Pre-op thrombocytosis, leukocytosis tied to post-op morbidity; increased mortality for patients with both
MONDAY, Nov. 16, 2015 (HealthDay News) — For patients with ovarian cancer, preoperative thrombocytosis and leukocytosis are associated with increased postoperative morbidity, according to a study published online Nov. 5 in Obstetrics & Gynecology.
Emma L. Barber, M.D., from the University of North Carolina at Chapel Hill, and colleagues examined the correlation between preoperative thrombocytosis or leukocytosis and postoperative morbidity or mortality in 1,072 patients with ovarian cancer undergoing primary surgery.
The researchers found that 9.6, 18.7, and 4.9 percent of patients had thrombocytosis, leukocytosis, and both, respectively. Both leukocytosis and thrombocytosis were associated with major complications (16.5 versus 10.3 percent [P = 0.01] and 19.4 versus 10.7 percent [P < 0.01], respectively), but not with postoperative death (3.0 versus 1.3 percent [P = 0.08] and 2.9 versus 1.5 percent [P = 0.30], respectively). Increased rates of both major complications and mortality were seen for patients with both thrombocytosis and leukocytosis (22.6 versus 10.9 [P < 0.001] and 5.7 versus 1.4 percent [P = 0.02], respectively). The correlations for leukocytosis and thrombocytosis with major complications persisted after adjustment for age, comorbidities, and surgical complexity (adjusted odds ratios, 1.78 and 2.16, respectively). Thrombocytosis and leukocytosis together correlated with increased risk of postoperative death (adjusted odds ratio, 5.4).
“Preoperative thrombocytosis or leukocytosis is associated with an increased risk of major postoperative complication,” the authors write. “Patients with both thrombocytosis and leukocytosis experienced twice the rate of major complication and a four-fold increase in postoperative death.”
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