Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for January 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
In Situ Vaccine Uses Immune Response to Treat Cancer
WEDNESDAY, Jan. 31, 2018 (HealthDay News) — In situ vaccination is an approach that can trigger an immune response in a manner that is specific to the tumor antigens to treat malignancy, according to a study published online Jan. 31 in Science Translational Medicine.
Tisagenlecleucel Beneficial for Youth With Refractory B-Cell ALL
WEDNESDAY, Jan. 31, 2018 (HealthDay News) — A single infusion of the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, tisagenlecleucel, provides durable remission in pediatric and young adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL), according to a study published in the Feb. 1 issue of the New England Journal of Medicine.
Glecaprevir-Pibrentasvir Effective Treatment for HCV Genotypes 1, 3
WEDNESDAY, Jan. 31, 2018 (HealthDay News) — Once-daily treatment with glecaprevir-pibrentasvir appears safe and effective for the treatment of hepatitis C virus (HCV) genotype 1 or 3, according to a study published in the Jan. 25 issue of the New England Journal of Medicine.
Top Three Challenges Identified for Pharmacists in 2018
TUESDAY, Jan. 30, 2018 (HealthDay News) — The top pharmacy challenges for 2018 are drug affordability, nonadherence, and pharmacist compensation, according to a report published online Jan. 7 in Managed Healthcare Executive.
Statin, BP Lowering Meds Don’t Impact Erectile Function
TUESDAY, Jan. 30, 2018 (HealthDay News) — For older men with at least one cardiovascular risk factor, treatment with statin and/or pharmacologic blood pressure reduction does not significantly impact erectile function, according to a study published in the January issue of the Canadian Journal of Cardiology.
Glucagon Underutilized in Prehospital, Emergency Settings
TUESDAY, Jan. 30, 2018 (HealthDay News) — Glucagon is being underutilized in the prehospital and outpatient setting, according to a research letter published recently in the Annals of Internal Medicine.
Regulators Trying to Reduce Physician Burden Linked to EHR
MONDAY, Jan. 29, 2018 (HealthDay News) — The Office of the National Coordinator for Health Information Technology (ONC) is trying to address some of the issues relating to physician electronic health record (EHR) burden, partly with the appointment of Don Rucker, M.D., who is skilled in informatics and board-certified in emergency and internal medicine, according to an article published in Medical Economics.
Pharmacist Education May Cut Junior Doctor Prescription Errors
MONDAY, Jan. 29, 2018 (HealthDay News) — Pharmacist feedback and education is effective at reducing prescription writing errors by junior doctors in an inpatient setting, according to a study published online Jan. 24 in the Journal of Pharmacy Practice and Research.
Health Care Spending Up, Mainly Due to Rising Prices
MONDAY, Jan. 29, 2018 (HealthDay News) — Americans under age 65 years who were insured through their employer spent more than ever before on health care in 2016, with faster spending growth in 2016 than in recent years, according to the Health Care Cost Institute (HCCI)’s annual Health Care Cost and Utilization Report.
FDA Approves Lutathera for Some Gastro and Pancreatic Cancers
FRIDAY, Jan. 26, 2018 (HealthDay News) — Lutathera (lutetium Lu 177 dotatate) is the first radioactive drug to be approved by the U.S. Food and Drug Administration to treat somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), the agency said Friday in a news release.
Solanezumab Doesn’t Affect Cognitive Decline in Alzheimer’s
FRIDAY, Jan. 26, 2018 (HealthDay News) — For patients with mild Alzheimer’s disease, solanezumab administered every four weeks does not alter cognitive decline, according to a study published in the Jan. 25 issue of the New England Journal of Medicine.
Biomarkers Help Identify CHF Patients Needing Med Titration
THURSDAY, Jan. 25, 2018 (HealthDay News) — Using biomarkers to identify heart failure patients for up-titration of medications may improve mortality and hospitalization rates, according to a study published in the Jan. 30 issue of the Journal of the American College of Cardiology.
Cannabidiol Efficacious for Lennox-Gastaut Drop Seizures
THURSDAY, Jan. 25, 2018 (HealthDay News) — For patients with drop seizures associated with Lennox-Gastaut syndrome, add-on cannabidiol is associated with a reduction in monthly drop seizure frequency, according to a study published online Jan. 24 in The Lancet.
Adjunct Zonisamide Beneficial in Dementia With Lewy Bodies
WEDNESDAY, Jan. 24, 2018 (HealthDay News) — For patients with dementia with Lewy bodies (DLB), zonisamide as an adjunct to levodopa therapy improves parkinsonism, according to a study published online Jan. 24 in Neurology.
Prescribing of Opioids Adds to Patient Satisfaction With Care
WEDNESDAY, Jan. 24, 2018 (HealthDay News) — Patients with musculoskeletal conditions who are using prescribed opioids are more likely to be highly satisfied with their care, according to a study published in the January/February issue of the Annals of Family Medicine.
Anti-Thyroid Rx Exposure Ups Risk of Congenital Malformations
TUESDAY, Jan. 23, 2018 (HealthDay News) — Exposure to anti-thyroid drugs (ATDs) during the first trimester of pregnancy is associated with increased risk of congenital malformations, according to a study published online Jan. 23 in the Annals of Internal Medicine.
Available Evidence on Marijuana’s Cardiovascular Effects Is Scant
TUESDAY, Jan. 23, 2018 (HealthDay News) — The evidence examining associations between marijuana use and cardiovascular risk factors and outcomes is limited, according to a review published online Jan. 23 in the Annals of Internal Medicine.
Out-of-Pocket Expenditures Down With ACA Implementation
TUESDAY, Jan. 23, 2018 (HealthDay News) — Implementation of the Affordable Care Act (ACA) was associated with reduced out-of-pocket spending, although increases were noted in mean premium spending, according to a study published online Jan. 22 in JAMA Internal Medicine.
New ACC/AHA Recs Developed for BP Evaluation, Management
MONDAY, Jan. 22, 2018 (HealthDay News) — New recommendations have been developed for the prevention, detection, evaluation, and management of high blood pressure (BP). The recommendations are summarized in an article published online Jan. 23 in the Annals of Internal Medicine.
Walmart Launches Disposal Solution for Opioids, Rx Meds
MONDAY, Jan. 22, 2018 (HealthDay News) — Walmart is launching a first-of-its-kind opioid disposal solution in all company pharmacies, which is available at no cost, according to a press release from the company.
ADHD Meds Increasingly Prescribed to Reproductive-Aged Women
MONDAY, Jan. 22, 2018 (HealthDay News) — Reproductive-aged women are increasingly being prescribed attention-deficit/hyperactivity disorder (ADHD) medications, according to research published in the Aug. 25 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.
Confusion Common in Seniors Prescribed Antibiotics for UTI
MONDAY, Jan. 22, 2018 (HealthDay News) — Urinary tract infections (UTIs) are common in nursing home (NH) residents, and new or worsening confusion is strongly associated with antibiotic treatment for suspected UTI, according to a study published online Jan. 10 in the Journal of the American Geriatrics Society.
Greater Prior Authorization Requirements Seen for PCSK9i Rx
MONDAY, Jan. 22, 2018 (HealthDay News) — Prior authorization (PA) requirements are greater for proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9is) than for other cardiometabolic drugs, according to a study published online Jan. 11 in Circulation: Cardiovascular Quality and Outcomes.
Anticoagulation Guidance Issued for Cardiopulmonary Bypass
MONDAY, Jan. 22, 2018 (HealthDay News) — Clinical practice guidelines for anticoagulation therapy for cardiopulmonary bypass (CPB) have been developed and were published in the February issue of the Annals of Thoracic Surgery.
Brochure Can Improve Opioid Disposal Rates After Surgery
FRIDAY, Jan. 19, 2018 (HealthDay News) — Disseminating an educational brochure improves disposal of unused opioids after surgery, according to a study published online Jan. 10 in the Journal of the American College of Surgeons.
LDL-C Still High in Autosomal Recessive Hypercholesterolemia
FRIDAY, Jan. 19, 2018 (HealthDay News) — For patients with autosomal recessive hypercholesterolemia (ARH), low-density lipoprotein cholesterol (LDL-C) levels remain high despite intensive treatment, according to a study published in the Jan. 23 issue of the Journal of the American College of Cardiology.
Reminder, Recall Systems Improve Immunization Uptake
FRIDAY, Jan. 19, 2018 (HealthDay News) — Patient reminder and recall systems seem to be effective for improving receipt of immunizations, according to a review published online Jan. 18 in the Cochrane Library.
Pharmacist Participation in Stroke Response Cuts Door➜Needle Time
FRIDAY, Jan. 19, 2018 (HealthDay News) — Having a pharmacist at bedside during acute ischemic stroke is associated with significantly shorter door-to-needle (DTN) times, according to a study published recently in the Annals of Pharmacotherapy.
Longer Duration of Post-Op Opioid Use Associated With Misuse
THURSDAY, Jan. 18, 2018 (HealthDay News) — Each refill and week of opioid prescription following surgery is associated with an increasing risk of opioid misuse among opioid naive patients, according to a study published online Jan. 17 in The BMJ.
Onabotulinum Toxin-A Can Safely Improve Sleep Bruxism
THURSDAY, Jan. 18, 2018 (HealthDay News) — Onabotulinum toxin-A (BoNT-A) injections can improve sleep bruxism, according to a study published online Jan. 17 in Neurology.
Increased Risk of Complications With Bariatric Surgery
THURSDAY, Jan. 18, 2018 (HealthDay News) — Bariatric surgery is associated with lower risks of obesity-related comorbidities but a clinically important increased risk for complications compared with medical treatment, according to a study published in the Jan. 16 issue of the Journal of the American Medical Association, a theme issue on obesity.
Value of Doxylamine-Pyridoxine Questioned in Early Pregnancy
THURSDAY, Jan. 18, 2018 (HealthDay News) — Doxylamine-pyridoxine may be beneficial for nausea and vomiting symptoms in early pregnancy, but the magnitude of the difference is very small and may indicate no clinically important benefit, according to a study published online Jan. 17 in PLOS ONE.
Sulfonamides, Nitrofurantoin Being Given for UTI in Pregnancy
WEDNESDAY, Jan. 17, 2018 (HealthDay News) — For women with urinary tract infections (UTIs), the most frequently prescribed antibiotics during the first trimester are nitrofurantoin, ciprofloxacin, cephalexin, and trimethoprim-sulfamethoxazole, according to research published in the Jan. 12 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.
Psoriasis Remission Described After Hepatitis C Virus Treatment
WEDNESDAY, Jan. 17, 2018 (HealthDay News) — A case of remission of psoriasis after treatment of chronic hepatitis C virus (HCV) has been described in a research letter published online Jan. 16 in the Annals of Internal Medicine.
High Response of Desmoplastic Melanomas to PD-1 Blockade
WEDNESDAY, Jan. 17, 2018 (HealthDay News) — Patients with desmoplastic melanoma have a high level of objective tumor response to treatment with antibodies to block programmed cell death 1 (PD-1) or PD-1 ligand (PD-L1), according to a study published online Jan. 10 in Nature.
Color-Coded Drug Storage Trays May Cut Medication Errors
TUESDAY, Jan. 16, 2018 (HealthDay News) — Color-coded compartmentalized “rainbow trays” used for anesthetic drug preparation and storage may improve patient safety, according to a study published online Jan. 3 in Anaesthesia.
FDA OKs Lynparza to Treat Breast Cancer With BRCA Mutation
FRIDAY, Jan. 12, 2018 (HealthDay News) — Lynparza (olaparib) has been approved by the U.S. Food and Drug Administration to treat metastatic breast cancer caused by a BRCA gene mutation.
Ceramide-Infused Skin Barrier Cuts Stoma-Related Costs
FRIDAY, Jan. 12, 2018 (HealthDay News) — Use of a ceramide-infused ostomy skin barrier is associated with reduced stoma-related cost of care, according to a study published in the January/February issue of the Journal of Wound, Ostomy and Continence Nursing.
Considerable Economic Burden for Asthma in United States
FRIDAY, Jan. 12, 2018 (HealthDay News) — Asthma places a considerable economic burden on the United States, with a total cost of $81.9 billion in 2013, according to a study published online Jan. 12 in the Annals of the American Thoracic Society.
Tamper-Resistant Oxycodone Misused Less Often in Australia
FRIDAY, Jan. 12, 2018 (HealthDay News) — The tamper-resistant formulation of controlled-release oxycodone in Australia reduced tampering among high-risk populations, according to a study published online Jan. 10 in The Lancet Psychiatry.
Treatment of Urgency Urinary Incontinence Aids Sleep Quality
FRIDAY, Jan. 12, 2018 (HealthDay News) — Pharmacologic treatment of urgency urinary incontinence (UUI) improves sleep quality, according to research published online Jan. 9 in Obstetrics & Gynecology.
Progress in Fighting Antibiotic Resistance Shown in CDC Map
THURSDAY, Jan. 11, 2018 (HealthDay News) — The U.S. Centers for Disease Control and Prevention has released new data in its Antibiotic Resistance Investment Map, which shows states’ progress in combating antibiotic resistance.
Prenatal PPI, H2 Blocker Use Linked to Asthma Risk in Child
THURSDAY, Jan. 11, 2018 (HealthDay News) — Prenatal, maternal, acid-suppressive drug use is associated with an increased risk of childhood asthma, according to a review published online Jan. 11 in Pediatrics.
Race, Education Level Predict CRT in Very Elderly With NSCLC
THURSDAY, Jan. 11, 2018 (HealthDay News) — In patients aged 80 and older with advanced non-small-cell lung cancer (NSCLC), overall survival is improved with concurrent chemoradiation therapy (CRT), but black race and lower-educated census tract are associated with not receiving care, according to a study published online Jan. 8 in Cancer.
Acetaminophen Use in Pregnancy Linked to Language Delay
THURSDAY, Jan. 11, 2018 (HealthDay News) — Acetaminophen (acetyl-para-aminophenol [APAP]) use in pregnancy is associated with language delay among girls, according to a study published online Jan. 10 in European Psychiatry.
Neurodevelopment Not Impacted by Glucocorticoids in Preemies
WEDNESDAY, Jan. 10, 2018 (HealthDay News) — Use of inhaled glucocorticoids in extremely preterm infants for the prevention of bronchopulmonary dysplasia does not lead to a higher rate of neurodevelopmental disability at 2 years, according to a study published in the Jan. 11 issue of the New England Journal of Medicine.
Some Patients Would Choose Antibiotics for Appendicitis
WEDNESDAY, Jan. 10, 2018 (HealthDay News) — Although most patients would choose surgical intervention for treatment of acute uncomplicated appendicitis, some would opt for antibiotics alone, according to a study published online Jan. 10 in JAMA Surgery.
School-Based Telemedicine Asthma Management Is Effective
WEDNESDAY, Jan. 10, 2018 (HealthDay News) — A School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) program can improve symptoms for children with persistent asthma, according to a study published online Jan. 8 in JAMA Pediatrics.
Vitamin D3 Improves Arterial Stiffness in Dose-Response Way
WEDNESDAY, Jan. 10, 2018 (HealthDay News) — For overweight African-Americans with vitamin D deficiency, arterial stiffness is improved by vitamin D3 supplementation in a dose-response manner, according to a study published online Dec. 7 in PLOS ONE.
Barriers to Initial Chemo, Radiation for Small-Cell Lung CA
WEDNESDAY, Jan. 10, 2018 (HealthDay News) — A considerable proportion of patients with small-cell lung cancer (SCLC) do not receive chemotherapy or radiation therapy, according to a study published online Jan. 4 in JAMA Oncology.
Idalopirdine May Not Improve Cognition in Mild Alzheimer’s
TUESDAY, Jan. 9, 2018 (HealthDay News) — The use of idalopirdine does not improve cognition versus placebo over 24 weeks of treatment for patients with mild-to-moderate Alzheimer’s disease (AD), according to research published in the Jan. 9 issue of the Journal of the American Medical Association.
Screening, Therapy Effect Varies by Breast CA Molecular Subtype
TUESDAY, Jan. 9, 2018 (HealthDay News) — The contributions of screening and treatment to decreases in breast cancer mortality vary by molecular subtype, according to a study published in the Jan. 9 issue of the Journal of the American Medical Association.
Week’s Worth of HIV Meds in a Single-Dose Capsule Feasible
TUESDAY, Jan. 9, 2018 (HealthDay News) — A novel oral dosage form enables sustained release of antiretrovirals, allowing delivery for up to one week after a single administration, according to a study published online Jan. 9 in Nature Communications.
Rituximab Tops Other Disease-Modifying Tx Options in MS
TUESDAY, Jan. 9, 2018 (HealthDay News) — Rituximab has better efficacy and lower discontinuation rates than other disease-modifying treatment (DMT) choices for newly diagnosed relapsing-remitting multiple sclerosis (RRMS), according to a study published online Jan. 8 in JAMA Neurology.
Intense End-of-Life Care Found to Be Less Likely for VA Patients
TUESDAY, Jan. 9, 2018 (HealthDay News) — Higher-intensity end-of-life care may be driven by financial incentives present in fee-for-service Medicare but not in the Veteran Affairs (VA) integrated system, according to a report published in the January issue of Health Affairs.
Repeated Flu Vaccinations Help Prevent Severe Infection
MONDAY, Jan. 8, 2018 (HealthDay News) — Vaccination for influenza for multiple seasons is twice as effective in preventing severe influenza — compared with non-severe influenza — in older patients admitted to hospital, according to a study published in the Jan. 8 issue of CMAJ, the journal of the Canadian Medical Association.
Maternal Folic Acid, Multivitamin Use May Cut ASD Risk in Offspring
MONDAY, Jan. 8, 2018 (HealthDay News) — The risk of autism spectrum disorder (ASD) is reduced in offspring with maternal exposure to folic acid and multivitamin supplementation before and during pregnancy, according to a study published online Jan. 3 in JAMA Psychiatry.
Pharmacies Can Up Access to Direct-Acting Antivirals for Hep C
MONDAY, Jan. 8, 2018 (HealthDay News) — Provider collaboration with local specialty pharmacies (LSPs) is associated with reduced delays in therapy and lower rates of direct-acting antiviral (DAA) denial for patients with hepatitis C, according to a study published in the January/February issue of the Journal of the American Pharmacists Association.
Socioeconomic Factors Associated With Opioid Prescriptions
FRIDAY, Jan. 5, 2018 (HealthDay News) — Among disabled Medicare beneficiaries, county-level socioeconomic factors are associated with opioid prescriptions, with more prescriptions seen with lower socioeconomic indicators, according to a study published in the January issue of Medical Care.
Hydrochlorothiazide May Up Basal, Squamous Cell Cancer Risk
FRIDAY, Jan. 5, 2018 (HealthDay News) — Hydrochlorothiazide use is associated with an increased risk of non-melanoma skin cancer (NMSC), with evidence of a dose-response relationship, according to a study published online Dec. 3 in the Journal of the American Academy of Dermatology.
Fluorouracil Tied to Reduced Surgery for Squamous Cell CA
FRIDAY, Jan. 5, 2018 (HealthDay News) — Fluorouracil application can reduce the risk of surgery for squamous cell carcinoma for one year among patients with a history of keratinocyte carcinomas, according to a study published online Jan. 3 in JAMA Dermatology.
Immune-Related Adverse Events Up With Checkpoint Inhibitors
THURSDAY, Jan. 4, 2018 (HealthDay News) — Although patients with pre-existing autoimmune disease who receive checkpoint inhibitors (CPIs) are at risk for exacerbation of their disease, immune-related adverse events (irAEs), or both, events can often be managed without discontinuing CPIs, according to a review published online Jan. 2 in the Annals of Internal Medicine.
CVD Risk Up With β2-Agonist, Antimuscarinic Antagonist Start
THURSDAY, Jan. 4, 2018 (HealthDay News) — For patients with chronic obstructive pulmonary disease (COPD), new initiation of inhaled long-acting β2-agonists (LABAs) and long-acting antimuscarinic antagonists (LAMAs) is associated with increased risk of cardiovascular disease (CVD), according to a study published online Jan. 2 in JAMA Internal Medicine.
Esketamine Safe, Effective for Treatment-Resistant Depression
THURSDAY, Jan. 4, 2018 (HealthDay News) — Esketamine seems to be efficacious and safe for patients with treatment-resistant depression (TRD), according to a study published online Dec. 27 in JAMA Psychiatry.
Stem-Cell Transplantation Beneficial for Scleroderma
WEDNESDAY, Jan. 3, 2018 (HealthDay News) — For patients with scleroderma, myeloablative CD34+ selected autologous hematopoietic stem-cell transplantation is associated with lasting benefits, according to a study published in the Jan. 4 issue of the New England Journal of Medicine.
Improvement Needed in Ob-Gyn Opioid Prescribing Practices
WEDNESDAY, Jan. 3, 2018 (HealthDay News) — Improvement in obstetrician-gynecologists’ knowledge and prescribing practices regarding opioids is needed, according to a study published online Dec. 4 in Obstetrics & Gynecology.
Dasiglucagon Well Tolerated for Severe Hypoglycemia
WEDNESDAY, Jan. 3, 2018 (HealthDay News) — Dasiglucagon is well tolerated and is associated with an early pharmacodynamic response similar to that of GlucaGen for severe hypoglycemia, according to a study published online Dec. 22 in Diabetes Care.
Few Immuno-Oncology Agents Reach ASCO Efficacy Thresholds
WEDNESDAY, Jan. 3, 2018 (HealthDay News) — Few modern, U.S. Food and Drug Administration-approved immuno-oncology agents have durable survival and response rates that are deemed significant by the American Society of Clinical Oncology (ASCO) value framework, according to a study published online Dec. 28 in JAMA Oncology.
Predictors of Infliximab Response in Ulcerative Colitis Identified
WEDNESDAY, Jan. 3, 2018 (HealthDay News) — For patients with acute severe ulcerative colitis (ASUC), the baseline Mayo Endoscopic Score and the C-reactive protein (CRP)/albumin ratio predict treatment response to infliximab, according to research published online Dec. 21 in the Journal of Gastroenterology and Hepatology.
In Utero Exposure to Topiramate Linked to Risk of Oral Clefts
TUESDAY, Jan. 2, 2018 (HealthDay News) — Infants born to women exposed to topiramate, especially women with epilepsy taking higher doses, have an increased risk of oral clefts at birth, according to a study published online Dec. 27 in Neurology.
Smart Extendin-4 Delivery Device Promising for Type 2 Diabetes
TUESDAY, Jan. 2, 2018 (HealthDay News) — A smart extendin-4 (Ex4) delivery device is a promising therapeutic option for type 2 diabetes that can provide safe, long-term, and on-demand Ex4 therapy, according to a study published online Nov. 24 in Nature Communications.
Broader Statin Use Improves Atherosclerotic CVD Prevention
TUESDAY, Jan. 2, 2018 (HealthDay News) — Guidelines that recommend statins for more people for primary prevention of atherosclerosis are likely to prevent more atherosclerotic cardiovascular disease (ASCVD) events than guidelines that recommend fewer people take statins, according to a study published online Jan. 1 in the Annals of Internal Medicine.
Increase Seen in Gabapentinoid Use From 2002 to 2015
TUESDAY, Jan. 2, 2018 (HealthDay News) — From 2002 to 2015 there was a substantial increase in gabapentinoid use, according to a research letter published online Jan. 2 in JAMA Internal Medicine.
Pharmaceutical Aids Not Found to Be Helpful for Smoking Cessation
TUESDAY, Jan. 2, 2018 (HealthDay News) — Pharmaceutical aids are not effective for increasing long-term smoking cessation, according to a study published online Dec. 21 in the Journal of the National Cancer Institute.
Folic Acid Lessens Autism Risk for Fetal Anti-Epileptic Exposure
TUESDAY, Jan. 2, 2018 (HealthDay News) — For children exposed to antiepileptic drugs (AEDs) in utero, the risk of autistic traits may be mitigated by use of periconceptional folic acid supplementation, according to a study published online Dec. 26 in JAMA Neurology.
Same-Day, Low-Dose Bowel Prep Feasible for Colonoscopy
TUESDAY, Jan. 2, 2018 (HealthDay News) — A same-day, low-dose, 1-liter polyethylene glycol-based (1L-PEG) bowel preparation can achieve similar bowel cleansing to split-dose 4L-PEG bowel preparation in select high-risk patients before colonoscopy, according to a study published online Dec. 21 in the Journal of Digestive Diseases.
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