Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for November 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Physicians Report High Rate of Uncontrolled Atopic Dermatitis
THURSDAY, Nov. 30, 2017 (HealthDay News) — Physicians rate a high proportion of patients with atopic dermatitis (AD) as having inadequate disease control, according to a study published online Nov. 13 in the Journal of Dermatology.
Severe Hypoglycemia a Potent Marker of Cardiovascular Risk
THURSDAY, Nov. 30, 2017 (HealthDay News) — Among patients with diabetes, severe hypoglycemia is associated with high absolute risk of cardiovascular events and mortality, according to a study published online Nov. 10 in Diabetes Care.
Incidence of HIV Dropped From 1999 to 2016 in Uganda
THURSDAY, Nov. 30, 2017 (HealthDay News) — The incidence of HIV infection declined significantly in Uganda between 1999 and 2016, according to a study published in the Nov. 30 issue of the New England Journal of Medicine.
Fremanezumab, Erenumab Effective in Treatment of Migraine
THURSDAY, Nov. 30, 2017 (HealthDay News) — Fremanezumab is effective for the prevention of chronic migraine, and erenumab is beneficial for treatment of episodic migraine, according to two studies published in the Nov. 30 issue of the New England Journal of Medicine.
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Abstract/Full Text – Goadsby (subscription or payment may be required)
Editorial (subscription or payment may be required)
Evidence Lacking for Prenatal Vitamin D Supplementation
THURSDAY, Nov. 30, 2017 (HealthDay News) — Prenatal vitamin D supplementation during pregnancy may have some benefits, although the evidence is low quality, according to research published online Nov. 29 in The BMJ.
Mortality Up for Some Cancers in Urban-Dwelling Native Americans
THURSDAY, Nov. 30, 2017 (HealthDay News) — Urban American Indians and Alaskan Natives (AIAN) with cancer have a significantly higher comorbidity burden, and have higher mortality for some cancers, according to a study published online Nov. 29 in Cancer Research.
Mean Serum Allopregnanolone Low Across Weight Extremes
THURSDAY, Nov. 30, 2017 (HealthDay News) — Women at both extremes of the weight spectrum have low mean serum allopregnanolone, which has been linked to increased depression and anxiety severity, according to a study published online Nov. 1 in Neuropsychopharmacology.
Magnesium Boosts Environmental Enrichment in Alzheimer’s
THURSDAY, Nov. 30, 2017 (HealthDay News) — The combination of environmental enrichment (EE) and magnesium-L-threonate (MgT) is more effective than either treatment alone for improving cognition and spatial memory in a mouse model of Alzheimer’s disease (AD), according to a study published online Nov. 10 in CNS Neuroscience & Therapeutics.
Unapproved Drugs Identified in Androgen Receptor Modulators
WEDNESDAY, Nov. 29, 2017 (HealthDay News) — Products marketed as selective androgen receptor modulators and sold via the internet frequently contain unapproved drugs and substances, and the amount of active compound often does not match that listed on the label, according to a study published in the Nov. 28 issue of the Journal of the American Medical Association.
Many Seniors Have Not Discussed Avoiding Drug Interactions
WEDNESDAY, Nov. 29, 2017 (HealthDay News) — Older adults report feeling confident that they know how to avoid drug interactions despite only 35 percent having spoken to someone about it in the past year, according to findings from the National Poll on Healthy Aging, published online Nov. 29.
Endocrine-Disrupting Chemicals Linked to Diabetes Disparities
WEDNESDAY, Nov. 29, 2017 (HealthDay News) — Disparities in exposure to diabetes-associated environmental endocrine-disrupting chemicals (EDCs) may contribute to disparities in diabetes, according to a review published online Nov. 15 in Diabetes Care.
Measuring Plasma PCSK9 May ID Resistance to PCSK9 Inhibitors
TUESDAY, Nov. 28, 2017 (HealthDay News) — Plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) may help assess apparent resistance to PCSK9 inhibitors, according to a research letter published online Nov. 28 in the Annals of Internal Medicine.
CDC: HIV Being Diagnosed Sooner After Infection
TUESDAY, Nov. 28, 2017 (HealthDay News) — HIV is being diagnosed sooner after infection than previously reported, according to a Nov. 28 press release issued by the U.S. Centers for Disease Control and Prevention.
Guidance Issued for Seasonal Allergic Rhinitis Pharmacologic Tx
TUESDAY, Nov. 28, 2017 (HealthDay News) — A workgroup from the Joint Task Force on Practice Parameters has reviewed evidence and provided guidance for health care providers regarding treatment of seasonal allergic rhinitis in patients aged 12 years or older. The clinical guideline was published online Nov. 28 in the Annals of Internal Medicine.
Practice Variation in Treatment for Bronchiolitis in Infants
TUESDAY, Nov. 28, 2017 (HealthDay News) — For infants with bronchiolitis, the use of evidence-based supportive therapies (EBSTs) varies by hospital site, according to a study published online Nov. 28 in Pediatrics.
Similar Efficacy for Intranasal, Intramuscular Naloxone
TUESDAY, Nov. 28, 2017 (HealthDay News) — For reversal of opioid overdose, higher-concentration intranasal naloxone has similar efficacy to that of intramuscular naloxone administered at the same dose, according to a review published online Nov. 27 in the Annals of Internal Medicine.
Considerable Costs Incurred in Response to Single Measles Cases
MONDAY, Nov. 27, 2017 (HealthDay News) — Single measles cases trigger coordinated public health action that is associated with considerable costs, according to research published in the Nov. 24 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.
Anticholinergic Cognitive Burden Scale IDs Adverse Outcomes
MONDAY, Nov. 27, 2017 (HealthDay News) — For older adults, the Anticholinergic Cognitive Burden Scale (ACB) shows good dose-response relationships between anticholinergic burden and adverse outcomes, according to a study published in the November/December issue of the Annals of Family Medicine.
Essay Adds to Discourse on Impact of Suggestive Jokes
MONDAY, Nov. 27, 2017 (HealthDay News) — Seemingly benign, recurring patterns of joking around a single theme (joke cycles) can contribute to humorizing and legitimizing sexual misconduct, according to an essay published online Nov. 12 in Communication and Critical/Cultural Studies.
New Workflows Have Potential to Address Provider Burnout
MONDAY, Nov. 27, 2017 (HealthDay News) — New solutions are needed to address burnout among health care team members, yet, in a catch-22 situation for health industry leaders, change fatigue contributes to burnout, according to a Vocera Communications report entitled In Pursuit of Resilience, Well-Being, and Joy in Healthcare.
Cinnamon Shows Potential As Tool in Fight Against Obesity
MONDAY, Nov. 27, 2017 (HealthDay News) — The compound cinnamaldehyde (CA), found in cinnamon, activates fat cells to start burning energy in both mice and humans, according to a study published in the December issue of Metabolism.
Guidelines Can Cut Nonindicated Acid-Suppressing Rx in Infants
WEDNESDAY, Nov. 22, 2017 (HealthDay News) — Implementation of a guideline can reduce nonindicated use of proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) among newborns, according to a study published online Nov. 21 in Pediatrics.
Immediate Access to Opioid Agonists Found Cost-Effective
WEDNESDAY, Nov. 22, 2017 (HealthDay News) — Immediate access to opioid agonist treatment (OAT) for patients presenting with opioid use disorder may provide greater health benefits at less cost than observed standard of care, according to a study published online Nov. 21 in the Annals of Internal Medicine.
Baby Boomers Have Increased Risk of Rx Opioid Overdose Death
WEDNESDAY, Nov. 22, 2017 (HealthDay News) — Individuals born between 1947 and 1964 have a significantly increased risk of prescription opioid overdose death and heroin overdose death, and those born from 1979 to 1992 also have an increased risk of heroin overdose death, according to a study published online Nov. 21 in the American Journal of Public Health.
Insulin Doesn’t Prevent Diabetes in Relatives of T1DM Patients
TUESDAY, Nov. 21, 2017 (HealthDay News) — Oral insulin does not delay onset of type 1 diabetes in autoantibody-positive relatives of patients with type 1 diabetes, according to a study published in the Nov. 21 issue of the Journal of the American Medical Association.
Intranasal Omalizumab Does Not Increase Serum IgE Levels
TUESDAY, Nov. 21, 2017 (HealthDay News) — In patients with birch pollen allergy, intranasal administration of omalizumab does not result in relevant change of allergen-specific and total immunoglobulin E (IgE) levels, according to a pilot study published online Oct. 30 in Allergy.
Doubts Raised About Use of Products Containing Oxybenzone
TUESDAY, Nov. 21, 2017 (HealthDay News) — Use of oxybenzone (Benzophenone-3) in sunscreen and personal care products should be minimized due to its dermatological and environmental toxicity, according to a review published online Oct. 31 in the Journal of Cosmetic Dermatology.
5-Fluorouracil Promising for Vaginal Intraepithelial Neoplasia
TUESDAY, Nov. 21, 2017 (HealthDay News) — 5-fluorouracil is associated with a 74 percent success rate as the initial treatment modality for high-grade intraepithelial vaginal dysplasia, according to a study published online Nov. 7 in Obstetrics & Gynecology.
Higher β-Blocker Dose Linked to Lower Mortality Risk
TUESDAY, Nov. 21, 2017 (HealthDay News) — An increased β-blocker dose is associated with a greater prognostic advantage in patients with chronic heart failure (CHF) and diabetes than in those with CHF but no diabetes, according to a study published online Oct. 25 in Diabetes Care.
NOACs Show Lower Risk of Adverse Renal Outcomes in A-Fib
TUESDAY, Nov. 21, 2017 (HealthDay News) — For patients with atrial fibrillation (AF), non-vitamin K antagonist oral anticoagulants (NOACs) are associated with lower risks of adverse renal outcomes than warfarin, according to a study published in the Nov. 28 issue of the Journal of the American College of Cardiology.
Brain Glucose Responses Diminish With Diabetes, Obesity
MONDAY, Nov. 20, 2017 (HealthDay News) — The rise of brain glucose levels is blunted during hyperglycemia in adults with obesity and type 2 diabetes mellitus (T2DM), according to a study published online Oct. 19 in JCI Insight.
Dating Violence Victimization, Nonmedical Rx Med Use Linked
MONDAY, Nov. 20, 2017 (HealthDay News) — For male and female high school students, nonmedical use of prescription drugs (NMUPD) is associated with experiences of dating violence victimization (DVV), according to a study published online Nov. 20 in Pediatrics.
SMS Reminders Moderately Effective for Flu Vaccination
MONDAY, Nov. 20, 2017 (HealthDay News) — Short message service (SMS) reminders are a moderately effective way to increase the rate of influenza vaccination among high-risk patients, according to a study published in the November/December issue of the Annals of Family Medicine.
Many Health Care Providers Work While Sick
FRIDAY, Nov. 17, 2017 (HealthDay News) — More than 40 percent of health care personnel (HCP) with influenza-like illness (ILI) work while ill, according to a study published in the November issue of the American Journal of Infection Control.
Simple Checklist Can Identify Useful Clinical Practice Guidelines
FRIDAY, Nov. 17, 2017 (HealthDay News) — A simple, easy-to-use checklist, the Guideline Trustworthiness, Relevance, and Utility Scoring Tool (G-TRUST), can identify useful clinical practice guidelines, according to a study published in the September/October issue of the Annals of Family Medicine.
Intensive BP Control Lacks Benefit in Chronic Kidney Disease
FRIDAY, Nov. 17, 2017 (HealthDay News) — Intensive blood pressure (BP) control may provide no benefit and may even be harmful for patients with moderate-to-advanced chronic kidney disease, according to a study published online Oct. 16 in the Journal of Internal Medicine.
Psychosocial Benefit Seen With Probiotic, Peanut Oral Immunotx
FRIDAY, Nov. 17, 2017 (HealthDay News) — Probiotic and peanut oral immunotherapy (PPOIT) has a sustained beneficial effect on psychosocial impact of food allergy after end-of-treatment, according to a study published online Oct. 20 in Allergy.
Allopurinol Has Little Benefit in Cardiac Syndrome X
FRIDAY, Nov. 17, 2017 (HealthDay News) — Allopurinol does not appear to improve exercise capacity or peripheral endothelial or coronary function in patients with cardiac syndrome X, according to a study published online Oct. 28 in Cardiovascular Therapeutics.
First-Line Metformin Use for DM Up; Sulfonylurea Use Down
FRIDAY, Nov. 17, 2017 (HealthDay News) — Among patients with type 2 diabetes initiating antidiabetes drugs (ADDs), first-line use of metformin has increased since 2005, while sulfonylureas have remained the most popular second-line agent, according to a study published online Nov. 6 in Diabetes Care.
Erlotinib Overdose Tied to Conjunctivitis
FRIDAY, Nov. 17, 2017 (HealthDay News) — Overdosing of erlotinib may be associated with rapid onset of conjunctivitis, according to a case report published online Oct. 25 in the Journal of Clinical Pharmacy and Therapeutics.
FDA OKs Drug for Hemophilia A With Factor VIII Inhibitors
FRIDAY, Nov. 17, 2017 (HealthDay News) — Hemlibra (emicizumab-kxwh) has been approved by the U.S. Food and Drug Administration to prevent or reduce the frequency of bleeding episodes among hemophilia A patients with Factor VIII inhibitors.
Drug Combo Doesn’t Lengthen Glioblastoma Survival
THURSDAY, Nov. 16, 2017 (HealthDay News) — In patients with progressive glioblastoma, treatment with lomustine plus bevacizumab does not confer a survival advantage over treatment with lomustine alone, according to a study published online Nov. 15 in the New England Journal of Medicine.
FDA Investigation Linked to Drop in Codeine Rx for Children
THURSDAY, Nov. 16, 2017 (HealthDay News) — The U.S. Food and Drug Administration (FDA) investigation into the safety of codeine use by children, which culminated in a black box warning in February 2013, led to substantially decreased codeine prescribing to children after tonsillectomy and/or adenoidectomy, according to a study published online Nov. 16 in Pediatrics.
Peer Review Policy Cuts Atypical Antipsychotic Use in Children
THURSDAY, Nov. 16, 2017 (HealthDay News) — For young children, implementation of a peer review prior authorization (PA) policy can reduce the use of atypical antipsychotic (AAP) medications, according to a research letter published online Nov. 15 in JAMA Psychiatry.
HPV Vaccine Tied to Reduced Respiratory Papillomatosis Rate
THURSDAY, Nov. 16, 2017 (HealthDay News) — The incidence of juvenile-onset recurrent respiratory papillomatosis (JORRP) in Australia decreased from 2012 to 2016 after implementation of a quadrivalent human papillomavirus (HPV) vaccination program for females aged 12 to 26 years in 2007-2009, according to a study published online Nov. 9 in The Journal of Infectious Diseases.
FDA Approves Drug With Digital Ingestion Tracking System
WEDNESDAY, Nov. 15, 2017 (HealthDay News) — The first drug in the United States with a digital ingestion tracking system has been approved by the U.S. Food and Drug Administration.
Insurance Underlies Black-White Survival Disparity in CRC
WEDNESDAY, Nov. 15, 2017 (HealthDay News) — Insurance coverage differences account for about half of the disparity in survival rates between black and white patients aged 18 to 64 years with colorectal cancer (CRC), according to a study published online Nov. 14 in Gastroenterology.
In 2007-2014, Glycemic Control Plateaued in Diabetes Patients
WEDNESDAY, Nov. 15, 2017 (HealthDay News) — Despite increases in HbA1c testing and awareness, glycemic control seems to have plateaued among patients with diabetes between 2007 and 2014, according to a research letter published online Nov. 14 in the Journal of the American Medical Association.
Peanut Patch Found Safe, Effective for Treating Allergies
WEDNESDAY, Nov. 15, 2017 (HealthDay News) — A 250-μg peanut patch produces a significant treatment response in peanut-allergic patients treated for a year, according to a study published online Nov. 14 in the Journal of the American Medical Association.
XR Naltrexone, Sublingual BUP-NX Deemed Equally Effective
WEDNESDAY, Nov. 15, 2017 (HealthDay News) — Although initiation of extended-release naltrexone (XR-NTX) may be more difficult, XR-NTX and sublingual buprenorphine-naloxone (BUP-NX) are equally safe and effective once initiated for opioid relapse prevention, according to a study published online Nov. 14 in The Lancet.
Poorer Neuropsychological Test Scores for HIV-Positive
WEDNESDAY, Nov. 15, 2017 (HealthDay News) — HIV-positive individuals treated with combination antiretroviral therapy (cART) have poorer neuropsychological test scores than controls but no significant neuropsychological decline over time, according to a study published online Nov. 13 in JAMA Neurology.
Psychostimulant Use Tied to Placental Complications
WEDNESDAY, Nov. 15, 2017 (HealthDay News) — Psychostimulant use during pregnancy is associated with a small increased relative risk of preeclampsia and preterm birth, according to a study published online Nov. 7 in Obstetrics & Gynecology.
Perioperative Aspirin May Benefit Patients With Prior PCI
TUESDAY, Nov. 14, 2017 (HealthDay News) — For patients with prior percutaneous coronary intervention (PCI), perioperative aspirin seems to be beneficial, according to a study published online Nov. 13 in the Annals of Internal Medicine.
Outcomes for Atrial Fibrillation Similar With Dabigatran, Warfarin
TUESDAY, Nov. 14, 2017 (HealthDay News) — In clinical practice, patients starting dabigatran therapy do not have significantly different rates of ischemic stroke or extracranial hemorrhage than those starting warfarin therapy, though they have lower rates of intracranial bleeding, according to a study published online Nov. 13 in the Annals of Internal Medicine.
Drug Combination Cost-Effective for Cesarean Prophylaxis
TUESDAY, Nov. 14, 2017 (HealthDay News) — The addition of azithromycin to cephalosporin for cesarean delivery infection prophylaxis is cost-effective and leads to better maternal outcomes, according to a study published online Nov. 7 in Obstetrics & Gynecology.
Inhaled Corticosteroids Not Linked to Fracture in Children
TUESDAY, Nov. 14, 2017 (HealthDay News) — Inhaled corticosteroids are not associated with increased odds of fracture in the pediatric asthma population, according to a study published online Nov. 13 in JAMA Pediatrics.
Oral Chemotherapy Parity Laws Offer Some Financial Protection
MONDAY, Nov. 13, 2017 (HealthDay News) — The adoption of state oral chemotherapy parity laws has improved financial protection for many patients, according to a study published online Nov. 9 in JAMA Oncology.
Thrombectomy May Be Best in Stroke Patients With Mismatch
MONDAY, Nov. 13, 2017 (HealthDay News) — For patients with acute stroke who were last well six to 24 hours earlier and who had a mismatch between the severity of the clinical deficit and the infarct volume, thrombectomy plus standard care is associated with better outcomes than standard care alone, according to a study published online Nov. 11 in the New England Journal of Medicine to coincide with the annual meeting of the Society of Vascular and Interventional Neurology, held Nov. 8 to 11 in Boston.
Surgeons Often Prescribing Too Many Opioids After Rhinoplasty
MONDAY, Nov. 13, 2017 (HealthDay News) — Patients use a mean of 8.7 of the initially prescribed 20 to 30 hydrocodone-acetaminophen combination tablets after rhinoplasty, according to a study published online Nov. 9 in JAMA Facial Plastic Surgery.
Prenatal Exposure to ADHD Meds Tied to Neonatal Morbidity
MONDAY, Nov. 13, 2017 (HealthDay News) — Exposure to attention-deficit/hyperactivity disorder (ADHD) medication during pregnancy is associated with increased risk of neonatal morbidity, according to a study published online Nov. 10 in Pediatrics.
Breast Cancer Recurrences Steady After Therapy Cessation
THURSDAY, Nov. 9, 2017 (HealthDay News) — When adjuvant endocrine therapy for estrogen receptor-positive breast cancer is stopped after five years, recurrences occur at a steady rate into the future, according to a meta-analysis published online Nov. 8 in the New England Journal of Medicine.
Patients Use ~Half of Opioids Prescribed After Hysterectomy
THURSDAY, Nov. 9, 2017 (HealthDay News) — Gynecologists prescribe about twice the amount of opioids than patients use after hysterectomy for benign, nonobstetric indications, according to a study published online Nov. 7 in Obstetrics & Gynecology.
Vaccination Coverage High for Children Aged 19 to 35 Months
THURSDAY, Nov. 9, 2017 (HealthDay News) — Vaccination coverage has remained above 90 percent for many vaccinations among young children, and progress is being made toward immunization information systems (IISs) program goals, according to two studies published online Nov. 2 in Morbidity and Mortality Weekly Report.
Abstract/Full Text — Hill
Abstract/Full Text — Murthy
Average Cost of Care in Year After Ovarian Cancer Surgery ~$100K
WEDNESDAY, Nov. 8, 2017 (HealthDay News) — For women with ovarian cancer who underwent both surgery and adjuvant chemotherapy, the average medical expenditures are about $100,000 in the first year after surgery, according to a study published online Nov. 7 in Obstetrics & Gynecology.
Sodium Oxybate Promising for Parkinson’s, Daytime Sleepiness
WEDNESDAY, Nov. 8, 2017 (HealthDay News) — For patients with Parkinson’s disease (PD) and excessive daytime sleepiness (EDS), sodium oxybate seems effective and well-tolerated, according to a study published online Nov. 6 in JAMA Neurology.
Glycosylation Differences in Egg-Adapted Vaccines May Cut Impact
WEDNESDAY, Nov. 8, 2017 (HealthDay News) — Differences in glycosylation between H3N2 egg-adapted vaccines and circulating strains probably reduced vaccine effectiveness during the 2016-2017 influenza season, according to a study published online Nov. 6 in the Proceedings of the National Academy of Sciences.
Delay in Tranexamic Acid Administration Reduces Benefit
WEDNESDAY, Nov. 8, 2017 (HealthDay News) — For patients with acute severe bleeding, any delay in treatment with tranexamic acid is associated with a reduction in the survival benefit, according to a meta-analysis published online Nov. 7 in The Lancet.
Lymphoma Risk Up With Thiopurine, Anti-TNF Tx in IBD
WEDNESDAY, Nov. 8, 2017 (HealthDay News) — For patients with inflammatory bowel disease (IBD), the risk of lymphoma is increased with use of thiopurine monotherapy, anti-tumor necrosis factor (TNF) monotherapy, and combination therapy, according to a study published online Nov. 7 in the Journal of the American Medical Association.
In ER, Combination of Ibuprofen, Acetaminophen Relieves Pain
WEDNESDAY, Nov. 8, 2017 (HealthDay News) — For patients presenting to the emergency department with acute extremity pain, the combination of ibuprofen and acetaminophen does not differ in terms of pain reduction from three different opioid and acetaminophen combination analgesics, according to a study published online Nov. 7 in the Journal of the American Medical Association.
Evidence Scant for Treatment of Cough With the Common Cold
WEDNESDAY, Nov. 8, 2017 (HealthDay News) — There has been little change in the treatment recommendations for cough due to the common cold since publication of guidelines in 2006, according to a review published online Nov. 7 in Chest.
Increases in U.S. Health Spending Tied to Health Service Price
WEDNESDAY, Nov. 8, 2017 (HealthDay News) — Factors including increases in health care service price and intensity are associated with increases in U.S. health care spending from 1996 to 2013, according to a study published online Nov. 7 in the Journal of the American Medical Association.
Zelboraf Approved for Use in Erdheim-Chester Disease
WEDNESDAY, Nov. 8, 2017 (HealthDay News) — Zelboraf (vemurafenib) has been approved by the U.S. Food and Drug Administration as the first drug to treat certain adults patients with Erdheim-Chester disease (ECD).
Cannabidiol Concentration Varies Widely in Online Products
TUESDAY, Nov. 7, 2017 (HealthDay News) — Among cannabidiol (CBD) products sold online, there is a wide range of CBD concentrations, and many products are under- or overlabeled, according to a research letter published online Nov. 7 in the Journal of the American Medical Association.
Warfarin Use Linked to Reduced Incidence of Cancer
TUESDAY, Nov. 7, 2017 (HealthDay News) — For adults older than 50 years, warfarin use is associated with reduced incidence of cancer, according to a study published online Nov. 6 in JAMA Internal Medicine.
Lifestyle Changes Successfully Reduce Incidence of Diabetes
TUESDAY, Nov. 7, 2017 (HealthDay News) — Lifestyle modification (LSM) and medications can reduce the incidence of diabetes in adults at risk, although the effects of medications are short-lived, according to a review published online Nov. 6 in JAMA Internal Medicine.
Sertraline Treatment No Benefit for Depressive Symptoms in CKD
TUESDAY, Nov. 7, 2017 (HealthDay News) — Sertraline treatment does not significantly improve depressive symptoms among patients with non-dialysis-dependent chronic kidney disease (CKD) and major depressive disorder (MDD), according to a study published online Nov. 3 in the Journal of the American Medical Association.
Influenza Vaccines in Pediatric ERs Likely Cost-Effective
TUESDAY, Nov. 7, 2017 (HealthDay News) — Influenza vaccination in the pediatric emergency department (PED) setting appears to be a cost-effective strategy, according to a study published online Nov. 6 in JAMA Pediatrics.
Completion Likely With Self-Administration of TB Treatment
TUESDAY, Nov. 7, 2017 (HealthDay News) — Most people complete treatment for latent tuberculosis (TB) without direct observation, according to a study published online Nov. 6 in the Annals of Internal Medicine.
Novel Method Developed for Estimating Prevalence of Diabetes
MONDAY, Nov. 6, 2017 (HealthDay News) — A novel method has been developed to enhance the prevalence estimates of diabetes and prediabetes, according to a study published online Nov. 2 in Preventing Chronic Diseases.
Drop in Proportion of Neonates With Long IV Therapy for UTI
FRIDAY, Nov. 3, 2017 (HealthDay News) — From 2005 to 2015 there was a decrease in the proportion of infants aged ≤60 days with a urinary tract infection (UTI) who received four or more days of intravenous (IV) antibiotics, according to a study published online Nov. 2 in Pediatrics.
CYP2C19-Genotype Guided Antiplatelet Tx May Be Beneficial
FRIDAY, Nov. 3, 2017 (HealthDay News) — Patients with a CYP2C19 loss-of-function allele have increased risk of major adverse cardiovascular events (MACE) with clopidogrel versus alternative antiplatelet therapy after percutaneous coronary intervention (PCI), according to a study published online Nov. 1 in JACC: Cardiovascular Interventions.
Prescription-Strength Steroids Sold Without Prescription
THURSDAY, Nov. 2, 2017 (HealthDay News) — The ability to purchase a product containing a class 3 topical steroid online, without physician authorization, highlights the dangers of prescription-strength medications being acquired as over-the-counter products, according to a research letter published online Nov. 1 in JAMA Dermatology.
Gene Replacement Tx Beneficial in Spinal Muscular Atrophy
THURSDAY, Nov. 2, 2017 (HealthDay News) — Gene replacement therapy is beneficial in spinal muscular atrophy type 1 (SMA1), and nusinersen is beneficial for infants with spinal muscular atrophy, according to two studies published online Nov. 1 in the New England Journal of Medicine.
Abstract/Full Text (subscription or payment may be required) — Mendell
Abstract/Full Text (subscription or payment may be required) — Finkel
Editorial (subscription or payment may be required)
PARP Inhibitors Promising Beyond BRCA1/2 Altered Tumors
THURSDAY, Nov. 2, 2017 (HealthDay News) — PARP inhibitors demonstrate activity in triple-negative breast cancer (TNBC) tumors without BRCA1/2 mutations, according to a study published online Nov. 1 in Clinical Cancer Research.
ACE Inhibitor, Statin No Benefit for T1DM, High Albumin Excretion
THURSDAY, Nov. 2, 2017 (HealthDay News) — For adolescents with type 1 diabetes and high levels of albumin excretion, neither angiotensin-converting-enzyme (ACE) inhibitors nor statins change the albumin-to-creatinine ratio over time, according to a study published online Nov. 1 in the New England Journal of Medicine.
Driving Impairment Warnings Often Not Given With Rx Meds
THURSDAY, Nov. 2, 2017 (HealthDay News) — Not all prescription drug users report receiving warnings about driving impairment, according to a study published online Nov. 1 in the Journal of Studies on Alcohol and Drugs.
PPI-Gastric Cancer Link Remains After H. Pylori Eradication
WEDNESDAY, Nov. 1, 2017 (HealthDay News) — Long-term proton pump inhibitor (PPI) use is associated with increased risk of gastric cancer (GC) even after Helicobacter pylori (HP) eradication therapy, according to a study published online Oct. 31 in Gut.
Updated Guidelines Released for Ventricular Arrhythmias
WEDNESDAY, Nov. 1, 2017 (HealthDay News) — The American College of Cardiology, the American Heart Association, and the Heart Rhythm Society have released updated guidelines for the management of adults who have ventricular arrhythmias (VAs) or who are at risk for sudden cardiac death (SCD). The guidelines were published online Oct. 30 in the Journal of the American College of Cardiology.
Response to Lenalidomide Often Suboptimal in MDS/MPN-RS-T
WEDNESDAY, Nov. 1, 2017 (HealthDay News) — Lenalidomide produces hematologic responses in myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) with ring sideroblasts (RS) and thrombocytosis (MDS/MPN-RS-T), although these responses are often suboptimal, according to a research letter published online Oct. 25 in the American Journal of Hematology.
Dry Mouth Common Medication Reaction in Older Adults
WEDNESDAY, Nov. 1, 2017 (HealthDay News) — In older adults, medication use is significantly associated with xerostomia and salivary gland dysfunction, according to a review published online Oct. 26 in the Journal of the American Geriatrics Society.
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