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Concurrent RNA and DNA Sequencing Improves Variant Detection

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Overall, 17.1 percent of 545 pathogenic/likely pathogenic splicing variants were dependent on RNA evidence for classification

ASN: eGFR No Different With Sparsentan, Irbesartan in Focal Segmental Glomerulosclerosis

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No difference in eGFR slope with sparsentan versus irbesartan among patients with focal segmental glomerulosclerosis

ASN: Multicomponent Intervention Does Not Increase Steps Toward Kidney Transplant

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Intervention does not significantly increase the rate of completed steps toward receiving a kidney transplant

AHA: Depression, Anxiety Linked to CVD Risk Factors, MACE

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Composite measure of perceived stress associated with atherosclerotic and global cardiovascular disease

AHA: High Cardiovascular Health Linked to Lower Phenotypic Age

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Lower phenotypic age, phenotypic age acceleration seen in association with being in highest versus lowest tertile of 'Life's Essential 8'

Tirzepatide Tied to Substantial Additional Weight Loss After Lifestyle Intervention

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Authors say additional benefits seen for other health-related measures

AI Getting Better at Detecting Skin Cancer

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Software improvements show high sensitivity across skin cancer types, including melanoma

High-Powered Magnet Ingestion Still Sending Children to Hospital

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Some disparities seen in injury, treatment, and outcomes based on neighborhood opportunity scores

Five-Year Outcomes Similar With TAVR, Surgery in Low-Risk Patients

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Similar outcomes seen for patients with severe, symptomatic aortic stenosis at low surgical risk

Landiolol Does Not Reduce Organ Failure in Septic Shock Patients With Tachycardia

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Mean Sequential Organ Failure Assessment score did not differ for those receiving landiolol and standard care