone

Addition of Peel to Microneedling Improves Acne Scar Treatment

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Addition of glycolic acid peel to microneedling linked to better scar improvement, skin texture
Barbers can identify pseudofolliculitis barbae and acne keloidalis nuchae and advise patients on management

Most Barbers Can Identify Pseudofolliculitis Barbae

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Fewer barbers identify acne keloidalis nuchae; most know razor use will aggravate conditions