Genetic, early-life familial environmental factors seem not to contribute to link
THURSDAY, June 6, 2019 (HealthDay News) — Midlife type 2 diabetes is associated with an increased risk for cerebral infarction and cerebral artery occlusion in late life, according to a study published online June 6 in Diabetologia.
Rongrong Yang, from Tianjin Medical University in China, and colleagues examined the role of genetic and early-life familial and environmental factors in the correlation between midlife type 2 diabetes mellitus and cerebrovascular disease (CBD). Data were included for 33,086 twin individuals born in 1958 or earlier, who were free from CBD before age 60.
The researchers found that the odds ratios of type 2 diabetes were 1.29 (95 percent confidence interval [CI], 1.03 to 1.61), 2.03 (95 percent confidence interval, 1.20 to 3.44), 0.52 (95 percent CI, 0.12 to 2.21), and 0.78 (95 percent CI, 0.45 to 1.36) for cerebral infarction, occlusion of cerebral arteries, subarachnoid hemorrhage, and intracerebral hemorrhage, respectively, after adjustment for age, sex, education, body mass index, smoking, alcohol consumption, marital status, hypertension, and heart disease. The odds ratio of the type 2 diabetes-cerebral infarction association was 0.96 (95 percent CI, 0.51 to 1.80) in multi-adjusted regression. From the generalized estimation equation and co-twin control analyses, the differences in odds ratios were not statistically significant (P = 0.780).
“Our findings highlight the need to control midlife type 2 diabetes to help prevent cerebral infarction and occlusion of cerebral arteries in late life,” the authors write.
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