Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for June 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Psychological Risks Higher in Atopic Dermatitis Patients
FRIDAY, June 30, 2017 (HealthDay News) — Depression, anxiety, and suicidal ideation is more common among individuals with atopic dermatitis (AD), according to a study published online June 20 in Allergy.
Poll Finds Seniors Struggling With Drug Costs Don’t Seek Help
FRIDAY, June 30, 2017 (HealthDay News) — Many older Americans who have difficulty paying for their medications don’t seek help in finding more economical options, according to the University of Michigan National Poll on Healthy Aging.
Nivolumab Rx Beyond Progression Beneficial in Melanoma
FRIDAY, June 30, 2017 (HealthDay News) — For select patients with advanced melanoma, nivolumab beyond Response Evaluation Criteria in Solid Tumors v1.1-defined progression is beneficial, according to a study published online June 29 in JAMA Oncology.
T1DM Patients With Active β-Cell Function Differ Immunologically
FRIDAY, June 30, 2017 (HealthDay News) — Patients with remaining endogenous β-cell function after a decade of living with type 1 diabetes tend to have much higher levels of interleukin-35 (IL-35) than other patients with long-standing type 1 diabetes, according to a study published in the June issue of Diabetes Care.
Many Women Have Questions, Concerns About Tamoxifen
FRIDAY, June 30, 2017 (HealthDay News) — Many women at high risk for breast cancer do not take tamoxifen to prevent the disease, often because they confuse naturally occurring symptoms with side effects from the medication, according to a study published online June 29 in the Journal of Clinical Oncology.
EPO Doping Has Little Effect on Real-World Cycling Performance
FRIDAY, June 30, 2017 (HealthDay News) — For well-trained cyclists, erythropoietin improves a laboratory test of maximal exercise, but does not affect submaximal exercise or road race performance, according to a study published online June 29 in The Lancet Haematology.
Dutasteride Associated With Metabolic Safety Concerns
FRIDAY, June 30, 2017 (HealthDay News) — Dutasteride for the treatment of benign prostatic hyperplasia may induce imbalance in metabolic function, according to a study published online June 21 in Hormone Molecular Biology and Clinical Investigation.
Clindamycin, TMP-SMX Linked to Better Outcomes for Abscesses
FRIDAY, June 30, 2017 (HealthDay News) — For small skin abscesses, treatment with clindamycin or trimethoprim-sulfamethoxazole (TMP-SMX) is associated with improved short-term outcomes versus incision and drainage alone, according to a study published online June 28 in the New England Journal of Medicine.
In HIV, Greater BMD Decline for Immediate Versus Delayed ART
FRIDAY, June 30, 2017 (HealthDay News) — Immediate antiretroviral (ART) initiation at HIV diagnosis is associated with greater bone mineral density (BMD) declines compared with deferred initiation, according to a study published online June 26 in the Journal of Bone and Mineral Research.
Health of the Nation Presented in 40th Annual CDC Report
THURSDAY, June 29, 2017 (HealthDay News) — The health of the United States is summarized in the 40th annual report published by the U.S. Centers for Disease Control and Prevention.
Review Links Flaxseed Consumption to Weight Reduction
THURSDAY, June 29, 2017 (HealthDay News) — Whole flaxseed consumption is associated with significant reductions in body weight, body mass index (BMI), and waist circumference, according to a review published online June 21 in Obesity Reviews.
Most Cutaneous Procedures Seem Safe During Isotretinoin Rx
THURSDAY, June 29, 2017 (HealthDay News) — There is insufficient evidence to support delaying several cutaneous surgical procedures in the setting of systemic isotretinoin therapy, although mechanical dermabrasion and fully ablative laser are not recommended, according to a review published online June 28 in JAMA Dermatology.
Metformin Therapeutic As Post-Ischemic Conditioning Agent
THURSDAY, June 29, 2017 (HealthDay News) — Metformin has therapeutic potential as a post-ischemic conditioning agent, according to a study published online June 23 in Cardiovascular Therapeutics.
Brain Stimulation No Better Than Escitalopram for Depression
THURSDAY, June 29, 2017 (HealthDay News) — Escitalopram may outperform transcranial direct-current stimulation (tDCS) in the treatment of depression, according to a study published in the June 29 issue of the New England Journal of Medicine.
Dissolvable Microneedle Patch for Flu Vaccine Found Safe, Effective
WEDNESDAY, June 28, 2017 (HealthDay News) — An experimental flu vaccine patch with dissolving microneedles appears safe and effective, according to research published online June 27 in The Lancet.
Rx Changes, Counseling, Regular Visits Can Cut Opioid Deaths
WEDNESDAY, June 28, 2017 (HealthDay News) — Three simple steps could decrease opioid-related mortality by about a third, according to a report published online June 26 in Drug and Alcohol Dependence.
PPIs Not Found to Raise Risk of Alzheimer’s Disease
WEDNESDAY, June 28, 2017 (HealthDay News) — Proton pump inhibitors (PPIs) don’t appear to increase the risk of dementia, as has been previously suspected, according to a study published online June 7 in the Journal of the American Geriatrics Society.
FDA Seeks to Increase Number of Generic Drugs on Market
WEDNESDAY, June 28, 2017 (HealthDay News) — New measures to increase the number of generic prescription drugs available to Americans have been taken by the U.S. Food and Drug Administration.
Review Questions Antithrombotic Tx in Essential Thrombocythemia
WEDNESDAY, June 28, 2017 (HealthDay News) — For patients with essential thrombocythemia (ET), the evidence relating to risks and benefits of antithrombotic therapy is lacking, according to a review published online June 27 in the Annals of Internal Medicine.
Empagliflozin Ups β Cell Function in Impaired Fasting Glucose
WEDNESDAY, June 28, 2017 (HealthDay News) — Empagliflozin is associated with improved beta cell function in subjects with impaired fasting glucose (IFG), according to a study published online June 13 in Diabetes.
Estimated Prevalence of Diabetes 10.9 Percent in China
TUESDAY, June 27, 2017 (HealthDay News) — The prevalence of diabetes is 10.9 percent in China, but only 36.5 percent of those with diabetes are aware of their diagnosis, according to research published online June 27 in the Journal of the American Medical Association.
Better Outcomes for Cardiology Care in Newly Diagnosed A-Fib
TUESDAY, June 27, 2017 (HealthDay News) — For patients with newly diagnosed atrial fibrillation (AF), cardiology care is associated with improved outcomes versus primary care, according to a study published in the July 4 issue of the Journal of the American College of Cardiology.
Many Adverse Events Related to Cosmetics Go Unreported
TUESDAY, June 27, 2017 (HealthDay News) — Health problems related to cosmetics are underreported, according to a study published online June 26 in JAMA Internal Medicine.
Longer Survival for Midostaurin + Chemotherapy in AML With FLT3
MONDAY, June 26, 2017 (HealthDay News) — For patients with acute myeloid leukemia (AML) and a FLT3 mutation, midostaurin plus chemotherapy is associated with prolonged overall and event-free survival, according to a study published online June 23 in the New England Journal of Medicine.
Review Spotlights Optimal Care of T2DM + Osteoporosis
MONDAY, June 26, 2017 (HealthDay News) — Optimal management of coexisting type 2 diabetes (T2D) and osteoporosis should consider the scientific evidence, according to a review published online June 21 in the Journal of Clinical Endocrinology & Metabolism.
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Review Links Conjugated Linoleic Acid Supplementation to CRP
FRIDAY, June 23, 2017 (HealthDay News) — Conjugated linoleic acid (CLA) supplementation is associated with an increase in serum C-reactive protein (CRP) concentration, according to a review and meta-analysis published online May 29 in Cardiovascular Therapeutics.
Anti-TNF-α Rx Improves Sleep Quality in Ankylosing Spondylitis
FRIDAY, June 23, 2017 (HealthDay News) — Anti-tumor necrosis factor-α (TNF-α) therapy improves sleep quality (SQ) in patients with ankylosing spondylitis (AS) without any improvement in polysomnography (PSG) measures, according to a study published online May 29 in the International Journal of Rheumatic Diseases.
Shared Decision-Making Encouraged in Multiple Sclerosis
FRIDAY, June 23, 2017 (HealthDay News) — Patients should be engaged in decision-making about multiple sclerosis (MS) and the treatment options available, according to a report published online May 29 in Practical Neurology.
Primary Care Pharmacy Model Attractive to Patients
FRIDAY, June 23, 2017 (HealthDay News) — Patients express preference for a pharmacy-driven model of primary care versus a pharmacy offering minimal primary care services, according to a study published online June 18 in the Journal of Clinical Pharmacy and Therapeutics.
Drug, Herb Interactions Frequent for Cancer Patients
FRIDAY, June 23, 2017 (HealthDay News) — Patients with cancer frequently have herb-drug interactions (HDI) and drug-drug interactions (DDI), some of which have clinical consequences, according to research published online June 19 in the Journal of Oncology Practice.
1991-2014 Saw Minimal Change in Health Spending Per State
THURSDAY, June 22, 2017 (HealthDay News) — From 1991 to 2014 there was minimal change in health spending by state, according to a study published online June 14 in Health Affairs.
Opioid Rx Too Often Given to Back Pain Patients With Depression
THURSDAY, June 22, 2017 (HealthDay News) — Patients with low back pain who are depressed are more likely to be prescribed opioids, and to be prescribed higher doses, according to a study published online June 20 in PAIN Reports.
Isotretinoin May Impair Wound Healing After Tattoo
THURSDAY, June 22, 2017 (HealthDay News) — Isotretinoin may impair wound healing after tattooing, according to a case report published online June 16 in the International Journal of Dermatology.
Valproic Acid Concentration Drops With Ketogenic Diet
THURSDAY, June 22, 2017 (HealthDay News) — For patients with epilepsy, anti-epileptic drug serum concentrations remain stable during the ketogenic diet (KD), apart from those of valproic acid, according to a study published online June 18 in the Journal of Clinical Pharmacy and Therapeutics.
Nearly 60 Percent With Conjunctivitis Fill Antibiotic Rx
THURSDAY, June 22, 2017 (HealthDay News) — Antibiotic prescriptions are filled by nearly 60 percent of patients newly diagnosed with acute conjunctivitis, according to a study published online June 14 in Ophthalmology.
Nivolumab Doesn’t Up PFS in Stage IV or Recurrent NSCLC
WEDNESDAY, June 21, 2017 (HealthDay News) — For patients with previously untreated stage IV or recurrent non-small-cell lung cancer (NSCLC), nivolumab is not associated with longer progression-free survival than chemotherapy, according to a study published in the June 22 issue of the New England Journal of Medicine.
Sharp Rise Among Women for Opioid-Related Hospitalizations
WEDNESDAY, June 21, 2017 (HealthDay News) — Opioid-related hospitalizations among women in the United States increased far faster than among men between 2005 and 2014, according to the U.S. Agency for Healthcare Research and Quality (AHRQ).
Early Loop Diuretic Tx Tied to Lower Mortality in Heart Failure
WEDNESDAY, June 21, 2017 (HealthDay News) — For patients with acute heart failure, early treatment with loop diuretics is associated with lower in-hospital mortality, according to a study published online June 19 in the Journal of the American College of Cardiology.
Causes of Serious Adverse Events in Nursing Homes Identified
WEDNESDAY, June 21, 2017 (HealthDay News) — Most serious adverse events in nursing homes are caused by medication errors, falls, delayed or inappropriate interventions, and missed nursing care, according to a study published online June 15 in the Journal of Clinical Nursing.
Strategies Compared for Cancer Medication Submission Lags
WEDNESDAY, June 21, 2017 (HealthDay News) — For development of oncology drugs in Japan, the global trial (GT) strategy and early-initiation bridging (BG) strategy are associated with shorter submission lag (SL) than late-initiation BG strategy, according to a study published online June 19 in the Journal of Clinical Pharmacology.
HCC Drops Beyond Five Years of Entecavir/Tenofovir Tx for Hep B
WEDNESDAY, June 21, 2017 (HealthDay News) — For Caucasian patients with chronic hepatitis B (CHB), the incidence of hepatocellular carcinoma (HCC) decreases beyond year five of entecavir/tenofovir therapy, particularly in those with compensated cirrhosis, according to a study published online June 16 in Hepatology.
Guidelines Address Peri-Op Care in Rheumatic Disease
TUESDAY, June 20, 2017 (HealthDay News) — Guidelines have been developed for perioperative management of antirheumatic drug therapy in patients with rheumatic diseases undergoing elective total hip arthroplasty (THA) or total knee arthroplasty (TKA); the guidelines were published online June 16 in Arthritis Care & Research.
Financial Incentives May Increase Viral Suppression in HIV
TUESDAY, June 20, 2017 (HealthDay News) — For HIV-positive patients, financial incentives can lead to increased viral suppression, according to a study published online June 19 in JAMA Internal Medicine.
More Americans Using High-Doses of Vitamin D Supplementation
TUESDAY, June 20, 2017 (HealthDay News) — Rising numbers of Americans may be getting too much vitamin D via supplementation, according to a research letter published in the June 20 issue of the Journal of the American Medical Association.
Marital Status Among Factors Tied to Gout Rx Adherence
TUESDAY, June 20, 2017 (HealthDay News) — For patients with gout, higher levels of belief about medicines, presence of comorbidity, and being married appear to increase urate-lowering therapy adherence, according to a study published online June 15 in the Journal of Clinical Nursing.
Support for Financial Penalties Up With Emphasis on Patient Harms
TUESDAY, June 20, 2017 (HealthDay News) — Physicians who receive information about patient harms are more likely to support financial penalties targeting inappropriate antibiotic prescribing, according to a research letter published online June 20 in the Annals of Internal Medicine.
NSAID Use, Survival Link Varies With KRAS Status in CRC Patients
TUESDAY, June 20, 2017 (HealthDay News) — Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with improved survival among colorectal cancer (CRC) survivors with KRAS wild-type tumors, according to a study published online June 15 in the Journal of Clinical Oncology.
Tofacitinib Associated With Improvement in Nail Psoriasis
TUESDAY, June 20, 2017 (HealthDay News) — Tofacitinib is associated with improvements in nail psoriasis, according to a study published in the July issue of the Journal of the American Academy of Dermatology.
Risk of Cardiovascular Events Similar With, Without Diabetes
TUESDAY, June 20, 2017 (HealthDay News) — For patients undergoing coronary angiography (CAG), those with and without diabetes without coronary artery disease (CAD) have the same risk of death, cardiac death, and myocardial infarction, according to a study published online June 8 in Diabetes Care.
Acupuncture Found to Be an Effective Analgesia Option in ER
MONDAY, June 19, 2017 (HealthDay News) — Acupuncture is a safe and effective alternative to pain medications for some emergency department patients, according to a study published in the June 19 issue of the Medical Journal of Australia.
Medications Underutilized for Treating Youth Opioid Abuse
MONDAY, June 19, 2017 (HealthDay News) — The rate of opioid addiction among Americans age 25 and under rose nearly six-fold from 2001 to 2014, but few are receiving medical treatment that might prevent overdose or relapse, according to a report published online June 19 in JAMA Pediatrics.
Month of BID Pimecrolimus Best in Facial Seborrheic Dermatitis
MONDAY, June 19, 2017 (HealthDay News) — Pimecrolimus 1 percent cream applied twice a day for four weeks seems to be the best regimen for patients with facial seborrheic dermatitis, according to a study published online June 7 in the Journal of Cosmetic Dermatology.
Chronic Lyme Disease Treatments Tied to Serious Adverse Effects
MONDAY, June 19, 2017 (HealthDay News) — Serious bacterial infections have been documented during treatment for chronic Lyme disease, according to research published in the June 16 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.
VKA Monotherapy Linked to Reduced MI, Stroke Risk in A-Fib
MONDAY, June 19, 2017 (HealthDay News) — For patients with atrial fibrillation (AF), vitamin K antagonist (VKA) monotherapy is associated with reduced risk of first-time myocardial infarction (MI) and stroke compared with acetylsalicylic acid (ASA) monotherapy, according to a study published in the June 20 issue of the Journal of the American College of Cardiology.
Depression Inversely Linked to Body Composition in Teens
MONDAY, June 19, 2017 (HealthDay News) — There is an inverse correlation for major depressive disorder (MDD) severity with measures of body composition among older adolescents, while a positive association is seen for selective serotonin reuptake inhibitors (SSRI), according to a study published online June 16 in Pediatrics.
Opioid Addicts Find It Hard to Avoid Fentanyl
FRIDAY, June 16, 2017 (HealthDay News) — More than half of all drug overdose deaths may be caused by fentanyl, according to two studies published online recently in the International Journal of Drug Policy.
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Health Insurers Recruiting Former Pharma Reps to Cut Costs
FRIDAY, June 16, 2017 (HealthDay News) — Health insurers are recruiting former pharmaceutical company representatives to educate doctors and help save money on prescription medications, according to a report published June 8 in Kaiser Health News.
Case Report: Acneiform Eruption Tied to Vitamin B12 Therapy
FRIDAY, June 16, 2017 (HealthDay News) — In a case report published online June 8 in the Journal of Cosmetic Dermatology, acneiform eruption associated with vitamin B12 therapy is described in five female patients ranging in age from 21 to 62 years.
20 Percent of Hospital Patients Have Side Effects From Abx Rx
FRIDAY, June 16, 2017 (HealthDay News) — About 20 percent of U.S. hospital patients who receive antibiotics experience side effects from the drugs, according to research published online June 12 in JAMA Internal Medicine.
Replacing Saturated Fats With Healthy Fats Lowers CVD Risk
FRIDAY, June 16, 2017 (HealthDay News) — Replacing saturated fats with polyunsaturated fats and monounsaturated fats can reduce cardiovascular disease risk as much as statins, according to a new American Heart Association (AHA) advisory published online June 15 in Circulation.
Text Messaging Intervention Can Up Glycemic Control in T2DM
FRIDAY, June 16, 2017 (HealthDay News) — For low-income Hispanic patients with poorly controlled type 2 diabetes, a text messaging intervention can improve glycemic control, according to a study published online June 9 in Diabetes Care.
AMA Endeavors to Increase Transparency of Rx Pricing
THURSDAY, June 15, 2017 (HealthDay News) — The American Medical Association (AMA) is calling for more transparency in drug pricing amid rising costs that are putting some lifesaving medications out of reach for patients and communities.
Economic Burden of Neonatal Abstinence Syndrome Up Sharply
THURSDAY, June 15, 2017 (HealthDay News) — Rates of neonatal abstinence syndrome (NAS) have risen dramatically in recent years — and so has the cost of treating it, according to a study published online June 14 in Addiction.
High HCV Cure Rates in HIV Coinfection Cases at Urban Clinic
THURSDAY, June 15, 2017 (HealthDay News) — For patients in an urban clinic with hepatitis C virus (HCV) with HIV coinfection, HCV treatment is effective with standardized nurse/pharmacist support, according to a study published online June 13 in Hepatology.
Strategies Implemented to Cut Opioid ODs, Deaths in Maryland
THURSDAY, June 15, 2017 (HealthDay News) — Strategies are being implemented to reduce opioid overdoses and deaths in Maryland, according to a report published by the American Medical Association (AMA).
Concentrated Broccoli Sprout Extract May Help Fight T2DM
THURSDAY, June 15, 2017 (HealthDay News) — Sulforaphane, found in cruciferous vegetables such as broccoli, may help obese type 2 diabetes patients better regulate dysglycemia, according to a study published in the June 14 issue of Science Translational Medicine.
Good Results for Zone MPC-Based Artificial Pancreas
THURSDAY, June 15, 2017 (HealthDay News) — A zone model predictive control (MPC)-based artificial pancreas (AP) system improves glycemic control in a home-use environment, according to a study published online June 5 in Diabetes Care.
Antiplatelet Bleeding Risk Higher Than Expected for Older Patients
WEDNESDAY, June 14, 2017 (HealthDay News) — Long-term daily aspirin use is linked to a higher-than-expected risk of disabling or fatal bleeding in patients aged 75 and over, according to a study published online June 13 in The Lancet.
Amphotericin Tops Itraconazole in HIV-Linked Talaromycosis
WEDNESDAY, June 14, 2017 (HealthDay News) — For patients with HIV with talaromycosis, amphotericin B deoxycholate (amphotericin) is superior to itraconazole, according to a study published in the June 15 issue of the New England Journal of Medicine.
Factors Predictive of Parental Intent to Vaccinate Against HPV
WEDNESDAY, June 14, 2017 (HealthDay News) — Maternal education, Hispanic ethnicity, and provider recommendations are associated with parental intent to vaccinate adolescents against human papillomavirus (HPV), according to a study published in the June 8 issue of the U.S. Centers for Disease Control and Prevention’s Preventing Chronic Disease.
Metformin Tied to Decreased BMI z Score in Prepubertal Children
WEDNESDAY, June 14, 2017 (HealthDay News) — In prepubertal, but not pubertal, obese children, metformin is associated with decreased body mass index (BMI) z score and improved inflammatory and cardiovascular-related obesity parameters, according to a study published online June 12 in Pediatrics.
Glycation of Hemoglobin Differs by Race
WEDNESDAY, June 14, 2017 (HealthDay News) — Both biological and socioeconomic factors appear to play a role in higher hemoglobin A1c (HbA1c) readings seen in black patients with diabetes, according to research published online June 13 in the Annals of Internal Medicine.
Value of Prolonged DAPT Varies With DAPT Score in PCI Patients
WEDNESDAY, June 14, 2017 (HealthDay News) — For patients undergoing percutaneous coronary intervention (PCI), prolonged dual-antiplatelet therapy (DAPT) results in harm for those with low DAPT scores but reduces risk for ischemic events for those with high scores receiving paclitaxel-eluting stents, according to a study published online June 13 in the Annals of Internal Medicine.
FeSO4 May Be Best Iron Choice in Pediatric Iron-Deficiency Anemia
WEDNESDAY, June 14, 2017 (HealthDay News) — For children with nutritional iron-deficiency anemia (IDA), ferrous sulfate is associated with a greater increase in hemoglobin concentration at 12 weeks compared with iron polysaccharide complex, according to a study published in the June 13 issue of the Journal of the American Medical Association.
Inpatient Clinicians Show Limited Understanding of PCN Allergy
WEDNESDAY, June 14, 2017 (HealthDay News) — Inpatient hospital practitioners often have a limited understanding of the management of patients with a history of penicillin allergy, according to a study published online June 13 in the Annals of Allergy, Asthma & Immunology.
Expedited Partner Therapy Helps Reduce STI Incidence
TUESDAY, June 13, 2017 (HealthDay News) — States that let doctors prescribe drugs to treat chlamydia or gonorrhea in both partners when only one makes an office visit have lower rates of the sexually transmitted infections, according to a study published online May 17 in Sexually Transmitted Infections.
Olive Oil, Ibuprofen May Have Synergistic Effects
TUESDAY, June 13, 2017 (HealthDay News) — The combination of extra virgin olive oil (EVOO) and ibuprofen at a therapeutic dose is superior to the two compounds used separately, according to an experimental study published online June 7 in the International Journal of Rheumatic Diseases.
Beta-Blockers Cut Mortality for Patients in Sinus Rhythm
TUESDAY, June 13, 2017 (HealthDay News) — For patients with heart failure with reduced ejection fraction in sinus rhythm, beta-blockers reduce mortality regardless of pre-treatment heart rate, according to a study published in the June 20 issue of the Journal of the American College of Cardiology.
Traditional Chinese Medicine May Benefit Some CVD Patients
MONDAY, June 12, 2017 (HealthDay News) — Traditional Chinese medicine (TCM) might have a role to play in treating or preventing cardiovascular disease in the West, according to a review published in the June 20 issue of the Journal of the American College of Cardiology.
Lumacaftor, Ivacaftor Linked to Improved Lung Function in CF
MONDAY, June 12, 2017 (HealthDay News) — For patients aged 6 to 11 years with cystic fibrosis homozygous for F508del-cystic fibrosis transmembrane conductance regulator (CFTR), lumacaftor and ivacaftor treatment is associated with significant improvement in lung function, according to a study published online June 9 in The Lancet Respiratory Medicine.
CDC: Kidney Disease Affects One in Seven Americans
MONDAY, June 12, 2017 (HealthDay News) — Thirty million American adults (one in seven) have chronic kidney disease — but many don’t know it, according to an analysis of data from the U.S. Centers for Disease Control and Prevention.
Vitamin B6 Linked to Increased Risk of Hip Fracture
MONDAY, June 12, 2017 (HealthDay News) — Vitamin B6, but not vitamin B12, is associated with increased risk of hip fracture during extended follow-up, according to a study published online June 2 in the Journal of Bone and Mineral Research.
Birth Control Pills Recalled Due to Danger of Unintended Pregnancy
FRIDAY, June 9, 2017 (HealthDay News) — One lot of Mibelas 24 Fe birth control pills has been recalled due to a packaging error that could put users at risk of unintended pregnancy, according to manufacturer Lupin Pharmaceuticals.
Opioids Tend to Be Over-Prescribed After Cesarean Section
FRIDAY, June 9, 2017 (HealthDay News) — Women are routinely prescribed more opioid medications than they need after cesarean sections, creating a high risk for misuse, according to three studies published in the July issue of Obstetrics & Gynecology.
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FDA Approves Generic Version of HIV Drug Truvada
FRIDAY, June 9, 2017 (HealthDay News) — The first generic version of the HIV drug Truvada (emtricitabine and tenofovir disoproxil fumarate) has been approved by the U.S. Food and Drug Administration.
FDA Requests Removal of Opana ER From Market
FRIDAY, June 9, 2017 (HealthDay News) — Sales of reformulated Opana ER should be halted in the United States, the U.S. Food and Drug Administration says.
Sitagliptin Stimulates Distal Tubular Natriuresis in T2DM
FRIDAY, June 9, 2017 (HealthDay News) — For patients with type 2 diabetes, the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin stimulates distal tubular natriuresis, according to a study published online May 26 in Diabetes Care.
Young CA Survivors More Often Have Cost-Related Nonadherence
FRIDAY, June 9, 2017 (HealthDay News) — Survivors of adolescent and young adult cancer are more likely to report cost-related medication nonadherence, according to a study published online May 23 in Cancer.
Relapse Down With Clozapine, Injectables in Schizophrenia
FRIDAY, June 9, 2017 (HealthDay News) — For patients with schizophrenia, clozapine and long-acting injectable antipsychotic medications are associated with the lowest risk of psychiatric rehospitalization, according to a study published online June 7 in JAMA Psychiatry.
Omalizumab Protects Against Early, Late Allergic Responses
THURSDAY, June 8, 2017 (HealthDay News) — For patients with a significant response to allergen challenge, omalizumab induces protective effects against early (EAR) and late allergic reactions (LAR), according to a study published online June 5 in Allergy.
U.S. Leads in Income-Based Health Care Inequalities
THURSDAY, June 8, 2017 (HealthDay News) — The United States has larger income-related differences in perceptions of health and health care than other middle- and high-income countries, according to a report published in the June issue of Health Affairs.
Lithium’s Risk to Fetus May Be Lower Than Previously Thought
THURSDAY, June 8, 2017 (HealthDay News) — Lithium is linked to an increased risk of heart malformations in infants born to women taking the drug during pregnancy, but the risk is smaller than once believed, according to research published in the June 8 issue of the New England Journal of Medicine.
Researchers Target Zolmitriptan Dosing for Pediatric Migraine
THURSDAY, June 8, 2017 (HealthDay News) — In a report published online June 5 in the Journal of Clinical Pharmacology, recommended dosing regimens of zolmitriptan are suggested for children with migraine.
Antidepressants in Pregnancy Don’t Affect Newborn Behavior
THURSDAY, June 8, 2017 (HealthDay News) — Use of antidepressants in pregnancy is not associated with increased signs of irritability, difficulty feeding, sleep disturbances, or respiratory problems in infants two to four weeks after birth, according to a study published in the May issue of the Journal of Clinical Psychiatry.
SGLT2 Inhibitors Linked to Increased Risk of Ketoacidosis
THURSDAY, June 8, 2017 (HealthDay News) — Sodium-glucose cotransporter 2 (SGLT2) inhibitors appear to increase the risk of diabetic ketoacidosis in patients with type 2 diabetes, according to a research letter published in the June 8 issue of the New England Journal of Medicine.
CDC: High-Deductible Health Plan Use Rising Among Employers
WEDNESDAY, June 7, 2017 (HealthDay News) — High-deductible health plans are becoming more common among U.S. adults with employer-sponsored health insurance coverage, according to a report issued June 6 by the U.S. Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS).
Many Bariatric Surgery Patients Using Opioids Seven Years Later
WEDNESDAY, June 7, 2017 (HealthDay News) — About 20 percent of U.S. bariatric surgery patients are still using prescription opioids seven years later, according to a study published recently in Surgery for Obesity and Related Diseases.
Severe Hypoglycemia Rates Have Equilibrated for DCCT Groups
WEDNESDAY, June 7, 2017 (HealthDay News) — Rates of severe hypoglycemia have equilibrated between the two Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) treatment groups in association with duration of diabetes and HbA1c level, according to a study published online May 26 in Diabetes Care.
Combo of Several Meds at Smaller Doses May Boost HTN Care
TUESDAY, June 6, 2017 (HealthDay News) — Combining low doses of several different antihypertensive medications may be better than using a standard dose of just one drug, according to a review published online June 5 in Hypertension.
Many Taking NOACs for A-Fib May Not Be Getting Right Dose
TUESDAY, June 6, 2017 (HealthDay News) — Nearly one in six Americans taking non-vitamin K antagonist oral anticoagulants for atrial fibrillation may not be receiving the proper dose, according to a study published in the June 13 issue of the Journal of the American College of Cardiology.
Venlafaxine Use Linked to Bone Turnover Markers in Older Adults
TUESDAY, June 6, 2017 (HealthDay News) — Depression treatment with venlafaxine is associated with increased levels of the bone resorption marker C-terminal cross-linking telopeptide of type 1 collagen (CTX), as well as decreased levels of the bone formation marker procollagen type 1 N-propeptide (P1NP), according to a study published online May 26 in the Journal of the American Geriatrics Society.
Prevalence of Advanced HIV at ART Initiation Decreasing
TUESDAY, June 6, 2017 (HealthDay News) — From 2004 to 2015 there were decreases in the prevalence of advanced disease at initiation of antiretroviral therapy (ART) in 10 high-burden countries, according to research published in the June 2 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.
Positive Clinical Effects Seen for Placebos Without Deception
TUESDAY, June 6, 2017 (HealthDay News) — Open-label placebos are associated with a positive effect compared with no treatment in a variety of clinical conditions, according to a review and meta-analysis published online May 30 in the Journal of Evidence-Based Medicine.
Lower HbA1c Linked to Better Diabetes-Specific HRQoL in Youth
TUESDAY, June 6, 2017 (HealthDay News) — For children, teens, and young adults with type 1 diabetes mellitus (T1DM), hemoglobin A1c (HbA1c) is associated with better diabetes-specific health-related quality of life (D-HRQoL), according to a study published online May 25 in Diabetes Care.
Grass Pollen SLIT Slows Course of Allergic Rhinitis, Asthma
MONDAY, June 5, 2017 (HealthDay News) — For patients with allergic rhinitis (AR), sublingual immunotherapy (SLIT) is associated with slower AR progression and less frequent asthma onset, according to research published online May 31 in Allergy.
2011 to 2014 Saw Increase in Use of High-Intensity Statins After MI
FRIDAY, June 2, 2017 (HealthDay News) — From 2011 to 2014 there was an increase in the use of high-intensity statins following hospitalization for myocardial infarction (MI), according to a study published in the June 6 issue of the Journal of the American College of Cardiology.
MTHFR A1298C Polymorphism Not Linked to MTX Outcomes in RA
FRIDAY, June 2, 2017 (HealthDay News) — The methylene tetrahydrofolate reductase (MTHFR) gene A1298C polymorphism does not appear to be related to methotrexate (MTX) efficacy or toxicity in patients with rheumatoid arthritis (RA), according to a meta-analysis published online May 25 in the International Journal of Rheumatic Diseases.
Short-Term Benefits for Immunotherapy in Allergic Asthma
FRIDAY, June 2, 2017 (HealthDay News) — Administration of allergen immunotherapy (AIT) in patients with allergic asthma leads to lower short-term symptom and medication scores, according to a review published online May 19 in Allergy.
Cool Water Works As Well As Hot for Ridding Hands of Germs
FRIDAY, June 2, 2017 (HealthDay News) — For effective hand hygiene, water temperature matters less than time, according to a study published in the June issue of the Journal of Food Protection.
Reducing SBP Targets Below Current Guidelines Cuts Risk
FRIDAY, June 2, 2017 (HealthDay News) — For adults with hypertension treated with antihypertensive medication, reducing systolic blood pressure (SBP) levels to 120 to 124 mm Hg is associated with reduced risk of cardiovascular disease and all-cause mortality, according to a review published online May 31 in JAMA Cardiology.
Model Predicts Acute GI Bleeding in Anticoagulated Patients
FRIDAY, June 2, 2017 (HealthDay News) — For patients taking oral anticoagulants, a new model can predict acute gastrointestinal (GI) bleeding, which is associated with increased risk of all-cause mortality, according to a study published online May 19 in the Journal of Gastroenterology and Hepatology.
Substantial Increase in Costs With Metastases in Prostate CA
FRIDAY, June 2, 2017 (HealthDay News) — Diagnosis of subsequent metastases is associated with substantially increased costs and medical resource use (MRU) among patients initially diagnosed with localized prostate cancer (PC), according to a study published online May 23 in Cancer.
Excess Weight Increases Costs Across Health Care Settings
THURSDAY, June 1, 2017 (HealthDay News) — Excess weight is associated with increased costs across health care settings, with the highest percentage increases seen in costs for medications, according to research published online May 22 in Obesity Reviews.
Medication Adherence Up With Refill Synchronization Model
THURSDAY, June 1, 2017 (HealthDay News) — An appointment-based model (ABM) which synchronizes medication refills to improve medication adherence is associated with improvement in medication-taking behavior, according to a review published online May 8 in the Journal of Clinical Pharmacy and Therapeutics.
β-Blocker Use Not Linked to Reduced Mortality After AMI
THURSDAY, June 1, 2017 (HealthDay News) — β-blocker use is not associated with reduced mortality after acute myocardial infarction (AMI) without heart failure or left ventricular systolic dysfunction (LVSD), according to a study published in the June 6 issue of the Journal of the American College of Cardiology.
Certain Breast CA Patients Benefit From Adjuvant Capecitabine
THURSDAY, June 1, 2017 (HealthDay News) — Capecitabine (Xeloda) can extend the lives of patients with human epidermal growth factor receptor 2 (HER2)-negative breast cancer who have residual invasive disease after receipt of neoadjuvant chemotherapy, according to a study published in the June 1 issue of the New England Journal of Medicine.
Three-Drug Combo Pill Nearly 100 Percent Effective in Curing Hep C
THURSDAY, June 1, 2017 (HealthDay News) — A pill containing the antiviral drugs sofosbuvir, velpatasvir, and voxilaprevir is nearly 100 percent effective in curing hepatitis C in patients whose disease returned after treatment with direct-acting antiviral agents, according to research published in the June 1 issue of the New England Journal of Medicine.
Risk of Conversion to Multiple Sclerosis Down With Minocycline
THURSDAY, June 1, 2017 (HealthDay News) — For patients with a first demyelinating event (clinically isolated syndrome), treatment with minocycline is associated with reduced risk of conversion to multiple sclerosis over six months, according to a study published in the June 1 issue of the New England Journal of Medicine.
Antiretroviral Regimen Adherence Up for Americans With HIV
THURSDAY, June 1, 2017 (HealthDay News) — More Americans with HIV are adhering to antiretroviral therapy regimens, according to a study published online May 16 in AIDS.
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