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Patients Mainly Prefer AI as Second Reader for Screening Mammogram

Higher education linked to higher AI acceptance; concern for bias greater in Hispanic, non-Hispanic Black versus White participants

By Elana Gotkine HealthDay Reporter

WEDNESDAY, April 23, 2025 (HealthDay News) — Use of artificial intelligence (AI) as a second reader in screening mammography is accepted by patients, according to a study published online April 18 in Radiology: Imaging Cancer.

B. Bersu Ozcan, M.D., from the University of Texas Southwestern Medical Center in Dallas, and colleagues conducted a prospective study involving 518 patients undergoing mammography screening between February and August 2023 who were offered a 29-question survey. Independent factors associated with participants’ acceptance of AI use were examined.

The researchers found that 76.5 percent of participants reported no or minimal knowledge of AI. Overall, 4.44 percent accepted stand-alone AI interpretation, while 71.0 percent preferred AI to be used as a second reader. Most participants (88.9 percent) requested radiologist review after an AI-reported abnormality, compared with 51.3 percent who requested radiologist recall review by AI. A higher number of participants would undergo diagnostic examination for radiologist recalls versus AI recalls in cases of discrepancy, although the difference was not significant (94.2 versus 92.6 percent). Greater AI acceptance was seen in association with higher education (odds ratio, 2.05). Concern for bias was seen in association with race and was higher in Hispanic and non-Hispanic Black versus non-Hispanic White participants (odds ratios, 3.32 and 4.31, respectively).

“Our results indicate a cautious optimism among participants about the integration of AI in mammogram interpretation,” the authors write.

One author disclosed ties to the publishing and medical device industries and holds a related patent.


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