Periodontitis may add to systemic inflammation in patients with chronic kidney disease
TUESDAY, Feb. 23, 2016 (HealthDay News) — Periodontitis is associated with increased mortality in patients with chronic kidney disease (CKD), according to research published online Feb. 18 in the Journal of Clinical Periodontology.
Praveen Sharma, of the University of Birmingham in the United Kingdom, and colleagues conducted a survival analysis using data from the Third National Health and Nutrition Examination Survey and linked mortality data. The association between periodontitis and mortality rate in individuals with stage 3 to 5 CKD was assessed. This association was compared with the association between mortality and traditional risk factors for CKD mortality, such as diabetes.
The researchers found that 861 (6 percent) of the 13,784 participants had CKD. For this cohort, the median follow-up was 14.3 years. After adjustment for confounding variables, the 10-year all-cause mortality rate for individuals with CKD was 32 percent for those without periodontitis and 41 percent for those with periodontitis. The 10-year all-cause mortality rate for individuals with CKD was 43 percent for those who also had diabetes.
“There is a strong, association between periodontitis and increased mortality in individuals with CKD,” the authors write. “Sources of chronic systemic inflammation (including periodontitis) may be important contributors to mortality in patients with CKD.”
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