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BRAF V600 Is Targetable in Some Nonmelanoma Cancers

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Vemurafenib active in NSCLC, Erdheim-Chester disease, Langerhans'-cell histiocytosis
Obesity enhances local myofibroblast content and stiffness-promoting extracellular matrix components in mammary adipose tissue

Obesity May Fuel Breast CA Via Change in Breast Tissue Structure

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Findings suggest obesity can trigger structural changes in extracellular matrix
Two-thirds of acute abdominal aortic aneurysm events occur in those aged ≥75 years

Two-Thirds of Acute AAA Occur in Those Aged 75 Years and Older

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Overall, 96.4 percent of events in men aged younger than 75 years occur in ever smokers
Treatment with a dual wavelength non-ablative fractional laser may result in the functional improvement of scar contractures

Non-Ablative Fractional Laser Could Treat Scar Contracture

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Improvement seen both in appearance and range of motion after treatment
Addyi (flibanserin) has been approved by the U.S. Food and Drug Administration as the first drug to treat generalized hypoactive sexual desire disorder among premenopausal women. The drug is for women who do not have an underlying physical or psychological cause for the disorder

FDA Approves Libido Pill for Women

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Addyi to treat generalized hypoactive sexual desire disorder among premenopausal women
A single nucleotide variant in the FTO obesity locus disrupts a conserved motif

Role of SNP Variant in FTO Explored in Obesity

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Study identifies mechanistic basis for the strongest genetic association with obesity
Trials should be conducted to better establish the cardiovascular safety of testosterone therapy

Heart Safety of Testosterone Unclear for Older Men

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Most men prescribed testosterone have age-related hypogonadism, for which treatment is not approved
The United States should reconsider labeling of genetically modified food

U.S. Should Reconsider Labeling of Genetically Modified Food

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Recommendation made in light of overreliance on herbicide glyphosate, a probable human carcinogen
Evening and morning cortisol levels in older people may be differentially associated with tissue volume in gray and white matter structures and cognitive function

AM, PM Cortisol Tied to Brain, Cognitive Variances in Later Life

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Higher evening salivary cortisol levels tied to lower brain volume, worse cognitive function
Acetaminophen falsely increases continuous glucose monitor glucose values

Acetaminophen Falsely Elevates CGM Glucose Values

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CGM glucose values increased versus blood glucose meter values in acetaminophen challenge