Here are what the editors at HealthDay consider to be the most important developments in Pathology for July 2020. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of July 27 to 31, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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Plenty of COVID-19 Vaccine Coming, Fauci Says
FRIDAY, July 31, 2020 (HealthDay News) — When a COVID-19 vaccine is approved, there should be plenty of it available, Anthony Fauci, M.D., infectious diseases chief at the U.S. National Institutes of Health, told a House panel Friday, the Associated Press reported.
AP News Article
Johns Hopkins University
COVID-19 Testing Needed Every Two Days to Reopen Colleges
FRIDAY, July 31, 2020 (HealthDay News) — Symptom-based screening alone is not sufficient to contain a COVID-19 outbreak on college campuses, according to a study published online July 31 in JAMA Network Open.
Global Epidemiology of COVID-19 Reported for Prepandemic Era
FRIDAY, July 31, 2020 (HealthDay News) — Many of the first COVID-19 cases reported from affected countries outside of mainland China involved recent travel to affected countries, according to a study published online July 29 in The Lancet Infectious Diseases.
Sex Differences in Income Vary With Proportion of Male Doctors
FRIDAY, July 31, 2020 (HealthDay News) — For surgical and nonsurgical specialists, sex differences in income vary with the proportion of male physicians in a practice, according to a study published online July 30 in The BMJ.
School Closures Linked to Decreased COVID-19 Incidence, Death
THURSDAY, July 30, 2020 (HealthDay News) — School closures in the United States were temporally associated with decreased COVID-19 incidence and mortality, according to a study published online July 29 in the Journal of the American Medical Association.
Young Children Have Higher Amounts of SARS-CoV-2 RNA
THURSDAY, July 30, 2020 (HealthDay News) — Young children with mild-to-moderate COVID-19 have higher amounts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA in their nasopharynx than older children and adults, according to a research letter published online July 30 in JAMA Pediatrics.
ACS Issues Updated Guideline for Cervical Cancer Screening
THURSDAY, July 30, 2020 (HealthDay News) — In a guideline update from the American Cancer Society, published online July 30 in CA: A Cancer Journal for Clinicians, recommendations are presented for cervical cancer screening of individuals at average risk.
Most Gynecologic Cancer Therapy Not Tied to Higher COVID-19 Risk
THURSDAY, July 30, 2020 (HealthDay News) — For gynecologic oncology patients with COVID-19, the case fatality rate is 14.0 percent, and chemotherapy and recent major surgery do not predict COVID-19 severity or mortality, according to a study published online July 30 in Cancer.
Depression, Anxiety May Be Signs That COVID-19 Is Attacking Brain
WEDNESDAY, July 29, 2020 (HealthDay News) — Depression and anxiety exhibited in COVID-19 patients may be a sign that the virus impacts the central nervous system, as these symptoms are closely associated with a loss of smell and taste rather than more severe manifestations of the virus, according to a study published online July 2 in The Laryngoscope.
Burden of Pre-, Postmenopausal Breast Cancer Up Worldwide
TUESDAY, July 28, 2020 (HealthDay News) — There is evidence of an increasing burden of premenopausal and postmenopausal breast cancer worldwide, according to a study published in the August issue of The Lancet Global Health.
Myocardial Injury Seen in Many Early in Recovery From COVID-19
TUESDAY, July 28, 2020 (HealthDay News) — Many patients recently recovered from COVID-19 infection have cardiac involvement, according to a study published online July 27 in JAMA Cardiology.
Indigenous American Ancestry Tied to HER2+ Breast Cancer
TUESDAY, July 28, 2020 (HealthDay News) — Indigenous American (IA) origin could partly contribute to the higher incidence of human epidermal growth factor receptor 2-positive (HER2+) breast cancer in Latinas, according to a study recently published in Cancer Research.
Postmarketing Surveillance Helps Identify Vaccine Safety Issues
TUESDAY, July 28, 2020 (HealthDay News) — A review of all safety-related labeling changes for FDA-approved vaccines during a 20-year period shows vaccines are largely safe, and many of the safety issues are identified through postmarketing surveillance, according to a study published online July 28 in the Annals of Internal Medicine.
COVID-19 Vaccine Candidate Now in Final Phase Testing
MONDAY, July 27, 2020 (HealthDay News) — A vaccine developed by the U.S. National Institutes of Health and Moderna has entered the final phase of testing, the Associated Press reported Monday.
AP News Article
Large Proportion of COVID-19 Studies Have Low-Level Evidence
MONDAY, July 27, 2020 (HealthDay News) — A large proportion of studies on COVID-19 have a low level of evidence, according to a research letter published online July 27 in JAMA Internal Medicine.
Higher Prepregnancy Serum Creatinine Linked to Preterm Birth
MONDAY, July 27, 2020 (HealthDay News) — Increased levels of prepregnancy serum creatinine are associated with an increased risk for preterm birth, according to a study published in the July 27 issue of CMAJ, the journal of the Canadian Medical Association.
Metabolomics Screening Tool May Detect Autism Spectrum Disorder
MONDAY, July 27, 2020 (HealthDay News) — A metabolomics screening tool may detect more than 50 percent of individuals with autism spectrum disorder (ASD), according to a study published online June 18 in Autism Research.
Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of July 20 to 24, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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Midnasal Swab Done by Patient at Home Detects SARS-CoV-2
FRIDAY, July 24, 2020 (HealthDay News) — For detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in symptomatic patients, unsupervised home midnasal swab collection is comparable to clinician-collected nasopharyngeal swab collection, according to a research letter published online July 22 in JAMA Network Open.
CDC Guidance Issued for Testing, Management of HCP Exposed to Hep C
FRIDAY, July 24, 2020 (HealthDay News) — In a U.S. Centers for Disease Control and Prevention guidance report, published in the July 24 issue of Morbidity and Mortality Weekly Report, recommendations are presented for testing and clinical management of health care personnel (HCP) exposed to the hepatitis C virus (HCV).
Chimpanzee Adenovirus-Vectored Vaccine Promising for COVID-19
FRIDAY, July 24, 2020 (HealthDay News) — A chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19) expressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein has acceptable safety and induces antibody and T-cell immune responses, according to a study published online July 20 in The Lancet.
Financial Health of Hospitals ‘Dire’ Due to COVID-19
THURSDAY, July 23, 2020 (HealthDay News) — COVID-19 continues to cause financial peril for U.S. hospitals, according to a report released by the American Hospital Association (AHA).
New Guidelines Released for Recovering COVID-19 Patients to Leave Isolation
THURSDAY, July 23, 2020 (HealthDay News) — Many recovering COVID-19 patients in the United States will now be able to leave isolation without further testing to show they are virus-free, the U.S. Centers for Disease Control and Prevention said Wednesday.
The New York Times Article
Most Individuals in U.S. Have Not Been Infected With SARS-CoV-2
THURSDAY, July 23, 2020 (HealthDay News) — During March to early May 2020, most individuals in the United States had not been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), although the estimated number of infections seems to have been much higher than the number of reported cases, according to a study published online July 21 in JAMA Internal Medicine.
Ad5-Vectored COVID-19 Vaccine Immunogenic in Healthy Adults
THURSDAY, July 23, 2020 (HealthDay News) — The nonreplicating adenovirus type-5 (Ad5)-vectored COVID-19 vaccine appears safe and induces immune responses at a dose of 5×1010 viral particles, according to a study published online July 20 in The Lancet.
No Spike Seen in Cases of Polio-Like Condition in Children
WEDNESDAY, July 22, 2020 (HealthDay News) — It is not clear if acute flaccid myelitis (AFM) will follow its usual pattern and if we will see a spike of cases in 2020, the U.S. Centers for Disease Control and Prevention says.
Routine Hepatitis C Testing at FQHCs Would Be Cost-Effective
WEDNESDAY, July 22, 2020 (HealthDay News) — Routine hepatitis C virus (HCV) testing at federally qualified health centers (FQHCs) would be cost-effective and could improve outcomes for people with HCV infections, according to a study published online June 27 in The American Journal of Medicine.
Predictors of Amyloid-β Deposits Identified in Oldest Old
WEDNESDAY, July 22, 2020 (HealthDay News) — Predictors of amyloid-β (Aβ) deposition have been identified in the oldest old, according to a study published online July 22 in Neurology.
Epidemiology of Herpes Simplex Virus in Europe Transitioning
WEDNESDAY, July 22, 2020 (HealthDay News) — The epidemiology of herpes simplex virus (HSV)-1 is transitioning away from oral acquisition in childhood with an increasing proportion of HSV-1 detection in genital herpes, according to a study published online July 16 in BMJ Global Health.
11.8 Percent of Household Contacts of Index Patients Have COVID-19
TUESDAY, July 21, 2020 (HealthDay News) — Overall, 11.8 percent of household contacts of index COVID-19 patients in South Korea have COVID-19 compared with 1.9 percent of nonhousehold contacts, according to a study published online July 16 in Emerging Infectious Diseases, a publication of the U.S. Centers for Disease Control and Prevention.
Assessing Symptoms, Blood, Stool Markers Best for Identifying Pediatric IBD
TUESDAY, July 21, 2020 (HealthDay News) — For pediatric patients with nonbloody diarrhea, evaluating symptoms plus blood and stool markers is the optimal test strategy for predicting inflammatory bowel disease (IBD), according to a study published online July 21 in Pediatrics.
Blood Test Can Detect Cancer Before Conventional Diagnosis
TUESDAY, July 21, 2020 (HealthDay News) — A noninvasive blood test based on circulating tumor DNA methylation can detect cancer four years before conventional diagnosis, according to a study published online July 21 in Nature Communications.
Blood Type Not Linked to Progression to Severe COVID-19
TUESDAY, July 21, 2020 (HealthDay News) — For COVID-19 patients, blood type is not associated with the risk for progression to severe disease, according to a study published online July 12 in the Annals of Hematology.
Pooled Sampling Approved for COVID-19 Test
MONDAY, July 20, 2020 (HealthDay News) — An emergency use authorization (EUA) has been issued for the Quest Diagnostics Quest SARS-CoV-2 real-time reverse transcription polymerase chain reaction test for use with pooled samples containing up to four individual swab specimens collected under observation, the U.S. Food and Drug Administration said Saturday.
Surgical Delay Worsens Survival for Some Gastrointestinal Cancers
MONDAY, July 20, 2020 (HealthDay News) — Surgical delay is associated with an increased risk in some gastrointestinal malignancies, and understanding the impact on outcomes may assist surgeons in triaging patients whose surgeries were delayed due to the COVID-19 pandemic, according to research published online June 30 in the Journal of Gastrointestinal Surgery.
Reducing Testing Delay Crucial for Slowing COVID-19 Transmission
MONDAY, July 20, 2020 (HealthDay News) — Minimizing testing delay has the largest impact on reducing onward transmission of COVID-19, according to a study published online July 16 in The Lancet Public Health.
Reminder + FIT Test Cost-Effective for Promoting CRC Screening
MONDAY, July 20, 2020 (HealthDay News) — Sending a mailed reminder to promote colorectal cancer (CRC) screening with an included fecal immunochemical testing (FIT) kit is cost-saving for each additional Medicaid enrollee screened compared with just sending a reminder, according to a study published online July 20 in Cancer.
Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of July 13 to 17, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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Call for ‘Challenge Trials’ to Hasten COVID-19 Vaccine Development
FRIDAY, July 17, 2020 (HealthDay News) — The U.S. government should make immediate preparations for clinical trials in which volunteers are exposed to the new coronavirus to speed development of a vaccine, more than 100 top scientists say in a letter to the U.S. National Institutes of Health.
CNN Article
Higher SARS-CoV-2 Viral Load Tied to Shorter Symptom Duration
THURSDAY, July 16, 2020 (HealthDay News) — Viral load (VL) of severe acute respiratory syndrome coronavirus 2 is lower in hospitalized patients, and higher VL is associated with a shorter duration of symptoms and hospital stay, according to a study published online July 2 in The American Journal of Pathology.
U.S. Must Spend $75 Billion to Improve COVID-19 Testing, Report Says
THURSDAY, July 16, 2020 (HealthDay News) — The United States faces “an impending disaster” from the coronavirus pandemic and should spend $75 billion to improve its diagnostic testing system for COVID-19, a Rockefeller Foundation report says.
SARS-CoV-2 mRNA-1273 Induces Immune Response
THURSDAY, July 16, 2020 (HealthDay News) — The candidate vaccine mRNA-1273, which encodes the stabilized prefusion severe acute respiratory syndrome coronavirus 2 spike protein, induces immune responses in healthy participants, according to a phase 1 study published online July 14 in the New England Journal of Medicine.
PRIME Cells ID’d in Blood Before Flare in Rheumatoid Arthritis
THURSDAY, July 16, 2020 (HealthDay News) — Distinct RNA signatures are evident in peripheral blood of rheumatoid arthritis patients before a disease flare, according to a study published in the July 16 issue of the New England Journal of Medicine.
Physical Distancing Interventions Cut Incidence of COVID-19
THURSDAY, July 16, 2020 (HealthDay News) — Physical distancing interventions are associated with a reduced incidence of COVID-19 globally, according to a study published online July 15 in The BMJ.
COVID-19 Vaccine Initiative May Favor Rich Countries
WEDNESDAY, July 15, 2020 (HealthDay News) — A global COVID-19 vaccine initiative has been formed with the objective of ensuring fair distribution of vaccines worldwide, but it may benefit rich countries more than poor nations.
AP News Article
n3-PUFAs May Protect the Brain From Effects of Air Pollution
WEDNESDAY, July 15, 2020 (HealthDay News) — Long-chain omega 3 polyunsaturated fatty acids (LCn3PUFAs) attenuate the inverse association between fine particular matter (PM2.5) exposure and white matter volumes, according to a study published online July 15 in Neurology.
Cardiac CT Can Derive Thoracic Bone Mineral Density, Fracture Risk
WEDNESDAY, July 15, 2020 (HealthDay News) — Cardiac computed tomography (CT) can identify individuals with low bone mineral density (BMD) and increased fracture risk, according to a study published online July 14 in Radiology.
Lymphocytopenia May Predict Greater Severity in COVID-19
WEDNESDAY, July 15, 2020 (HealthDay News) — Lymphocytopenia may be predictive of disease severity in patients with COVID-19, according to a study published online July 10 in the International Journal of Laboratory Hematology.
Global Population Anticipated to Peak in 2064
WEDNESDAY, July 15, 2020 (HealthDay News) — The global population is anticipated to peak in 2064 and then decline to year 2100, according to a study published online July 14 in The Lancet.
Layoffs Cost 5.4 Million Americans Their Health Insurance
TUESDAY, July 14, 2020 (HealthDay News) — About 5.4 million Americans lost their health insurance after being laid off between February and May due to the COVID-19 pandemic, a new study shows.
The New York Times Article
Symptom-Based Testing Not Adequate for Detecting COVID-19
TUESDAY, July 14, 2020 (HealthDay News) — Using symptom-based testing alone is not adequate for identifying COVID-19 cases in long-term care facilities, according to a research letter published online July 14 in JAMA Internal Medicine.
Pap/HPV Cotesting Better for Cervical Cancer Screening in Over 30s
TUESDAY, July 14, 2020 (HealthDay News) — Liquid-based cytology (LBC) and human papillomavirus (HPV) cotesting enhances screening for cervical cancer (CxCa) and precancer among women aged 30 years and older, according to a study published online July 8 in the American Journal of Clinical Pathology.
Genomic Alterations Distinct for Black Men With Prostate Cancer
TUESDAY, July 14, 2020 (HealthDay News) — African-American (AFR) men with prostate cancer have distinct genomic alterations from European-American (EUR) men, according to a study published online July 10 in Clinical Cancer Research.
Rise Seen in U.S. COVID-19 Deaths
MONDAY, July 13, 2020 (HealthDay News) — Led by states in the South and West, COVID-19 deaths in the United States have started a long-anticipated increase, data show.
AP News Article
Slow Test Results Hampering U.S. Fight Against COVID-19
MONDAY, July 13, 2020 (HealthDay News) — Test results for the new coronavirus are taking so long that they are doing little to help stop the spread of the virus in the United States, experts say.
Washington Post Article
Predicted Albumin-Creatinine Ratio Useful for CKD Screening
MONDAY, July 13, 2020 (HealthDay News) — Predicted albumin-creatinine ratio (ACR) calculated from urine protein-creatinine ratio (PCR) or urine dipstick protein may be useful for chronic kidney disease (CKD) screening, staging, and prognosis, according to research published online July 14 in the Annals of Internal Medicine.
S. aureus Agr Virulence Tied to Atopic Dermatitis in Infants
MONDAY, July 13, 2020 (HealthDay News) — Skin colonization by Staphylococcus aureus is associated with the risk for developing atopic dermatitis (AD), and infants who do not develop AD primarily exhibit acquisition of dysfunctional mutations in the S. aureus quorum-sensing system, according to a study published in the July 8 issue of Science Translational Medicine.
Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of July 6 to 10, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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WHO to Lead Investigation of COVID-19 Pandemic Origins
FRIDAY, July 10, 2020 (HealthDay News) — The World Health Organization will lead an international investigation into the origins of the COVID-19 pandemic in China.
AP News Article
The New York Times Article
Children Seem Not to Be Driving SARS-COV-2 Transmission
FRIDAY, July 10, 2020 (HealthDay News) — Children are mainly infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in familial clusters, suggesting that transmission in schools is likely to be less than expected and that school closures are not necessary, according to a study and accompanying editorial published online July 10 in Pediatrics.
Incidence of Takotsubo Cardiomyopathy Up During COVID-19
FRIDAY, July 10, 2020 (HealthDay News) — The incidence of Takotsubo cardiomyopathy has increased during the COVID-19 pandemic, according to a study published online July 9 in JAMA Network Open.
Viral Exposure Signature Predicts Hepatocellular Carcinoma
FRIDAY, July 10, 2020 (HealthDay News) — A viral exposure signature can predict hepatocellular carcinoma (HCC) risk before clinical diagnosis among at-risk patients, according to a study published online June 10 in Cell.
Electronic Health Records Fail to Detect Many Medication Errors
THURSDAY, July 9, 2020 (HealthDay News) — There is wide variation in the safety performance of electronic health record (EHR) systems used in U.S. hospitals, according to a study recently published in JAMA Network Open.
Serum Neurofilament Light May Help Assess Concussion, TBI
THURSDAY, July 9, 2020 (HealthDay News) — Serum neurofilament light (NfL) may be a biomarker for acute and repetitive sports-related concussion and traumatic brain injury (TBI), according to a study published online July 8 in Neurology.
Spectrum of Neurological Disorders Linked to SARS-CoV-2
THURSDAY, July 9, 2020 (HealthDay News) — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a spectrum of neurological disorders, according to a study published online July 8 in Brain.
Huntington Disease Brain Changes ID’d 24 Years Before Symptoms
WEDNESDAY, July 8, 2020 (HealthDay News) — The earliest brain changes due to Huntington disease (HD) can be detected in cerebrospinal fluid (CSF) 24 years before clinical symptoms show, according to a study published in the June 1 issue of The Lancet Neurology.
Long-Acting Drug Targeting Capsid Protein Promising for HIV
WEDNESDAY, July 8, 2020 (HealthDay News) — A small molecule that disrupts the functions of the HIV capsid protein, GS-6207, demonstrates a reduction in plasma viral load and shows sustained plasma exposure, according to a study published online July 1 in Nature.
Company Gets $1.6 Billion From U.S. Government for COVID-19 Vaccine
TUESDAY, July 7, 2020 (HealthDay News) — Vaccine maker Novavax will receive $1.6 billion from the U.S. government to provide 100 million doses of a COVID-19 vaccine by early 2021, the Maryland-based company said Monday.
The New York Times Article
COVID-19 Antibody Cocktail Begins Late-Stage Human Trials
TUESDAY, July 7, 2020 (HealthDay News) — Late-stage human trials to assess whether a double antibody cocktail can prevent and treat COVID-19 infection have started, biotechnology company Regeneron said Monday.
CNN Article
Social Distancing Effective for Mitigating COVID-19 Spread
TUESDAY, July 7, 2020 (HealthDay News) — Social distancing is one of the main measures to combat COVID-19 spread, according to a study published online July 1 in The Lancet Infectious Diseases.
Genetic Variant Identified for Adult-Onset Hearing Loss
TUESDAY, July 7, 2020 (HealthDay News) — An inherited form of adult-onset hearing loss is relatively common, according to a study published online July 6 in the Journal of Medical Genetics.
Fight Against COVID-19 Threatens Progress Against Other Diseases
MONDAY, July 6, 2020 (HealthDay News) — Decades of progress against HIV, tuberculosis, malaria, and other diseases worldwide are threatened by the diversion of resources on the COVID-19 pandemic, the International AIDS Society says in a report to be published this week.
CNN Article
Scientists Say New Coronavirus Can Linger in Indoor Air
MONDAY, July 6, 2020 (HealthDay News) — The new coronavirus can linger in indoor air and infect people, 239 scientists in 32 countries say in an open letter to the World Health Organization that challenges the WHO’s position on how the virus is spread.
The New York Times Article
Medicaid Expansion Contributing to Earlier Cancer Diagnosis
MONDAY, July 6, 2020 (HealthDay News) — Among low-income adults, the odds of being diagnosed with metastatic breast, cervical, colorectal, or lung cancers decreased following Medicaid expansion in Ohio, according to a study published online July 6 in Cancer.
Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of June 29 to July 3, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.
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Evidence Poor for Accuracy of Serological Tests for COVID-19
THURSDAY, July 2, 2020 (HealthDay News) — Existing evidence on the diagnostic accuracy of serological tests for COVID-19 is characterized by high risks of bias and heterogeneity, according to a review and meta-analysis published online July 1 in The BMJ.
Promising Results for Experimental COVID-19 Vaccine in Early Testing
WEDNESDAY, July 1, 2020 (HealthDay News) — An experimental COVID-19 vaccine yielded promising results in early testing, according to Pfizer and its German partner BioNTech.
AP News Article
Model Estimates Herd Immunity Threshold for COVID-19
WEDNESDAY, July 1, 2020 (HealthDay News) — A mathematical model shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease-induced herd immunity level may be lower than the classical model assuming homogenous immunization, according to a report published online June 23 in Science.
Genetic Tests May Differ in Their Interpretation of Certain Variants
WEDNESDAY, July 1, 2020 (HealthDay News) — Different genetic test interpretations have been identified for genetic variants, and some of these can impact patient management, according to a research letter published online June 30 in the Annals of Internal Medicine.
Artificial Intelligence Provides Benefit for Cervical Cancer Screening
WEDNESDAY, July 1, 2020 (HealthDay News) — For women undergoing human papillomavirus (HPV)-based cervical cancer screening, automated evaluation of p16/Ki-67 dual-stained (DS) slides reduces the number of colposcopies compared with current standards, according to a study published online June 25 in the Journal of the National Cancer Institute.
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