More drugs with high abuse potential made it through the development process than new drugs with low abuse potential
FRIDAY, June 24, 2022 (HealthDay News) — Only one in 10 potential new pain medications make it fully through the drug development process, according to a study published in the June issue of Anesthesiology.
Dermot P. Maher, M.D., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues assessed the probability of successful development and duration of clinical trials for medications to treat neuropathic and nociceptive pain. The analysis used data from the Citeline database (Jan. 1, 2000, to June 30, 2020).
The researchers found that the overall probability of successful development of all pain medications from phase 1 to approval is 10.4 percent. For nociceptive and neuropathic pain treatment, the probability of successful development is 13.3 and 7.1 percent, respectively. For medications with high abuse potential and low abuse potential, the probability of successful development is 27.8 and 4.7 percent, respectively. Between phase 3 and approval is the most common period for attrition. It took an average of 30 months for development of pain medications in large phase 3 safety and efficacy trials.
“The National Institutes of Health and other research sponsors must allocate funding toward the development of safer analgesics and nonpharmacologic pain management strategies,” write the authors of an accompanying editorial.
One author disclosed financial ties to the biomedical, pharmaceutical, and health care analytics industries.
Copyright © 2022 HealthDay. All rights reserved.
