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The incidence of oxybutynin prescription was 27.3 percent among elderly individuals receiving antimuscarinic prescriptions from 2006 to 2012

Oxybutynin Frequently Used for Overactive Bladder in U.S. Elderly

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Despite known adverse effects, including cognitive decline, oxybutynin most frequently prescribed
Magnetic resonance imaging-targeted biopsy could reduce the need for biopsies and overdiagnosis with low-grade prostate cancer

MRI-Based Strategy Reduces Biopsies in Prostate CA Screening

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MRI-based screening could reduce unnecessary biopsies, overdiagnosis of low-grade cancer
Early

Early, Goal-Directed Therapy No Benefit in Septic Shock

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Patient-level meta-analysis shows similar mortality at 90 days for EGDT and usual care
For patients with sepsis requiring mechanical ventilation

DEX Doesn’t Reduce Mortality in Those With Sepsis on Ventilator

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Dexmedetomidine also did not reduce ventilator-free days for sepsis patients on mechanical ventilation
For patients undergoing hemodynamic support after cardiac surgery

No Hemodynamic Benefit With Levosimendan After Cardiac Sx

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No decrease in 30-day mortality for patients undergoing hemodynamic support after cardiac sx
For patients with hypoxemia after cardiac surgery

Intensive Strategy Addresses Hypoxemia After Cardiac Surgery

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Intensive alveolar recruitment strategy linked to less severe pulmonary complications after cardiac sx
For patients with septic shock in U.S. hospitals affected by a 2011 norepinephrine shortage

2011 Norepinephrine Shortage Upped Mortality in Septic Shock

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Patients with septic shock in hospitals affected by drug shortage had increased rate of in-hospital death
Guidelines differ on recommendations for statin treatment in African-Americans

ACC: Guidelines Differ on Statin Eligibility for African-Americans

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More African-Americans at high risk of CV events eligible for statin therapy under ACC/AHA guidelines
Rivaroxaban is associated with reduced risk of recurrent events among patients with venous thromboembolism in equipoise for continued anticoagulation

ACC: Rivaroxaban Beats Aspirin for Lower Risk of Recurrent VTE

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Low dose cuts risk in equipoise for continued anticoagulation; rate of bleeding similar to aspirin
For patients with locally-advanced non-small-cell lung cancer

Raised CTCs Precede Recurrence in Locally-Advanced NSCLC

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Fifteen of 20 patients with recurrence had increase in circulating tumor cell counts post chemoradiation